Coccidia are obligate intracellular parasites that undergo their endogenous development within a specialised structure called the parasitophorous vacuole (PV) that is formed during the process of zoite invasion.
Investigating the molecular biology of activation and regulation of innate immune receptors that survey the cytosol, using a variety of virus infection models including influenza A virus, HIV and other retroviruses, flaviviruses such as Zika virus, and herpes viruses.
Background. This interdisciplinary project bridges world-leading labs with expertise in bacterial cell biology and infection. Novel therapies are needed to overcome increasing antibacterial resistance.
Parasitic worms (helminths) infect most mammals including a third of the human population. Although rarely causing death, these parasites cause significant morbidity in part by the damage they inflict while migrating through the tissues.