Overview. Immune checkpoint pathways determine the abilities of human malignant tumours to escape cytotoxic immune attack and thus progress the disease. Read more
Overview. Immune checkpoint pathways determine the abilities of human malignant tumours to escape cytotoxic immune attack and thus progress the disease. Read more
This exciting project will commence in September 2022 and has funding for 3 years. The student will be based primarily at the Barts Cancer Institute, Faculty of Medicine and Dentistry (FMD), Charterhouse Square in the City of London. Read more
The immune system must be primed to quickly respond to infection, but must also be tightly regulated so it ignores harmless substances and our own tissues. Read more
Overview. The human Immune system is designed to protect against harmful pathogens but the function of the immune system deteriorates with age. Read more
Immune “cold” tumours are tumours with little infiltrations of T lymphocytes and therefore immune suppressed, developed by a mechanism of evasion from immune surveillance through cancer progression (Hallmarks of Cancer). Read more
The innate immune system can display characteristics of immunological memory. This phenomenon, termed “trained immunity”, refers to the long-term functional reprogramming of innate immune cells after the encounter with infectious or non-infectious agents that influences their capacity to respond to a secondary stimulus. Read more
The innate immune system can display characteristics of immunological memory. This phenomenon, termed “trained immunity”, refers to the long-term functional reprogramming of innate immune cells after the encounter with infectious or non-infectious agents that influences their capacity to respond to a secondary stimulus. Read more
Blood cell differentiation is one of the best characterised models to study how normal tissue-specific stem cells give rise to diverse cell types. Read more
Blood cell differentiation is one of the best characterised models to study how normal tissue-specific stem cells give rise to diverse cell types. Read more
Summary. Cytotoxic T cells have the capability of killing tumour target cells. However, this ability is commonly suppressed within the tumour microenvironment. Read more
Successful long-term tissue regeneration of any human organ beyond the experimental state remains elusive. Given that the immune system plays a key role in tissue regeneration, including in the CNS, one of the most promising novel approaches is to integrate endogenous immune mechanisms into regenerative strategies. Read more
Your innate immune system is the first line of defence against infections, cancer and various physiological danger signals. Innate immune dysregulation is a central driver of various pathologies ranging from neurological diseases to immunological and metabolic disorders and cancers. Read more
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