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We have 20 induced pluripotent stem cells PhD Projects, Programmes & Scholarships

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induced pluripotent stem cells PhD Projects, Programmes & Scholarships

We have 20 induced pluripotent stem cells PhD Projects, Programmes & Scholarships

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An omics approach to understand and treat KMT2C-related neurodevelopmental disorder using induced pluripotent stem cells and CRISPR-Cas9

Background. We recently identified a novel human syndrome caused by mutations in a gene called KMT2C1. Patients with this condition predominantly have developmental delay and intellectual disability indicating the important function of this gene in brain’s normal development and function. Read more

Stem cells and hungry neurons: neuropeptides in energy homeostasis

Summary. You will investigate the role of neural stem cells and neurons in energy homeostasis. You will determine how neuropeptides and diet affects stem cells, neurons and glia from mouse and human brain. Read more

PhD Studies with PACE – Protein and Cell Engineering Laboratory

PhD Studies with PACE – Protein and Cell Engineering Laboratory. “Tailored stem cell models to study and eventually cure degenerative diseases will be unlocked with engineered and enhanced biomolecules.”. Read more

Investigating the role of endothelial cells in myelin damage in Alzheimer's diseases using iPSC-derived model

Alzheimer’s disease (AD) affects around 50 million people globally with no cure. Apart from well-known neuronal loss, myelin abnormalities in brain have been recently detected from early stage of AD. Read more

Stem Cells: Developing pluripotent stem cell models of inherited retinal diseases

Inherited retinal dystrophies are a leading cause of blindness and visual loss in the UK working age population. However, despite the widespread diagnostic use of next-generation sequencing, a molecular genetic diagnosis is unavailable for many patients world-wide. Read more

Deriving functional neurons from hIPSCs

Neuronal networks grown on petri dishes encode information as electrical activity. This activity is dictated by their underlying structural and functional connectivity. Read more

Development of AI framework for iPSC image analysis and integration with transcriptomics

A fully funded PhD Studentship is available to work with Professor Viji Draviam, Professor of Quantitative Cell and Molecular Biology and Director of Industrial Innovation, School of Biological and Behavioural Science, Queen Mary University London, and Dr Victor Neduva, Senior Director, Genome and Biomarker Sciences, MSD. Read more

Epigenetic regulation in heart failure and cardiac sudden death

A large proportion of heart failure patients die from cardiac sudden death (SCD), a direct result of lethal ventricular arrhythmias, which is the principal cause of mortality from heart disease worldwide and remains a major unresolved public health problem. Read more

Epigenetic control of transcription factor regulation of adult neurogenesis in the dentate gyrus

In the adult brain, new neurons are continuously generated in the hippocampal dentate gyrus (DG). This neurogenesis process is highly regulated and consists of cell proliferation, neuronal differentiation, neuronal maturation and survival. Read more

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