We study how iron and anaemia influence immunity and infectious diseases. Our research inspires therapies that control iron physiology to improve immunity, combat infections and treat disorders of iron metabolism.
Sepsis is a life-threatening illness that is triggered by an exaggerated immune response to severe infection. This unbalanced reaction induces hyperinflammation, shock and organ dysfunction that forms the primary cause of death in hospitalised patients.
Human cytomegalovirus (HCMV) is an exciting viral vaccine vector, that can protect against HIV and cancer in animal models. However it is also a pathogen that causes significant disease and death on a worldwide level, mainly in transplant recipients and unborn babies.
Parasitic worms (helminths) infect most mammals including a third of the human population. Although rarely causing death, these parasites cause significant morbidity in part by the damage they inflict while migrating through the tissues.