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inhibitor PhD Projects, Programs & Scholarships

We have 26 inhibitor PhD Projects, Programs & Scholarships

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To develop an allosteric inhibitor of HDAC6 inhibition in cancer
Queen’s University Belfast School of Pharmacy
The HDAC6 protein is upregulated in cancer and associated with increased proliferation and metastasis. Several HDAC6 inhibitors have been developed and are in clinical trials. Read more
 Supervisors: Dr F Furlong, Dr I Tikhonova
 Year round applications  PhD Research Project  Competition Funded PhD Project (European/UK Students Only)
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Molecular modelling insights into the performance of polymeric coatings containing active corrosion inhibitors
The University of Manchester Department of Chemical Engineering & Analytical Science
  Research Group: Multiscale Modelling
Sustainable Coatings by Rational Design (SusCoRD) is a multi-disciplinary project which aims to, for the first time, connect a detailed scientific understanding of the mechanisms of coatings failure with state-of-the-art-machine learning to deliver a framework for the optimisation of protective coatings and nanocomposite materials. Read more
 Supervisors: Dr F Siperstein, Prof X Zhou, Dr C Avendano
 22 July 2020  PhD Research Project  Funded PhD Project (European/UK Students Only)
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Neutrophils and Chemokine Signalling in the Tumour Immune Micro-environment and Progression
University of Glasgow College of Medicine, Veterinary and Life Sciences
Checkpoint inhibitor immunotherapy is promising, however still requires an improvement in response and development of markers to predict the patients who would benefit from this therapy. Read more
 Supervisor: Dr T Iwata
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Exploring the role of OGG1 in fibroblast senescence
University of Sheffield School of Clinical Dentistry
Fibroblasts are the major cell type of connective tissue. They play a critical role in maintaining the extracellular matrix, the ‘glue’ in which most cells reside, and maintaining normal function of other types of cells such as epithelial and immune cells. Read more
 Supervisors: Dr D Lambert, Prof T Helleday
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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A multiple modality approach for targeting treatment-resistant ovarian cancer
Peter MacCallum Cancer Centre Sir Peter MacCallum Department of Oncology, University of Melbourne
High-grade serous ovarian cancer (HGSOC) accounts for 70% of ovarian cancer (OvCa) deaths and its five-year survival rate is 43%. Read more
 Supervisors: Dr E. Sanij, Prof R. Pearson
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Metabolic Reprogramming in Liver Cancer: delineating the role of reactive oxygen species (ROS) in tumour development
Peter MacCallum Cancer Centre Sir Peter MacCallum Department of Oncology, University of Melbourne
The Tiganis Laboratory is seeking a highly enthusiastic student to conduct research in cancer metabolism and obesity-associated liver cancer. Read more
 Supervisor: Prof T. Tiganis
 Year round applications  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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mRNA translation reprogramming and metabolic re-wiring in response to ribosome-targeted therapies
Peter MacCallum Cancer Centre Sir Peter MacCallum Department of Oncology, University of Melbourne
Increased synthesis and activity of ribosomes are associated with oncogenesis downstream of the major oncogenes including MYC, RAS and PI3K. Read more
 Supervisors: Prof R. Pearson, Dr J Kang
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Development of small molecule inhibitors of FcεRI
Royal College of Surgeons in Ireland RCSI StAR International PhD Programme Research Projects
Allergic diseases are one of the most common diseases in the Western world. A report from the American academy of allergy, asthma and immunology indicated that between 40-50% of children are sensitized to at least one allergen. Read more
 Supervisors: Prof D Cox, Dr M Adamo
 Year round applications  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Design, Synthesis and Biological Evaluation of novel inhibitors of the JAK-STAT signalling pathway with potential application as immune oncology agents
The University of Manchester Department of Chemistry
Small molecule inhibitors of the JAK-STAT signalling pathway often possess interesting biological properties with many displaying potent anti-proliferative activity towards cancer cell lines. Read more
 Supervisors: Dr R Whitehead, Dr K Finegan, Prof N Turner
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Development of a rapid screening method for Carbapenemase-resistant Enterobacteriaceae using volatile and non-volatile metabolite profiles
The University of Manchester Faculty of Biology, Medicine and Health
Nosocomial infections caused by Enterobacteriaceae are a major concern to clinicians. Species include Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae, all of which are prevalent in ventilator-associated pneumonia. Read more
 Supervisors: Dr S Fowler, Dr T Felton, Dr W Ahmed
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Exploring the influence of proteogenomics in patients receiving biologic drugs for treatment of psoriatic arthritis
The University of Manchester Faculty of Biology, Medicine and Health
Background. Psoriatic arthritis (PsA) is an inflammatory arthritis, associated with the chronic skin condition psoriasis, which causes joint inflammation. Read more
 Supervisors: Prof A Barton, Dr James Bluett, Dr N Nair
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Immune phenotyping of refractory rheumatoid arthritis disease
The University of Manchester Faculty of Biology, Medicine and Health
Treatment of rheumatoid arthritis (RA) has been transformed with the introduction of targeted therapies twenty years ago (comprising biologic disease modifying anti-rheumatic drugs, bDMARDS; and the more recent small molecule JAK inhibitors). Read more
 Supervisors: Prof Maya Buch, Dr S Viatte
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Conformational dynamics and protein folding/misfolding of alpha1-antitrypsin studied by state-of-the-art tandem ion mobility mass spectrometry
University College London Department of Neuroscience, Physiology and Pharmacology
The protein A1AT is the most abundant circulating protease inhibitor. It is synthesised in the hepatocyte ER and its key target is the enzyme neutrophil elastase. Read more
 Supervisors: Prof K Thalassinos, Prof D Lomas
 26 June 2020  PhD Research Project  Funded PhD Project (UK Students Only)
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Tyrosine kinase inhibitors conjugated tumour targeting dyes for the treatment of glioblastoma.
University of Auckland School of Medical Sciences
Glioblastoma (GBM) remains a lethal and difficult to treat cancer with a dismal outcome. Although we have a better understanding of the disease progression, a concurrent increase in therapeutic intervention is lagging. Read more
 Supervisors: Dr J Jose, Dr P Choi
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Using single molecule spectroscopy to determine the drivers of conformational change in protein kinases
University of Bath Department of Pharmacy & Pharmacology
Protein kinases are central to many cellular processes (eg cell division and the response to external signals) and are current drug targets in cancer, cardiac and inflammatory disease. Read more
 Supervisor: Dr C Dodson
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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