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histone PhD Projects, Programs & Scholarships

We have 21 histone PhD Projects, Programs & Scholarships

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  A structural basis for the cross-talk between histones and RNA Polymerase II
  Prof R Stefl, Dr K Kubicek, Prof S Vanacova
Application Deadline: 3 February 2019
Chromatin is a highly flexible architecture in which spatially and temporally coordinated changes between structurally condensed states (transcriptionally repressive), and structurally accessible states (transcriptionally active) regulate gene expression.
  Transcriptional Control of Stem Cell Differentiation
  Research Group: Gene Expression
  Dr S Cowley
Applications accepted all year round
The ability to regulate the transcriptional activity of protein coding genes is one of the most fundamental processes of life. The transcriptional potential of a gene is directly related to its chromatin context, which in turn, is influenced by the covalent modification of its core histone components.
  Development of treatment for Osteoarthritis by blocking metalloproteinases
  Prof G Bou-Gharios
Applications accepted all year round
MMP13 (collagenase 3) plays a vital role in the pathogenesis of osteoarthritis (OA) because MMP13 preferentially cleaves type II collagen, the main component of cartilage, and both MMP13 levels and enzymatic activity are enhanced in OA.
  Chromatin and maintenance of genome stability
  Dr A Chambers
Applications accepted all year round
Within eukaryotes, DNA is packaged into chromatin. The basic unit of chromatin is the nucleosome, formed by the wrapping of ~147 bp of DNA around an octamer of histones proteins.
  Molecular analysis of neutrophil extracellular traps (NETs) in rheumatoid arthritis
  Dr HL Wright, Prof RJ Moots
Applications accepted all year round
Neutrophil extracellular traps (NETs) kill pathogens via the release of chromatin and anti-microbial granule enzymes in an extracellular mesh or “net”.
  Epigenetic regulation in heart failure and cardiac sudden death
  Dr X Wang, Dr V Liu
Applications accepted all year round
A large proportion of heart failure patients die from cardiac sudden death (SCD), a direct result of lethal ventricular arrhythmias, which is the principal cause of mortality from heart disease worldwide and remains a major unresolved public health problem.
  Centromere inheritance in S. pombe and beyond
  Dr L Subramanian
Applications accepted all year round
Accurate chromosome segregation relies on the stable inheritance of functional centromeres through generations. A key determinant of centromere function is the histone H3 variant CENP-A (Centromere Protein A), that epigenetically marks and specifies active centromeres.
  Dissecting the role of the epigenetic reader TRIM33 in Multiple Myeloma
  Research Group: Centre for Cancer Research and Cell Biology
  Dr L Crawford, Prof K Mills
Application Deadline: 20 January 2019
Multiple Myeloma (MM) is a haematological neoplasm characterised by the clonal proliferation of malignant plasma cells in the bone marrow.
  RNA methylation/modification as a biomarker or therapeutic target in myeloid malignancies
  Research Group: Centre for Cancer Research and Cell Biology
  Prof K Mills, Dr F Furlong
Application Deadline: 20 January 2019
Myeloid malignancies such as Myeloproliferative neoplasms (MPN), Myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML) represent a spectrum of diseases affecting the haematopoietic cell development and differentiation.
  PhD Student (f/m/d) in the field of Chromosome Biology
  Ms H Böhme
Application Deadline: 16 February 2019
The research group Chromosome structure and function is interested in the process of chromosome segregation.
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