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genome PhD Projects, Programmes & Scholarships

We have 175 genome PhD Projects, Programmes & Scholarships

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We have 175 genome PhD Projects, Programmes & Scholarships

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Genome Diversification in Cancer and Adaptive Immunity

Genomic instability (GI) is a hallmark of cancer that plays a central role in its initiation and development. GI can arise as a result of germline and somatic mutations that compromise a cell’s ability to accurately sense, signal or repair DNA damage. Read more

Genome Diversification in Cancer and Adaptive Immunity

Genomic instability (GI) is a hallmark of cancer that plays a central role in its initiation and development. GI can arise as a result of germline and somatic mutations that compromise a cell’s ability to accurately sense, signal or repair DNA damage. Read more

Revealing epigenetic signaling mechanisms in genome regulation and cancer.

We are looking for highly motivated PhD students to join our efforts to reveal epigenetic mechanisms that regulate the function of eukaryotic genomes in health and disease. Read more

The non-coding genome in cardiovascular disease

Cardiovascular disease is the leading cause of death worldwide. Inherited DNA sequence variants play a role in conferring risk for disease, yet we can only predict the harmful effects of mutations in the protein-encoding portion of a gene. Read more

Interplay of chromatin and maintenance of genome stability

Genome instability is a known driver of tumourigenesis and hallmark of cancer. Efficient eukaryotic DNA repair requires changes to chromatin to allow signalling and access of repair proteins to sites of damage. Read more

Building the skull - normal and abnormal development

Using a combination of patient samples and mouse models, we study the causes and developmental origins of skull malformation. The work ranges from screening human DNA for new mutations, to use of genome editing and single cell transcriptomics to model the developmental causes of these malformations in mice. Read more

Universal genome editing strategies for ataxia telangiectasia

Ataxia telangiectasia (A-T) is a severe autosomal recessive genetic disease caused by mutations in the ATM gene, which lead to cerebellar degeneration, cancer susceptibility and immunodeficiency. Read more

3D genome folding and its role in DNA-based processes

The organization of genomic DNA into chromatin fibres and nucleosomes and their regulation by histone modifications is well understood, as is the relevance of these mechanisms for gene regulation. Read more

PhD position in genome stability and Cancer –Sept 2022

All organisms can suffer DNA double-strand breaks (DSBs), during meiosis, during DNA replication as elongating forks stall or collapse, or as a consequence of treatment with DNA damaging agents such as ionizing radiation. Read more
Last chance to apply

Transcription: molecular mechanisms & dynamics

This project is available through the MIBTP programme. The successful applicant will join the MIBTP cohort and will take part in all of the training offered by the programme. For further details. Read more

Genome mining of novel antimicrobial and antiviral natural products from new bacterial strains

Antimicrobial resistance (AMR) is rising to dangerously high levels in all parts of the world. In Europe alone, drug-resistant bacteria are estimated to cause 25,000 deaths annually and cost more than US$1.5 billion every year in healthcare expenses and productivity losses. Read more

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