Immune dysregulation and impaired gut mucosal barrier function are intimately linked features of two paediatric inflammatory gut disorders; namely graft-versus-host disease (GVHD) and necrotizing enterocolitis (NEC).
Human cytomegalovirus (HCMV) is an exciting viral vaccine vector, that can protect against HIV and cancer in animal models. However it is also a pathogen that causes significant disease and death on a worldwide level, mainly in transplant recipients and unborn babies.
Summary. Environmental enteric dysfunction (EED) affects 200 million children in low- and middle-income countries and has extremely detrimental consequences for long-term health.
Investigating the molecular biology of activation and regulation of innate immune receptors that survey the cytosol, using a variety of virus infection models including influenza A virus, HIV and other retroviruses, flaviviruses such as Zika virus, and herpes viruses.
Super-resolution microscopes, celebrated in the 2014 Nobel Prize for Chemistry, are one of the tools that allow us to study immune cells in unprecedented detail.
This PhD programme is a collaboration between A*STAR and Queen Mary University of London (QMUL) to provide research opportunities for PhD students at A*STAR Research Institutes.
Our immune system must fight harmful pathogens, but remain silent against harmless substances such as the trillions of bacteria found in the gut that are beneficial for health.
Development of the hematopoietic/ immune system in the embryo. Our aim is to obtain a mechanistic insight into the birth of hematopoietic stem and progenitor cells in embryonic development and determine the contribution of these cells to the emerging hematopoietic and immune systems of the embryo.
