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induced pluripotent stem cells PhD Projects, Programmes & Scholarships
We have 20 induced pluripotent stem cells PhD Projects, Programmes & Scholarships
We have 20 induced pluripotent stem cells PhD Projects, Programmes & Scholarships
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An omics approach to understand and treat KMT2C-related neurodevelopmental disorder using induced pluripotent stem cells and CRISPR-Cas9
Background. We recently identified a novel human syndrome caused by mutations in a gene called KMT2C1. Patients with this condition predominantly have developmental delay and intellectual disability indicating the important function of this gene in brain’s normal development and function. Read more
Mechanistic understanding of cancer drug induced cardiotoxicity using patient derived induced pluripotent stem cell (iPSC) derived cardiomyocytes
Background. Cardiovascular disease is the number one non-cancer cause of death in cancer survivors, attributable to side-effects of cancer medications routinely given to patients. Read more
Understanding why cardiovascular dysfunction is one of the leading causes of mortality in patients with Non-Alcoholic Fatty Liver disease (NAFLD)
Background. Liver disease accounts for 3.5% of all global deaths/year (~2 million people) and is the third leading cause of premature death in the UK with some of the highest hospitalisations in the country seen in areas of socioeconomic deprivation. Read more
Generating human diabetic blood vessel organoids as a powerful model to investigate and treat the diabetic vasculopathy
In this project induced pluripotent stem cells will be derived diabetic patient specific blood vessel organoids. Read more
The generation of RBCs in vitro from stem cell sources and the molecular regulation of erythropoiesis in health and disease: towards new therapeutic approaches
Development of systems for the generation of red blood cells (RBCs) from stem cell sources (adult peripheral blood, cord blood and induced pluripotent stem… Read more
Single-Cell Lineage Mapping of Elite CAR-NK Cells
The advance of chimeric antigen receptor (CAR) technology has been a breakthrough in cancer immunotherapy. However, it is not clear in which subpopulation of immune cells the endowment of CAR will be most effective in treating cancer. Read more
4-year PhD Studentship: Control of neuronal differentiation and ciliogenesis through mineralocorticoid receptor (MR) – Regulatory Factor X (RFX) interaction in embryonic and adult neurogenesis
Glucocorticoid hormones (GCs) are of critical importance for health[1]. They bind to two receptor types in the hippocampus. the mineralocorticoid (MR) and glucocorticoid receptor (GR) which act as ligand-dependent transcription factors[2-4]. Read more
A role for cholesterol metabolism in neurodevelopmental disorder
Microdeletions and duplications of the chromosome 15q11.2 region have been identified as a high penetrant risk copy number variance (CNV) to autism and schizophrenia. CYFIP1 (Cytoplasmic FMR1-interacting protein 1) is generally believed to be the causal risk gene in this CNV. Read more
Characterisation of the neuronal receptor for soluble amyloid precursor protein: a route to new therapeutic targets for Alzheimers disease
Alzheimer’s disease (AD) is the commonest form of dementia for which currently there is no means of stopping or even slowing the disease. Read more
Deriving functional neurons from hIPSCs
Neuronal networks grown on petri dishes encode information as electrical activity. This activity is dictated by their underlying structural and functional connectivity. Read more
Growth factor isoforms in neural and pancreatic beta cell differentiation
Disorders in which specific cells malfunction and degenerate, such as diabetes and neurodegenerative disease, are a huge unmet health need for which there are currently no curative treatments. Read more
The Mechanisms of Epigenetic Regulation in Ageing and Age-Related Neurodegeneration
We are seeking a bright, talented, and highly motivated PhD student to lead a project investigating basic mechanisms of epigenetic regulation and their involvement in ageing and age-related neurodegeneration. Read more
Bioengineering a full thickness cornea
Corneal blindness is the 4th leading cause of global blindness (WHO). Corneal scarring can be caused by trauma or infection and corneal replacement with donor corneas or synthetic (plastic) alternatives is currently the sole treatment to restore vision. Read more
Epigenetic regulation in heart failure and cardiac sudden death
A large proportion of heart failure patients die from cardiac sudden death (SCD), a direct result of lethal ventricular arrhythmias, which is the principal cause of mortality from heart disease worldwide and remains a major unresolved public health problem. Read more
Investigating intracellular signalling mechanisms in the hippocampus: implications in memory formation and disease
Rationale. MicroRNAs (miRNA) are non-coding RNAs that mediate the silencing of specific messenger RNAs. miRNAs are involved in the regulation of all cellular processes and they are particularly important in coordinating gene expression and function in neurons (1). Read more
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