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histone PhD Projects, Programs & Scholarships

We have 21 histone PhD Projects, Programs & Scholarships

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  Epitranscriptomic mechanisms in the maternal to zygotic transition of vertebrate embryos
  Dr M Soller, Prof F Mueller
Applications accepted all year round
Most mRNAs contain modified nucleotides in mRNA, but we know very little about their function (Haussmann et al, 2016, Dezi et al, 2016, Roignant and Soller, 2017).
  The molecular basis of human tendon pathologies: Studying both epigenetic and global gene expression profiles
  Prof H Maddock
Application Deadline: 31 May 2019
Soft tissue disorders represent the third most common musculoskeletal condition in the UK (18 cases per 1000). These primarily affect tendons.
  Transcriptional Control of Stem Cell Differentiation
  Research Group: Gene Expression
  Dr S Cowley
Applications accepted all year round
The ability to regulate the transcriptional activity of protein coding genes is one of the most fundamental processes of life. The transcriptional potential of a gene is directly related to its chromatin context, which in turn, is influenced by the covalent modification of its core histone components.
  Development of treatment for Osteoarthritis by blocking metalloproteinases
  Prof G Bou-Gharios
Applications accepted all year round
MMP13 (collagenase 3) plays a vital role in the pathogenesis of osteoarthritis (OA) because MMP13 preferentially cleaves type II collagen, the main component of cartilage, and both MMP13 levels and enzymatic activity are enhanced in OA.
  Chromatin and maintenance of genome stability
  Dr A Chambers
Applications accepted all year round
Within eukaryotes, DNA is packaged into chromatin. The basic unit of chromatin is the nucleosome, formed by the wrapping of ~147 bp of DNA around an octamer of histones proteins.
  Understanding transcription mediated methylation of intragenic CpG islands in health and disease
  Dr C Tufarelli, Prof S Cowley
Application Deadline: 5 May 2019
1. Project outline describing the scientific rationale of the project (max 4,000 characters incl. spaces and returns). DNA methylation is an epigenetic modification that affects gene expression without altering gene sequences.
  Molecular analysis of neutrophil extracellular traps (NETs) in rheumatoid arthritis
  Dr HL Wright, Prof RJ Moots
Applications accepted all year round
Neutrophil extracellular traps (NETs) kill pathogens via the release of chromatin and anti-microbial granule enzymes in an extracellular mesh or “net”.
  Epigenetic regulation in heart failure and cardiac sudden death
  Dr X Wang, Dr V Liu
Applications accepted all year round
A large proportion of heart failure patients die from cardiac sudden death (SCD), a direct result of lethal ventricular arrhythmias, which is the principal cause of mortality from heart disease worldwide and remains a major unresolved public health problem.
  Centromere inheritance in S. pombe and beyond
  Dr L Subramanian
Applications accepted all year round
Accurate chromosome segregation relies on the stable inheritance of functional centromeres through generations. A key determinant of centromere function is the histone H3 variant CENP-A (Centromere Protein A), that epigenetically marks and specifies active centromeres.
  Evolution Education Trust PhD project: Evolution of virulence hot-spots in parasitic nematode genomes
  Research Group: Evolution
  Dr H-W Nützmann, Dr V Hunt
Application Deadline: 30 April 2019
The University of Bath is inviting applications for this PhD opportunity based at the Milner Centre for Evolution, a unique, cross-faculty research centre bridging biology, health and education.
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