The involvement of iron in the development of Parkinson’s Disease is now well recognised. Iron seems to be accumulating in the neurons of sufferers and is involved in the formation of reactive oxygen species that cause oxidative damage to neurons, resulting in their death. Read more
The COVID-19 pandemic has seen unprecedented development and employment of new vaccine technologies that can be produced and administered quickly. Read more
Our laboratory specializes in the use of optimization-based methods to model, analyze and control uncertain, nonlinear and fluidic (PDE) systems. Read more
It is estimated that there are close to 50 million people living with dementia worldwide, and this number is estimated to double every 20 years. Read more
Almost all physiological processes are regulated through the activation of G protein-coupled receptors (GPCRs). It has become widely accepted that most GPCRs possess binding sites spatially distinct from their natural ligand binding site (orthosteric site), termed as allosteric sites. Read more
Malaria is a life-threatening infectious disease caused by the plasmodium protozoan parasite passed through the bites of infected female Anopheles mosquitoes. Read more
The attachment of Pseudomonas aeruginosa (PA) to the airway mucus in the lungs of people with cystic fibrosis (CF) represents an important step in airway colonization and the subsequent development of lung infection. Read more
E. faecium is an important human pathogen which exhibits resistance to a range of antibiotics, and is implicated in a wide variety of device associated infections. Read more
Non-adherence to treatment costs the NHS more than £500M each year. Adherence is especially important when treating patients with chronic conditions that require lifetime pharmacological treatment, such as schizophrenia, Parkinson’s disease, HIV and Alzheimer’s disease. Read more
Obesity has reached epidemic proportions in the UK. Over 60% of UK adults are either obese or overweight, and one in three has liver steatosis, an accumulation of fat in the liver considered to be an early stage of non-alcoholic fatty liver disease (NAFLD). Read more
The overall aim of this project is to understand how benzodiazepines and opioids interact to increase the likelihood of fatal overdose (both from a neuro-biological and drug-user perspective) so that we can help design new harm reduction interventions that could reduce the number of overdoses in the population. Read more
How do animals interact in groups? What benefits and costs can this bring? What are the ecological effects of social living? How do differences between… Read more
Primary open-angle glaucoma is a major source of disability and blindness. Genetic studies have been hugely successful in improving our understanding of this disease, but the mechanisms through which, in interaction with non-genetic factors, they can lead to glaucoma is not well understood. Read more
The group has published on the discovery of heterocyclic quinone anti-cancer agents with specificity towards hypoxic cells associated with solid tumours… Read more
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