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hypoxia PhD Projects, Programs & Scholarships

We have 31 hypoxia PhD Projects, Programs & Scholarships

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  Elucidation of the role of newly discovered post-translational modification of proteins involved in hypoxia signalling using proteomic analysis and live cell imaging
  Dr V See, Prof C E Eyers
Applications accepted all year round
The hypoxia signalling pathway is required for the adaptation of cells to a low oxygen environment, which cells can experience in various physiological and pathological circumstances related to high altitude, development, wound healing and cancer.
  Role of hypoxia in promotion of higher grade glioblastoma
  Research Group: Institute of Cancer Therapeutics
  Dr V Vinader, Dr K Afarinkia
Applications accepted all year round
Glioblastomas are categorized into four grades. Grade I is essentially benign and slow growing, and most amenable to treatment. Grade II tumors are larger and invade surrounding tissue.
  MRC DiMeN Doctoral Training Partnership: Mass-spectrometry analysis and live cell/zebrafish imaging to discover the function of novel post-translational modifications occurring in hypoxia signalling
  Dr V See, Prof C Eyers, Dr P Elks, Prof S Rocha
Application Deadline: 21 January 2019
To survive, multicellular organism need to sense and respond to changes in oxygen level. Episodes of low oxygen (hypoxia) occur during many physiological processes and also in pathological circumstances such as stroke, ageing and cancer.
  Regulation of the In Vivo Response to Cardiac Hypoxia – The Role of FIH1
  Dr M Cole
Applications accepted all year round
Hypoxia-inducible factors (HIFs) are transcription factors present in all mammalian cells, and play a pivotal role in the molecular response to changes in oxygen availability.
  Hypoxia-Targeted Protein-Targeting Chimeras (htPROTACS)
  Prof E Hammond, Dr S Conway
Application Deadline: 11 January 2019
Protein-targeting chimeras (PROTACS) are bifunctional molecules that hijack the cellular machinery for protein degradation, via the ubiquitination pathway, to target the degradation of a defined target protein.
  Discovery of chemical and biological tools to probe hypoxic solid tumours
  Research Group: Institute of Cancer Therapeutics
  Dr K Pors, Dr J Elies Gomez
Applications accepted all year round
A major challenge in cancer therapy is to develop therapeutic agents that selectively target tumour cells. One avenue towards the development of more selective cancer therapies is to exploit the unique physiological properties of solid tumours using prodrug approaches.
  Therapeutic exploration of the radiobiological tumour
  Dr I Pires
Application Deadline: 23 January 2019
Adaptive Radiotherapy. Engineering the radiobiological tumour for improved radiation success. To celebrate the University's research successes, the University of Hull is offering a full-time UK/EU/International PhD Scholarship for candidates applying for each of the following projects as part of a new research cluster.
  Deciphering the regulation of non-coding RNAs in a hypoxic tumour microenvironment
  Prof F Buffa, Prof A Harris
Application Deadline: 11 January 2019
The role of the microenvironment in driving tumour progression is increasingly recognized. Hypoxia is one of the key microenvironmental changes between tumour and normal tissue, and adaptation of cancer cells to this hostile environment contributes to their malignancy and aggressive phenotype (1).
  Parallels between wound healing and cancer – role of epithelial to mesenchymal transition (EMT)
  Research Group: Centre for Skin Sciences
  Dr M J Thornton, Prof A M Graham
Applications accepted all year round
Wound healing and cancer metastasis share common early signalling pathways that have led to the hypothesis that tumours are “wounds that do not heal”, a phrase first coined by Virchow in the 19th century.
  Adaptations to life at high altitude in Canary Island bats
  Dr O Razgour, Dr M Chapman
Application Deadline: 4 January 2019
Global climate change is predicted to result in species shifting their ranges up latitudinal and altitudinal gradients to track suitable climatic conditions.
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