Despite significant advances in the understanding of the biology of blood cancers, identification of the most effective and safe form of treatment continues to present a formidable challenge to clinicians.
We work on characterising inter-individual variation in human immune responses. Checkpoint inhibitor immunotherapy has revolutionised the management of multiple cancers, yet our understanding of how the response to these treatments diverges between patients is limited.
We are looking for a motivated PhD student that would like to work on the following project funded by the ERC (European Research Council) Starting grant.
This PhD is part of the EPSRC Centre for Doctoral Training in "Materials for Demanding Environments" [CDT in M4DE], is sponsored by BP International Ltd and will commence October 2018.
Naturally occurring gas (mostly methane) hydrates along the continental margins (coastal offshore) and permafrost sediments are the clean source of energy outnumbering the rest forms of conventional energy sources.
The highly related histone deacetylases (HDAC) 1, 2 and 3 regulate global levels of lysine acetylation as the catalytic components of five distinct multi-protein complexes.
The oomycete potato pathogen Phytophthora infestans has caused devastation during the Irish Potato Famine in the 1840s. P. infestans still causes major problems in the potato industry, and is mostly controlled using agrochemicals.
The important cellular entities responsible for fighting against infections in our body are the T cells. T cells are however also shown to play a central role in the development of autoimmune diseases (AIDs) as “T cell activation hijacking” is the major autoimmune reaction causing mechanism observed in several AIDs.
