Chronic inflammatory diseases (CIDs) are a common group of highly disabling immune conditions leading to persistent inflammation and tissue-specific manifestations, such as ulcerative colitis and arthritis.
The phosphoinositide 3-kinase (PI3K) pathway is a master regulator of numerous cellular phenotypes associated with cancer including cell survival, proliferation, growth, altered metabolism and malignant transformation.
Stress is associated with significant morbidity including depression and anxiety. Activation of the hypothalamic-pituitary-adrenal (HPA) axis leads to synthesis of cortisol, which is a key mediator of the pathology of chronic stress.
Giant cell arteritis (GCA) is the commonest primary systemic vasculitis, occurring exclusively after 50yrs. Irreversible ischaemic complications, including blindness, occur in 19% of UK patients, despite prompt treatment.
Employing a range of approaches to address the physiological importance of the circadian:nuclear receptor system, ranging from population genetics, experimental medicine studies, CRISPR engineered mice, and cell biology.