We have 99 genomic PhD Projects, Programmes & Scholarships

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genomic PhD Projects, Programmes & Scholarships

We have 99 genomic PhD Projects, Programmes & Scholarships

Deep Tissue Phenotyping and Explainable AI

Background. As life sciences becomes increasingly data-centric, AI techniques including deep learning neural networks and classical machine learning algorithms are increasingly being used to characterise, classify, and make predictions from biological datasets. Read more

Li Fraumeni Syndrome, p53 and cancer

Li Fraumeni Syndrome (LFS) is a rare genetic condition caused by germline TP53 mutations, either inherited or occurring at conception, which results in a strong predisposition to cancer (>90% and 70% lifetime risk for women and men, respectively). Read more

Epigenetic regulation of bivalent genes in development and cancer

Our groups are interested in identifying epigenetic mechanisms driving cancer progression. Although it is well known that cancer cells harbor many DNA mutations, they also have significant alterations of their epigenome. Read more

Decoding the epitranscriptome in cancer

Cellular RNA is decorated with diverse chemical modifications, which participate in all aspects of RNA biology. The multitude of modifications in RNA adds a new layer to gene regulation, leading to the emerging field of epitranscriptomics. Read more

Novel insights into urban pollution of freshwater ecosystems derived from integrative ecotoxicology, genetics and hydrologic modelling

Scientific challenge: Freshwater systems are one of the most threatened habitat types on Earth. Within this context, increases in urbanisation and the effects of anthropogenic climate change have led to a decrease in water quality and availability worldwide. Read more

Chemical evolution of artificial oligonucleotide catalysts for ultra-specific RNA detection and knockdown

Beyond information storage, single-stranded nucleic acids can adopt complex 3D structures with biochemical activities, e.g. antisense oligonucleotides (ASOs), chemical antibodies (aptamers) and catalysts (ribozymes, DNAzymes). Read more

Disentangling the pathways and molecular basis of inverse associations between Alzheimer's disease and cancer

Epidemiological studies and systematic reviews report unexplained inverse associations between risk of developing Alzheimer's disease (AD) and risk of cancer (Shafi, (2016); Zablocka et al (2021)). Read more

Diagnostics for FMF patients and carrier survival in pandemics

Background. Familial Mediterranean Fever (FMF) is a rare inherited genetic disease where patients acquire a mutation on the pyrin gene leading to excessive inflammasome activation and excessive inflammation. Read more

Endosymbionts as an overlooked threat for insect reintroductions

Background. Species reintroduction - or augmentation - into restored habitat will be increasingly used to combat biodiversity loss in a rapidly changing world, and used for a wider range of taxa, including invertebrates. Read more

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