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We have 30 inhibitor PhD Projects, Programmes & Scholarships

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A synthetic biology approach to dissect the post-anaphase functions of mitotic kinases

Cell division is essential for life. The complex mechanochemical processes of chromosome segregation and cytokinesis are coordinated by the group of multifunctional protein kinases (mitotic kinases) such as Aurora kinases and Polo kinases under the master regulation of the cyclin-dependent kinases. Read more

Investigating novel molecular regulators of the brown adipocyte programme

Brown adipose tissue is an enigmatic tissue that plays an important role in energy metabolism. The increasing prevalence of obesity-related disorders has led to a growing need for therapeutic strategies to reverse diet-induced weight gain. Read more

Using novel ferronucleosides to study and regulate DNA replication in cells

Background. Replication of nucleic acid polymers like DNA is an essential process for all known forms of life. Furthermore, dysregulation and errors in DNA-replication are strongly linked with human diseases including cancer, as well as the process of cellular ageing. Read more

Validation of TRAF6/PD-L1 inhibition in pre-clinical models of multiple myeloma: implications for combinational immunotherapy

Programmed death-ligand 1(PD-L1), a negative regulator of the immune system, is highly expressed in newly-diagnosed and relapsed multiple myeloma patients, and its expression is associated with suppressed anti-tumour immunity. Read more

Investigating the cell biology of Neoparamoeba perurans, a causative agent of Amoebic Gill Disease, and its endosymbiont kinetoplastid, Perkinsela.

Amoebic gill disease (AGD), caused by the opportunistic amoebozoan parasite Neoparamoeba perurans, is a major disease in salmonid aquaculture [1-3] and there is an urgent need to mitigate the impact parasitic infections have on both fish welfare and sustainable growth in the sector. Read more

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