A unique opportunity to join a vibrant research community developing guidance for states and businesses on how to integrate gender issues in their implementation of the UN Guiding Principles on Business and Human Rights.
Chemical flame retardants (FRs) such as polybrominated diphenyl ethers (PBDEs) and chlorinated organophosphates (e.g. tris (2-chloroisopropyl)phosphate – TCIPP) have been used extensively in a wide range of applications worldwide.
De novo mutations (DNMs) are a significant contributor to human disease, affecting ~1:300 new births. We study the mechanisms by which these spontaneous mutations arise in the first instance, concentrating on the tissue where most of them originate, the human testis.
The human brain is arguably the most complex structure among living organisms. Its development from single cells into a highly elaborate and unique organ has intrigued scientists for generations, yet remains incompletely understood.
In collaboration with the Scottish Human Rights Commission (SHRC) this project seeks to synthesise existing concepts of what constitutes a minimum core in the realisation of economic, social and cultural (ESC) rights as they potentially apply to Scotland, drawing on sociological, legal, and philosophical literatures.
Project background. Regulation of proteostasis is critical for maintaining tissue homeostasis. Autophagy, a major intracellular degradation pathway essential for cellular and energy homeostasis, functions in the clearance of aggregation-prone proteins and damaged organelles.
MRC Centre for Inflammation Research
Dr P Ramachandran, Prof N Henderson, Prof T Freeman
7 January 2019
Background. Chronic liver disease is estimated to affect 844 million people worldwide, with over 2 million deaths per year. Liver fibrosis (or scarring) is a feature of advanced chronic liver disease of any aetiology and predicts adverse patient outcomes.