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inhibitor PhD Projects, Programmes & Scholarships
We have 17 inhibitor PhD Projects, Programmes & Scholarships
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Assessment of matrix metalloproteinase 9 inhibitor for the treatment of severe skin-blistering adverse drug reactions using in vitro and ex vivo skin models.
Stevens-Johnson syndrome and toxic epidermal necrolysis are rare, immune-related, severe skin-blistering reactions which can be caused by a wide range of commonly administered drugs. SJS/TEN is characterised by wide-spread skin (epidermal) detachment and recent work in our lab has identified a number of potential molecular mechanism by which this could occur. Read more
A Novel K+ Channel Target (KCNK13/THIK1) for Neurodegenerative Disorders: Understanding its mechanism of inhibition by small molecule drugs and biological therapeutics
Commercial partner: Cerevance. The student will be involved in an exciting multidisciplinary project aimed at determining the structural and molecular mechanisms of a range of novel inhibitors of the THIK1 K2P K+ channel. Read more
Is there a Role for Activated Akt in Palatogenesis?
Main Aim. The project will use a medial edge epithelial (MEE) cell line as an in vitro model. These cells will be used to investigate the effects of exogenous TGFβ-3 and activation of Akt on cell migration, epithelial to mesenchymal transition (EMT) and apoptosis. Read more
Bifunctional small molecules beyond PROTACs: Proximity-inducing new downstream chemistries to rewire cell signalling
Proteolysis targeting chimeras (PROTACs) are a popular class of bifunctional molecules that simultaneously engage a target protein on one end and an E3 ubiquitin ligase on the other end, forming a ternary complex that facilitates the rapid ubiquitylation and subsequent degradation of the target protein. Read more
Using long-read sequencing to identify new druggable targets in Multiple Myeloma (NDORMS 2024/4)
Work within the Cribbs lab focuses on developing novel technology and computational analysis frameworks that empower new modes of treatment for disease. Read more
GW4 BioMed2 MRC DTP PhD project: Developing new weapons to fight drug-resistant superbugs – targeting lipoteichoic acid biosynthesis
This project is one of a number that are in competition for funding from the GW4 BioMed2 MRC Doctoral Training Partnership which is offering up to 20 studentships for entry in September 2024. Read more
PhD in Neuroscience & Mental Health - Using a new translational in vivo model to understand the neurobiology underlying ADHD subtypes
Summary. In mice and humans loss-of-function of the steroid sulfatase (STS) enzyme results in inattention but enhanced motor response inhibition; we aim to understand the neurobiology underlying this dissociation using a new mouse model. Read more
Last chance to apply
GREEN CDT Corrosion Inhibition Strategies for Product Store Environment
This exciting CDT/PhD project is centred on developing a novel corrosion inhibition strategy with application to infrastructure for the storage of nuclear products. Read more
Regulation of gingival mast cells activity by valproic acid-potential to repurpose for treatment of periodontitis?
Background. Periodontitis or chronic inflammation of the tooth-supporting tissues caused by a dysbiotic biofilm is the main cause of tooth loss in the adult population. Read more
Last chance to apply
AI for selection of corrosion inhibitors: Enabling real-world in silico evaluation
This PhD provides an exciting and unique opportunity for someone to work at the interface between two quite different fields, namely corrosion control and pharmaceutical drug design, to test the following hypothesis. Read more
Therapeutic resolution of coronavirus (COVID-19) diseases by natural products
Research Group:
Pharmacology and Experimental Therapeutics
Coronavirus now labelled as Covid-19 has become a global pandemic affecting around 200 countries. Currently neither any cure nor any vaccine for Covid-19 has been established. Read more
Chemical glycoengineering of therapeutic antibodies
Glycosylation is the most common posttranslational protein modification. Recombinant therapeutic glycoproteins (RTGs) such as monoclonal antibodies (mAbs) are decorated with complex glycans that determine not only their efficacy but also other critical parameters such as in vivo half-life, stability and antigenicity. Read more
The Survivin Interactome in Health and Disease
Survivin is a small protein that is essential for life but that also contributes to disease, most notably cancer, in which its abnormal overexpression is linked to therapeutic resistance and metastasis. Read more
Functional Regulation of Microcephalin-1 in Mitosis and DNA Repair (ref: SF22/HLS/APP/JOWSEY)
The spectacular process of chromosome condensation reduces the overall length of genomic DNA from 2 metres to 0.2 millimetres, with each chromosome packaged… Read more
Mechanisms of cancer cell invasion
Epithelial cancers such as breast cancer become difficult to treat when they invade the surrounding tissues, eventually entering the blood stream and spreading to other parts of the body to form metastases. Read more
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