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histone PhD Projects, Programmes & Scholarships

We have 11 histone PhD Projects, Programmes & Scholarships

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We have 11 histone PhD Projects, Programmes & Scholarships

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Understanding gene regulation by HDAC1 complexes in development and cancer

Packaging DNA into nucleosomes helps protect the long fragile genomes of eukaryotic species. However, in doing so it becomes an ever-present physical barrier to the machinery required for its replication, repair and transcription. Read more

Gene regulation using a CRISPR/Cas9-based histone variant deposition

Pseudogenes are functionless remnants of DNA that are copied from parental genes during evolution. EP400 N-terminal-Like (EP400NL) gene was thought to be a pseudogene, located next to the parental EP400 gene in the chromosome. Read more

3D genome folding and its role in DNA-based processes

The organization of genomic DNA into chromatin fibres and nucleosomes and their regulation by histone modifications is well understood, as is the relevance of these mechanisms for gene regulation. Read more

Deciphering a novel anti-ageing epigenetic programme

Over two decades of intense research in the field of epigenetics have produced compelling evidence that chromatin modifications are crucial for processes such as DNA repair, transcription, splicing, mitosis, meiosis, and in the preservation of the epigenetic memory of cells. Read more

The interplay between genetics and brain development in schizophrenia

Supervisors. Dr Michael Ashby, University of Bristol, Prof Anthony Isles, University of Cardiff, Dr Emma Cahill, University of Bristol, Prof Jonathan Mill, University of Exeter. Read more

Function of R-loops in health and disease

R-loops are unusual RNA/DNA structures, formed in all living organisms where they play crucial roles in regulating gene expression, DNA and histone modifications, generation of antibody diversity, DNA replication and genome stability. Read more

Targeting protein acetylation to reduce microglia activation in neurodegenerative disorders

Recently, inhibitors of histone deacetylase enzymes (HDACs) have been identified as having potential therapeutic value for a range of neuronal disorders including Alzheimer’s disease, dementia and stroke [1, 2]. Read more

Revealing epigenetic signaling mechanisms in genome regulation and cancer.

We are looking for highly motivated PhD students to join our efforts to reveal epigenetic mechanisms that regulate the function of eukaryotic genomes in health and disease. Read more
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