Investigating the molecular biology of activation and regulation of innate immune receptors that survey the cytosol, using a variety of virus infection models including influenza A virus, HIV and other retroviruses, flaviviruses such as Zika virus, and herpes viruses.
Macrophages are effector cells that directly kill microbes and regulatory cells that coordinate the wider immune response. Due to the complex nature of macrophage function, how their different roles are integrated during infection and inflammation is still poorly understood.
Parasitic worms (helminths) infect most mammals including a third of the human population. Although rarely causing death, these parasites cause significant morbidity in part by the damage they inflict while migrating through the tissues.