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We have 149 genome PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
genome PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 149 genome PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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Molecular mechanism of P. faciparum apicoplast replication and genome organisation
We invite applications for two PhD research projects to study organellar protein-DNA interactions in Plasmodium, the pathogen responsible for causing malaria. Read more
MScR: Interplay of chromatin remodelling and maintenance of genome stability
Genome instability is a known driver of tumourigenesis and hallmark of cancer. Efficient eukaryotic DNA repair requires changes to chromatin to allow signalling and access of repair proteins to sites of damage. Read more
Alternative genomic mechanisms of antibiotic resistance in Mycobacterium tuberculosis: implications for drug development to target AMR and emerging pathogens
Applications are invited for the following PhD project commencing in October 2023. The project is a collaboration between the UK Health Security Agency (UKHSA) (subject to contract) and the University of Bath, providing the student with the experience of working at both organisations. Read more
Investigating how large-scale genome instability in fungi contributes to the host-pathogen interactions.
Fungal infections affect billions of people, including >1.5 million global deaths each year. Our failure to achieve cure against fungal infections results from the high levels of tolerance and resistance to antifungal drugs in clinical fungal isolates. Read more
SynBac: Synthetic Baculovirus Genomes for Next-generation Drug Discovery and Gene Therapy
Baculovirus is a highly efficient delivery system for recombinant genes into eukaryotic cells, with great impact on the production of eukaryotic proteins, including high-value drug targets for pharmaceutical development. Read more
Examining the legal, ethical and social implications of whole genome sequencing at birth
Developments in genomic testing mean that it is now possible to conduct whole genome sequencing of newborn infants. Read more
Using genome engineering and bioinformatics to understand heterochromatin and centromere function in Schizosaccharomyces pombe and in cancer cells
Centromeres are the DNA sequences on eukaryotic chromosomes that mediate accurate chromosome segregation at both mitotic and meiotic cell divisions. Read more
Single-cell measurements of mutation dynamics across bacterial genome
Genetic mutations are the raw material of evolution, driving evolutionary innovations. Mutation rate is thus a key factor determining how organisms adapt to new environments and whether they survive a severe environmental challenge, such as the antibiotic treatment. Read more
Genome engineering and centromere diversity
Centromeres are the DNA sequences that are responsible for accurate segregation of eukaryotic chromosomes at cell division. Although centromeres mediate a conserved function they are remarkably diverse in evolution. Read more
MScR - In vivo characterisation of novel risk genes for Alzheimers disease identified by Genome Wide Association Studies
Genome Wide Association Studies (GWAS) for Alzheimer’s disease (AD) have identified a number of genes that are significantly associated with the disease (van der Kant et al., 2019). Read more
Combining genome-scale metabolic models and multi-omics data for a system level understanding of bacteria
Understanding microbial metabolism is essential for the exploitation of bacteria in a number of different biotechnological applications, the members of the Streptomyces genus being a particularly biotechnologically interesting example (Del Carratore et al., 2022). Read more
MSc by Research: Using genome editing to study the mechanisms of immune cell proliferation and differentiation
T lymphocytes mediate long-term adaptive immunity to viruses and tumour cells. T lymphocytes recognize foreign antigens via specific interactions with the T cell receptor (TCR) that is expressed on the cell surface. Read more
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MSc By Research: Exploring the genetics and epigenetics of anxiety
Background. Anxiety disorders are becoming increasingly common, with the incidence of chronic anxiety increasing by 50% in the past 20 years, particularly among young adults. Read more
Tissue-specific roles of human endogenous retroviruses in urothelial carcinoma
Human endogenous retroviruses (HERVs) are the remnants of retroviral infections in our evolutionary past that contribute 8% of our genome. Read more
Clinical Gastroenterology: Investigation of Fidaxomicin Resistance Mechanisms in Clostridium difficile
Clostridium difficile is a leading pathogen in healthcare-associated diarrheal infections. C. difficile has a plastic genome with multiple mobile genetic elements and recognized capacity to acquire genes involved in resistance and virulence. Read more