Hypertension commonly predisposes to many cardiovascular complications, including atrial fibrillation, heart failure and stroke. Importantly the heart is responsible for blood pressure yet suffers the consequences of uncontrolled hypertension.
Mechanistic target of Rapamycin (mTOR) and regulatory protein of TOR (Raptor) complexes (mTORC1) promote idiopathic- and hypoxic pulmonary hypertension (PH), facilitating pulmonary arterial smooth muscle cell (PASMC) growth, proliferation, and thus pulmonary vascular remodelling.
Outstanding graduate scientists are invited to apply for a PhD Studentship to study the molecular mechanisms that cause detrimental pulmonary vascular remodelling in babies born with univentricular hearts, and to develop treatments that will prevent this problem and protect the infant lungs through childhood.
"Heart failure is a leading cause of morbidity and mortality worldwide. The contractile cells of the heart, cardiomyocytes, possess many protective mechanisms, allowing them to withstand pathophysiological stresses.