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infertility PhD Projects, Programmes & Scholarships
We have 7 infertility PhD Projects, Programmes & Scholarships
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Unravelling the effects of mitochondrial replacement therapy on mtDNA transmission
Commercial partner: Juno Genetics. Normal oocytes contain ~100,000 copies of mtDNA, which are effectively identical. Patients with mtDNA disease may harbour both mutant and normal mtDNA (heteroplasmy). Read more
Calcium signalling in In-Vitro Fertilization: developing a non-invasive diagnostic tool using mathematical modelling and data analysis
IVF is the primary treatment of infertility with ~2.5 million treatments and ~500,000 births annually. The success rate has been ~25% for many decades but it has been decreasing while the IVF industry is projected to grow to 37.7 billion (USD) by 2027 with an ~10% annual growth rate. Read more
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Structural investigation of chromatin organisation in development
The genome of the fertilised zygote undergoes rapid remodelling in order to develop into a multicellular embryo. Of these events, the reprogramming of chromatin structure is essential to generate totipotency - the capacity to form the whole organism including all embryonic and extraembryonic cell types. Read more
Structure-based design of allosteric modulators for G protein-coupled receptors using molecular modelling and pharmacology experiments
Almost all physiological processes are regulated through the activation of G protein-coupled receptors (GPCRs). It has become widely accepted that most GPCRs possess binding sites spatially distinct from their natural ligand binding site (orthosteric site), termed as allosteric sites. Read more
Born Slippy: Understanding the tribological mechanisms of fertility treatments and their impact on conception
Infertility affects 186M women in the developed world, with approximately 55M attributed to tubal patency - this is a big problem! Hysterosalpingography or HSG is a diagnostic procedure that is also an effective treatment for tubal problems. Read more
Deciphering the landscape of nucleoporin and lamin function in nucleocytoplasmic communication, nuclear scaffolding and transcriptional control in disease prevention
The nucleus has an instrumental role in cellular responses by coordinating shuttling of components in and out of the nucleus and gene expression with genome architecture and stability. Read more
Deciphering the landscape of nucleoporin and lamin function in nucleocytoplasmic communication, nuclear scaffolding and transcriptional control in disease prevention
The nucleus has an instrumental role in cellular responses by coordinating shuttling of components in and out of the nucleus and gene expression with genome architecture and stability. Read more
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