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immunotherapy PhD Projects, Programmes & Scholarships

We have 32 immunotherapy PhD Projects, Programmes & Scholarships

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We have 32 immunotherapy PhD Projects, Programmes & Scholarships

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Immunotherapy: Killing Cancer using Dead Virus

It is now accepted that our immune systems can hold the key to treating otherwise incurable cancers. So-called “immunotherapy” is an increasingly common method of treating tumours, leading to impressive increases in patient responses. . Read more

Pioneering a novel cancer targeting glyco-immunotherapy strategy

Background. Human cells are coated in a thick layer of sticky sugars called the glycocalyx. Uniquely cancer cells are covered with an excess of the human ‘sialic acid’ sugar Neu5Ac, and this has been shown to ‘camouflage’ the cells from the immune system. Read more

Immunotherapy: Manipulating T cell metabolism to improve anti-tumour immunity

The induction of immune responses to tumours can provide long-lasting protection from cancer. In this regard, T cells can suppress tumour growth by directly killing cancer cells and by producing inflammatory cytokines. Read more

Validation of TRAF6/PD-L1 inhibition in pre-clinical models of multiple myeloma: implications for combinational immunotherapy

Programmed death-ligand 1(PD-L1), a negative regulator of the immune system, is highly expressed in newly-diagnosed and relapsed multiple myeloma patients, and its expression is associated with suppressed anti-tumour immunity. Read more

MSc by Research: Immunotherapy against trypanosomiasis: Proof of concept

Drug discovery for parasitic diseases remains a major challenge and global health need. Significant advances in screening technology and methods to understand the mode of action in the past decade have contributed hugely to our arsenal of biological tools to control these pathogens. Read more

Promoting cancer cell’s antigen presentation for serving as better targets for T cell immunotherapy

Commercial partner: . Oxford Vacmedix UK Ltd (OVM). , Oxford. Cytotoxic T cells (CTLs), which kill tumour cells upon recognition of antigenic peptides presented by the major histocompatibility complex (MHC) on the cell surface, are the goal of precision medicine including immunotherapies. Read more

Immune modulation by checkpoint receptor targeting

Commercial partner: . MiroBio Ltd / Gilead Sciences. , Oxford. Signalling by inhibitory co-receptors, also termed immune checkpoint receptors, such as PD-1, reduces T cell function and promotes T cell exhaustion, compromising the immune response to pathogens and cancer cells. Read more

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