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immunohistochemistry PhD Projects, Programmes & Scholarships
We have 30 immunohistochemistry PhD Projects, Programmes & Scholarships
We have 30 immunohistochemistry PhD Projects, Programmes & Scholarships
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4-year PhD Studentship: Chemogenetic modulation of neuronal activity as a refined alternative to physiological stress
High blood pressure is one of the biggest risk factors for cardiovascular disease (1). The hypothalamus regulates neuroendocrine homeostasis and helps to maintain metabolic processes such as body weight, fluid balance and blood pressure (2). Read more
SELF-FUNDING MSc BY RESEARCH PROJECT: Probing the projections of different types of dopamine neurons
What makes one neuron different from another? How can we define different “types” of cells? Are cell types important?. In Parkinson’s disease some dopamine neurons seem to be more vulnerable to neurodegeneration. Read more
The effects of Interleukin-1 primed mesenchymal stem cells on hypoxic-ischemic brain damage
Hypoxic-ischemic brain damage is one of the main causes of death and neurological disability after stroke worldwide. Read more
Fully Funded Dunhill Medical Trust Healthy lifespan Institute DTP Studentship: The role of adrenomedullin and its receptors in age-related in organ dysfunction.
This 3.5 year studentship is part of research within the Healthy Lifespan Institute (HELSI) at The University of Sheffield. HELSI is dedicated to the understanding and prevention of multimorbidity (the presence of two or more chronic health conditions that create disability and reduce quality of life). Read more
What is the contribution of basal ganglia pathology to late-life dementia and frailty?
This project focuses on the role of the basal ganglia in dementia using a cohort of autopsy-derived brain tissue. Most dementia in the population setting is multifactorial and, despite major recent advances, knowledge of the pathological basis of dementia stills remains incomplete. Read more
In situ analysis of the T-cell receptor repertoire in colorectal cancer
As cancer cells divide their DNA accumulates new mutations, some of which will lead to the generation of neoantigens – mutant peptides that can be recognised by immune cells as non-self. Specific (neo)antigen recognition is mediated by T cell receptors (TCRs), which are encoded by a hypervariable sequence that is unique to a TCR clone. Read more
Synergist effects of krill oil and krill protein on muscle mass/function and muscle protein metabolism
The age-related loss of muscle mass and function, sarcopenia, has several deleterious effects, such as a reduction in the quality of life and increased incidence of falls, often leading to hospitalisation. Read more
The role of PHF6 during haematopoietic differentiation
PHD finger protein 6 (PHF6) is a protein, consisting of two atypical plant homeodomains (aPHD1/2) with nuclear and nucleolar localization sequences. Read more
Transcription factor complexes in Acute Myeloid Leukaemia
Acute Myeloid Leukaemia (AML) is a group of blood cancers, resulting from uncontrolled cellular proliferation of cells belonging to the myeloid lineage. Read more
Innate Immune Reprogramming in Atherosclerosis
The Hospital of the University of Munich, Germany, is one of the largest and most competitive university hospitals in Germany and Europe. Read more
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Understanding the role of the hippo signalling pathway in ependymoma tumour biology
Ependymomas are tumours of the brain and spinal cord which affect paediatric and adult patients, representing the third most common malignant brain tumour in children. Read more
Deciphering the landscape of nucleoporin and lamin function in nucleocytoplasmic communication, nuclear scaffolding and transcriptional control in disease prevention
The nucleus has an instrumental role in cellular responses by coordinating shuttling of components in and out of the nucleus and gene expression with genome architecture and stability. Read more
Deciphering the landscape of nucleoporin and lamin function in nucleocytoplasmic communication, nuclear scaffolding and transcriptional control in disease prevention
The nucleus has an instrumental role in cellular responses by coordinating shuttling of components in and out of the nucleus and gene expression with genome architecture and stability. Read more
Metabolic reprogramming in cancer: starving tumors of essential nutrients to promote cell death
All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow. Read more
Creating microcarriers for improving the survival and integration of cells transplanted to the brain.
For neurodegenerative diseases such as Parkinson’s disease, where a specific cell type is lost, it is possible to consider replacing these cells to restore the lost function. Read more
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