Macrophages are cells of the innate immune system that have the essential functions of eliminating infectious agents, removing infected, dying and dead cells, and inducing, regulating and resolving inflammation.
Investigating the molecular biology of activation and regulation of innate immune receptors that survey the cytosol, using a variety of virus infection models including influenza A virus, HIV and other retroviruses, flaviviruses such as Zika virus, and herpes viruses.
Viruses frequently hijack cellular processes as part of their life cycle. A recent proteomics screen revealed a core of mammalian proteins which are targeted by multiple viruses, defining four critical cellular nodes in viral infections (Nature 487:486-490).
Supervisors. Dr S Pushpakom. Prof M Bushell. Prof Sir M Pirmohamed. Background. Diabetes, obesity and cardiovascular disease (collectively called cardiometabolic disease) remain a major public health problem worldwide.
One of this project ‘s strengths is the novel computational technology it introduces to the paramount field of biocatalysis. Any quantum mechanical insight into enzymes is initially holistic in character, that is, energies and electron densities are calculated for the whole systems.
Human cytomegalovirus (HCMV) is an exciting vaccine vector. This comes from the demonstration that it can protect against both HIV and TB, in macaque models, the only vaccine vector to ever achieve this impressive feat.