Ubiquitination is a fundamental post-translational modification (PTM) crucial for a wide range of cellular processes, including protein degradation, localization, quality control, DNA repair, cell signaling, and immune responses. Read more
Ubiquitination is a fundamental post-translational modification (PTM) crucial for a wide range of cellular processes, including protein degradation, localization, quality control, DNA repair, cell signalling, and immune responses. Read more
1 in 6 couples experience infertility and many will need active treatment such as in vitro fertilisation (IVF). This involves stimulation of the woman’s ovaries to enable maturation of her eggs which are collected and fertilised with the male partner’s sperm to create embryos. Read more
Infertility is a global concern, affecting approximatively 1 in 6 couples who are trying to conceive. In vitro fertilisation (IVF) is an effective fertility treatment; however, worldwide only a privileged 2% of the clinically infertile can access IVF. Read more
A defining aspect of life is the accurate transmission of genetic information from one generation of cells to the next. During mitosis, chromosomes are reorganised dramatically into discrete cylindrical entities. Read more
Germline cells throughout metazoans are connected together in a cyst through intercellular bridges, made of microtubules and stabilized by a channel protein structure. Read more
In mammals, the formation of sperm and eggs is crucial for initiating a new life cycle. The first step in this developmental process is the specification of primordial germ cells (PGCs) in the early post-implantation embryo. Read more
This project investigates the impact of natural genetic variations on a specific G protein-coupled receptor (GPCR), focusing on its structure, function, and drug interactions. Read more
The nucleus has an instrumental role in cellular responses by coordinating shuttling of components in and out of the nucleus and gene expression with genome architecture and stability. Read more
The nucleus has an instrumental role in cellular responses by coordinating shuttling of components in and out of the nucleus and gene expression with genome architecture and stability. Read more
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