histone PhD Projects, Programs & Scholarships

We have 21 histone PhD Projects, Programs & Scholarships

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Showing 1 to 10 of 21 PhDs

A structural basis for the cross-talk between histones and RNA Polymerase II

Masaryk University
CEITEC

Prof R Stefl, Dr K Kubicek, Prof S Vanacova

Application Deadline: 3 February 2019

Chromatin is a highly flexible architecture in which spatially and temporally coordinated changes between structurally condensed states (transcriptionally repressive), and structurally accessible states (transcriptionally active) regulate gene expression.

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PhD Research Project Type/Funding

Transcriptional Control of Stem Cell Differentiation

University of Leicester
Molecular and Cell Biology

Research Group: Gene Expression

Dr S Cowley

Applications accepted all year round

The ability to regulate the transcriptional activity of protein coding genes is one of the most fundamental processes of life. The transcriptional potential of a gene is directly related to its chromatin context, which in turn, is influenced by the covalent modification of its core histone components.

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PhD Research Project Type/Funding

Development of treatment for Osteoarthritis by blocking metalloproteinases

University of Liverpool
Institute of Ageing and Chronic Disease

Prof G Bou-Gharios

Applications accepted all year round

MMP13 (collagenase 3) plays a vital role in the pathogenesis of osteoarthritis (OA) because MMP13 preferentially cleaves type II collagen, the main component of cartilage, and both MMP13 levels and enzymatic activity are enhanced in OA.

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PhD Research Project Type/Funding

Chromatin and maintenance of genome stability

University of Bristol
School of Biochemistry

Dr A Chambers

Applications accepted all year round

Within eukaryotes, DNA is packaged into chromatin. The basic unit of chromatin is the nucleosome, formed by the wrapping of ~147 bp of DNA around an octamer of histones proteins.

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PhD Research Project Type/Funding

Molecular analysis of neutrophil extracellular traps (NETs) in rheumatoid arthritis

University of Liverpool
Institute of Ageing and Chronic Disease

Dr HL Wright, Prof RJ Moots

Applications accepted all year round

Neutrophil extracellular traps (NETs) kill pathogens via the release of chromatin and anti-microbial granule enzymes in an extracellular mesh or “net”.

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PhD Research Project Type/Funding

Epigenetic regulation in heart failure and cardiac sudden death

University of Manchester
Faculty of Biology, Medicine and Health

Dr X Wang, Dr V Liu

Applications accepted all year round

A large proportion of heart failure patients die from cardiac sudden death (SCD), a direct result of lethal ventricular arrhythmias, which is the principal cause of mortality from heart disease worldwide and remains a major unresolved public health problem.

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PhD Research Project Type/Funding

Centromere inheritance in S. pombe and beyond

Queen Mary University of London
School of Biological & Chemical Sciences

Dr L Subramanian

Applications accepted all year round

Accurate chromosome segregation relies on the stable inheritance of functional centromeres through generations. A key determinant of centromere function is the histone H3 variant CENP-A (Centromere Protein A), that epigenetically marks and specifies active centromeres.

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PhD Research Project Type/Funding

Dissecting the role of the epigenetic reader TRIM33 in Multiple Myeloma

Queen’s University Belfast
School of Medicine, Dentistry & Biomedical Sciences

Research Group: Centre for Cancer Research and Cell Biology

Dr L Crawford, Prof K Mills

Application Deadline: 20 January 2019

Multiple Myeloma (MM) is a haematological neoplasm characterised by the clonal proliferation of malignant plasma cells in the bone marrow.

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PhD Research Project Type/Funding

RNA methylation/modification as a biomarker or therapeutic target in myeloid malignancies

Queen’s University Belfast
School of Medicine, Dentistry & Biomedical Sciences

Research Group: Centre for Cancer Research and Cell Biology

Prof K Mills, Dr F Furlong

Application Deadline: 20 January 2019

Myeloid malignancies such as Myeloproliferative neoplasms (MPN), Myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML) represent a spectrum of diseases affecting the haematopoietic cell development and differentiation.

Details

PhD Research Project Type/Funding

PhD Student (f/m/d) in the field of Chromosome Biology

The Leibniz Institute of Plant Genetics and Crop Plant Research (IPK)
Leibniz Institute of Plant Genetics and Crop Plant Research (IPK)

Ms H Böhme

Application Deadline: 16 February 2019

The research group Chromosome structure and function is interested in the process of chromosome segregation.

Details