We have 17 inhibitor PhD Projects, Programmes & Scholarships

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inhibitor PhD Projects, Programmes & Scholarships

We have 17 inhibitor PhD Projects, Programmes & Scholarships

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Assessment of matrix metalloproteinase 9 inhibitor for the treatment of severe skin-blistering adverse drug reactions using in vitro and ex vivo skin models.

Stevens-Johnson syndrome and toxic epidermal necrolysis are rare, immune-related, severe skin-blistering reactions which can be caused by a wide range of commonly administered drugs. SJS/TEN is characterised by wide-spread skin (epidermal) detachment and recent work in our lab has identified a number of potential molecular mechanism by which this could occur. Read more

Is there a Role for Activated Akt in Palatogenesis?

Main Aim. The project will use a medial edge epithelial (MEE) cell line as an in vitro model. These cells will be used to investigate the effects of exogenous TGFβ-3 and activation of Akt on cell migration, epithelial to mesenchymal transition (EMT) and apoptosis. Read more

Bifunctional small molecules beyond PROTACs: Proximity-inducing new downstream chemistries to rewire cell signalling

Proteolysis targeting chimeras (PROTACs) are a popular class of bifunctional molecules that simultaneously engage a target protein on one end and an E3 ubiquitin ligase on the other end, forming a ternary complex that facilitates the rapid ubiquitylation and subsequent degradation of the target protein. Read more

PhD in Neuroscience & Mental Health - Using a new translational in vivo model to understand the neurobiology underlying ADHD subtypes

Summary. In mice and humans loss-of-function of the steroid sulfatase (STS) enzyme results in inattention but enhanced motor response inhibition; we aim to understand the neurobiology underlying this dissociation using a new mouse model. Read more
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AI for selection of corrosion inhibitors: Enabling real-world in silico evaluation

This PhD provides an exciting and unique opportunity for someone to work at the interface between two quite different fields, namely corrosion control and pharmaceutical drug design, to test the following hypothesis. Read more

Therapeutic resolution of coronavirus (COVID-19) diseases by natural products

  Research Group: Pharmacology and Experimental Therapeutics
Coronavirus now labelled as Covid-19 has become a global pandemic affecting around 200 countries. Currently neither any cure nor any vaccine for Covid-19 has been established. Read more

Chemical glycoengineering of therapeutic antibodies

Glycosylation is the most common posttranslational protein modification. Recombinant therapeutic glycoproteins (RTGs) such as monoclonal antibodies (mAbs) are decorated with complex glycans that determine not only their efficacy but also other critical parameters such as in vivo half-life, stability and antigenicity. Read more

The Survivin Interactome in Health and Disease

Survivin is a small protein that is essential for life but that also contributes to disease, most notably cancer, in which its abnormal overexpression is linked to therapeutic resistance and metastasis. Read more

Mechanisms of cancer cell invasion

Epithelial cancers such as breast cancer become difficult to treat when they invade the surrounding tissues, eventually entering the blood stream and spreading to other parts of the body to form metastases. Read more

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