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histone PhD Projects, Programs & Scholarships

We have 23 histone PhD Projects, Programs & Scholarships

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  Cryo-Electron Microscopy of Histone Deacetylase Complexes
  Prof J Schwabe, Dr S Cowley
Application Deadline: 7 June 2020

Funding Type

PhD Type

Histone deacetylase complexes play a role in many cellular processes, such as cancer, cell cycle progression and DNA repair. Investigating how these HDAC complexes act to control gene expression and their interactions with other proteins should lead to an understanding of their influence in the cell.
  Is epigenetic information is exchanged between sister chromatids to restore chromatin structure and maintain epigenetic information after DNA replication?
  Dr N Francis
Applications accepted all year round

Funding Type

PhD Type

DNA in eukaryotic cells is organized into chromatin. Far from being an inert packing material, chromatin is a rich source of information for gene regulation.
  Exploring the role of histone deacetylase inhibitors as regulators of innate immune cells activation in periodontitis
  Dr F Flores-Borja
Applications accepted all year round

Funding Type

PhD Type

Second Supervisor. Rommel Chacon-Salinas (National Polytechnic Institute, Mexico). Background.
  Gene Regulation by the KAT6A/MOZ Histone Acetyltransferase
  Prof D Heery
Applications accepted all year round

Funding Type

PhD Type

The human KAT6A and KAT6B genes encode the nuclear proteins MOZ and MORF, which are key gene regulators in development of blood, brain and other tissues.
  Molecular mechanisms of genomic imprinting in an insect
  Dr E Mallon, Dr C Tufarelli, Dr E Rosato
Application Deadline: 7 June 2020

Funding Type

PhD Type

Genomic imprinting is a phylogenetically widespread phenomenon, and genes have been shown to be imprinted in mammals, plants, and fungi, as well as insects.
  Tumor-promoting roles of the chromatin-associated DEK oncogene in metastatic melanoma
  Dr F Kappes, Prof C Eyers
Applications accepted all year round

Funding Type

PhD Type

The candidate should have a master’s degree (or equivalent qualification) in biochemistry, cell biology or a life-science related discipline.
  The role of phase separation in epigenetic inheritance by Polycomb Group proteins.
  Dr N Francis
Applications accepted all year round

Funding Type

PhD Type

In recent years, the role of phase separation in organizing macromolecules in cells is increasingly appreciated. This includes the organization of chromatin into physical and functional domains.
  Deciphering a novel anti-ageing epigenetic programme
  Dr G Poulin, Prof A Sharrocks
Applications accepted all year round

Funding Type

PhD Type

Over two decades of intense research in the field of epigenetics have produced compelling evidence that chromatin modifications are crucial for processes such as DNA repair, transcription, splicing, mitosis, meiosis, and in the preservation of the epigenetic memory of cells.
  Epigenetic regulation in heart failure and cardiac sudden death
  Dr X Wang, Dr V Liu
Applications accepted all year round

Funding Type

PhD Type

A large proportion of heart failure patients die from cardiac sudden death (SCD), a direct result of lethal ventricular arrhythmias, which is the principal cause of mortality from heart disease worldwide and remains a major unresolved public health problem.
  Methionine adenosyltransferases in disease and regulation of gene expression
  Dr S Antonyuk, Prof S Hasnain
Applications accepted all year round

Funding Type

PhD Type

Transmethylation, the transfer of a methyl group from one molecule to another, is a fundamental chemical reaction that plays a central role in important biological processes such as gene expression, cell growth and apoptosis.
  Redeploying Rucaparib: Can PARP inhibitors alter deregulated cellular bioenergetics and overcome apoptosis resistance in cancer? (SF20/APP/WALDEN)
  Dr H Walden
Applications accepted all year round

Funding Type

PhD Type

Poly(ADP-ribose) polymerase inhibitors (PARPi) have received huge attention in oncology over recent years. They are FDA approved for use in BRCA1/2 defective breast and ovarian cancers with absent or dysfunctional homologous recombination repair function.
  RNA Methylation in normal and malignant blood development
  Dr L. Kats
Applications accepted all year round

Funding Type

PhD Type

As is the case with DNA and histones, RNA can also be modified and indeed more than 100 chemical groups that decorate all four canonical RNA nucleotides have been described.
  Epigenetic mechanisms of behavioural, placental and cognitive impairment in a neurodevelopmental model for schizophrenia
  Dr R Hager, Prof J Neill, Dr J Glazier
Applications accepted all year round

Funding Type

PhD Type

A fundamental question in disease research is how stressors experienced during critical developmental periods influence the genesis or ‘programming’ of adult disease (Estes & McAllister 2016).
  Epigenetic mechanisms of phenotypic plasticity and the evolution of adaptive responses
  Dr R Hager, Prof J McInerney
Applications accepted all year round

Funding Type

PhD Type

We now live in a world of rapidly changing environmental conditions where species will need to adapt or perish. While populations may evolve in response to environmental change, more rapid responses may happen through processes like phenotypic plasticity.
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round

Funding Type

PhD Type

The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
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