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induced pluripotent stem cells PhD Projects, Programmes & Scholarships

We have 20 induced pluripotent stem cells PhD Projects, Programmes & Scholarships

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We have 20 induced pluripotent stem cells PhD Projects, Programmes & Scholarships

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An omics approach to understand and treat KMT2C-related neurodevelopmental disorder using induced pluripotent stem cells and CRISPR-Cas9

Background. We recently identified a novel human syndrome caused by mutations in a gene called KMT2C1. Patients with this condition predominantly have developmental delay and intellectual disability indicating the important function of this gene in brain’s normal development and function. Read more

Understanding why cardiovascular dysfunction is one of the leading causes of mortality in patients with Non-Alcoholic Fatty Liver disease (NAFLD)

Background. Liver disease accounts for 3.5% of all global deaths/year (~2 million people) and is the third leading cause of premature death in the UK with some of the highest hospitalisations in the country seen in areas of socioeconomic deprivation. Read more

Single-Cell Lineage Mapping of Elite CAR-NK Cells

The advance of chimeric antigen receptor (CAR) technology has been a breakthrough in cancer immunotherapy. However, it is not clear in which subpopulation of immune cells the endowment of CAR will be most effective in treating cancer. Read more

A role for cholesterol metabolism in neurodevelopmental disorder

Microdeletions and duplications of the chromosome 15q11.2 region have been identified as a high penetrant risk copy number variance (CNV) to autism and schizophrenia. CYFIP1 (Cytoplasmic FMR1-interacting protein 1) is generally believed to be the causal risk gene in this CNV. Read more

Deriving functional neurons from hIPSCs

Neuronal networks grown on petri dishes encode information as electrical activity. This activity is dictated by their underlying structural and functional connectivity. Read more

Growth factor isoforms in neural and pancreatic beta cell differentiation

Disorders in which specific cells malfunction and degenerate, such as diabetes and neurodegenerative disease, are a huge unmet health need for which there are currently no curative treatments. Read more

The Mechanisms of Epigenetic Regulation in Ageing and Age-Related Neurodegeneration

We are seeking a bright, talented, and highly motivated PhD student to lead a project investigating basic mechanisms of epigenetic regulation and their involvement in ageing and age-related neurodegeneration. Read more

Bioengineering a full thickness cornea

Corneal blindness is the 4th leading cause of global blindness (WHO). Corneal scarring can be caused by trauma or infection and corneal replacement with donor corneas or synthetic (plastic) alternatives is currently the sole treatment to restore vision. Read more

Epigenetic regulation in heart failure and cardiac sudden death

A large proportion of heart failure patients die from cardiac sudden death (SCD), a direct result of lethal ventricular arrhythmias, which is the principal cause of mortality from heart disease worldwide and remains a major unresolved public health problem. Read more

Investigating intracellular signalling mechanisms in the hippocampus: implications in memory formation and disease

Rationale. MicroRNAs (miRNA) are non-coding RNAs that mediate the silencing of specific messenger RNAs. miRNAs are involved in the regulation of all cellular processes and they are particularly important in coordinating gene expression and function in neurons (1). Read more

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