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hypoxia PhD Projects, Programs & Scholarships

We have 23 hypoxia PhD Projects, Programs & Scholarships

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We have 23 hypoxia PhD Projects, Programs & Scholarships

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Discovery of chemical and biological tools to probe hypoxic solid tumours

  Research Group: Institute of Cancer Therapeutics
A major challenge in cancer therapy is to develop therapeutic agents that selectively target tumour cells. One avenue towards the development of more selective cancer therapies is to exploit the unique physiological properties of solid tumours using prodrug approaches. Read more

(Clinical) Radiogenomic biomarkers in chemoradiation for cervical cancer

Successful treatment of locally advanced cervix cancer remains a challenge despite advances in chemoradiation. At the Christie Hospital we have one of only two 1.5T MR Linacs and with this have successfully delivered radical courses of chemoradiation for cervical cancer. Read more

Role for deSUMOylation Enzyme SENP3 in the Regulation of Pexophagy Linked to Peroxisomal Biogenesis Disorders

Peroxisomal Biogenesis Disorders (PBDs) such as Zellweger syndrome (1) refers to a group of diseases caused by genetic mutations in one of the membrane proteins (PEXs) responsible for biogenesis of the peroxisomes. Read more

Characterisation of DNA-protein crosslink proteolysis repair in cancer therapy with the focus on trapped-PARP1 toxicity

DNA-protein crosslinks (DPCs) are under-investigated DNA lesions caused by the covalent attachment of proteins to DNA. DPCs are induced by endogenous aldehydes, chemotherapeutic drugs (such as PARP1 inhibitors) and ionising radiation in hypoxic cells. Read more

(Leeds-Manchester Clinical) HPV-related penile squamous cell carcinoma morphology and evolution heterogeneity

Penile cancer is a squamous cell carcinoma (PSCC) is a rare tumour with almost no patient or funder advocacy programmes and constitutes1–2% of male cancer in the developing world; this hinders the broad study of its biology by scientists worldwide and contributes to lack of tailored treatments. Read more

Deciphering the metabolic determinants of bone metastasis in breast cancer

Project Description . Metastasis is the dissemination and formation of secondary tumours at distal sites that causes most of the morbidity and mortality associated with breast cancer and most other cancer types [1, 2]. Read more

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