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genome PhD Projects, Programs & Scholarships

We have 238 genome PhD Projects, Programs & Scholarships

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  MRC Precision Medicine DTP: 3D modelling of changes in genome architecture in development and disease
  Research Group: Institute of Cell Biology
  Prof E Schirmer, Dr D Marenduzzo
Application Deadline: 8 April 2019
Background. Defects in spatial genome organisation have recently been linked to human disease and the National Institutes of Health, USA director speculated that most as yet unidentified disease alleles will occur in non-coding genome regions.
  Characterising mechanisms that control Marek’s Disease Virus genome release from telomeres during reactivation from latency
  Dr N J Royle, Dr R Badge
Application Deadline: 5 May 2019
Infection by Marek’s Disease Virus (MDV) is followed by latency, T-cell lymphomas and reactivation. It has significant deleterious effects on chicken health and welfare, with an annual estimated loss close to $2 billion to the global poultry meat and egg production industries.
  Using CRISPR genome editing to determine the effects of obesity and hypertension associated polymorphisms
  Dr A MacKenzie, Prof M Delibegovic
Application Deadline: 29 March 2019
Introduction. There is now little doubt that morbid conditions such as obesity, cardiovascular disease and diabetes are mechanistically linked.
  Clinical Genetics: Building the skull – normal and abnormal development
  Prof A Wilkie, Dr S Twigg
Application Deadline: 26 July 2019
Working closely with the craniofacial teams based in Oxford and other UK units, we specialise in the application of whole exome and genome sequencing to children born with a serious malformation of the skull termed craniosynostosis.
  Genomics, gene regulation and disease: how mammalian genes are regulated and how their deregulation is linked with human disease
  Assoc Prof J Hughes, Prof T Milne
Application Deadline: 26 July 2019
The Hughes group is interested in how mammalian genes are regulated and how their deregulation is linked with human disease. The ~22 thousand genes in the mammalian genome are present in the DNA of every cell but are used in complex patterns in different cell types and organs.
  Transcription regulation in the context of genome stability
  Dr M Saponaro
Applications accepted all year round
The DNA in our cells is a substrate for both RNA Pol II (RNAPII) transcription and DNA replication. Consequently, only one of the two processes can use the DNA as a template at any given time.
  Chromatin and maintenance of genome stability
  Dr A Chambers
Applications accepted all year round
Within eukaryotes, DNA is packaged into chromatin. The basic unit of chromatin is the nucleosome, formed by the wrapping of ~147 bp of DNA around an octamer of histones proteins.
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round
The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
  Medical Research Council (MRC) Cancer and Genome Integrity PhD Programme 2019
Defects in DNA replication or DNA repair can lead to mutations and other genomic alterations that give rise to cancers, and consequently tumours tend to have a high degree of genome instability.
  Studying chloroplast biogenesis in the basal land plant Marchantia polymorpha: Using CRISPR/Cas9 genome editing and forward genetics to assess functional conservation and seek novel components
  Prof P Jarvis, Prof L Dolan
Applications accepted all year round
Chloroplasts are responsible for photosynthesis, and are the organelles that define plants [1]. They evolved as a result of an endosymbiotic relationship between a cyanobacterium and an algal progenitor, in a process that began over a billion years ago.
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