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histone PhD Projects, Programmes & Scholarships
We have 11 histone PhD Projects, Programmes & Scholarships
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Diversifying the histone code: defining the role of non-canonical phosphorylation in chromatin structure
This opportunity will remain open until the position has been filled. Post-translational modifications (PTMs) of histones are known to direct chromatin structure and thus gene transcription. Read more
Epitranscriptomic mechanisms in the maternal to zygotic transition of vertebrate embryos
Research Group:
BBSRC MIBTP
Most mRNAs contain modified nucleotides in mRNA, but we know very little about their function (Haussmann et al, 2016, Dezi et al, 2016, Roignant and Soller, 2017). Read more
Understanding gene regulation by HDAC1 complexes in development and cancer
Packaging DNA into nucleosomes helps protect the long fragile genomes of eukaryotic species. However, in doing so it becomes an ever-present physical barrier to the machinery required for its replication, repair and transcription. Read more
Evaluation of combination therapies targeting DNA damage repair signalling pathways in acute myeloid leukaemia
Acute myeloid leukaemia (AML) is an aggressive cancer affecting mostly adult and elderly patients. It has a very poor 5-year survival of <20% in the UK. Read more
Gene regulation using a CRISPR/Cas9-based histone variant deposition
Pseudogenes are functionless remnants of DNA that are copied from parental genes during evolution. EP400 N-terminal-Like (EP400NL) gene was thought to be a pseudogene, located next to the parental EP400 gene in the chromosome. Read more
3D genome folding and its role in DNA-based processes
The organization of genomic DNA into chromatin fibres and nucleosomes and their regulation by histone modifications is well understood, as is the relevance of these mechanisms for gene regulation. Read more
Deciphering a novel anti-ageing epigenetic programme
Over two decades of intense research in the field of epigenetics have produced compelling evidence that chromatin modifications are crucial for processes such as DNA repair, transcription, splicing, mitosis, meiosis, and in the preservation of the epigenetic memory of cells. Read more
The interplay between genetics and brain development in schizophrenia
Supervisors. Dr Michael Ashby, University of Bristol, Prof Anthony Isles, University of Cardiff, Dr Emma Cahill, University of Bristol, Prof Jonathan Mill, University of Exeter. Read more
Function of R-loops in health and disease
R-loops are unusual RNA/DNA structures, formed in all living organisms where they play crucial roles in regulating gene expression, DNA and histone modifications, generation of antibody diversity, DNA replication and genome stability. Read more
Targeting protein acetylation to reduce microglia activation in neurodegenerative disorders
Recently, inhibitors of histone deacetylase enzymes (HDACs) have been identified as having potential therapeutic value for a range of neuronal disorders including Alzheimer’s disease, dementia and stroke [1, 2]. Read more
Revealing epigenetic signaling mechanisms in genome regulation and cancer.
We are looking for highly motivated PhD students to join our efforts to reveal epigenetic mechanisms that regulate the function of eukaryotic genomes in health and disease. Read more
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