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inhibitor PhD Projects, Programmes & Scholarships
We have 30 inhibitor PhD Projects, Programmes & Scholarships
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A synthetic biology approach to dissect the post-anaphase functions of mitotic kinases
Cell division is essential for life. The complex mechanochemical processes of chromosome segregation and cytokinesis are coordinated by the group of multifunctional protein kinases (mitotic kinases) such as Aurora kinases and Polo kinases under the master regulation of the cyclin-dependent kinases. Read more
Functional characterisation of Siglec-15 as a new checkpoint inhibitor target
Tumours evolve many ways to gain survival advantage. New blood vessels are formed to deliver extra oxygen, nutrients and to assist mobilisation of… Read more
Evaluation of combination therapies targeting DNA damage repair signalling pathways in acute myeloid leukaemia
Acute myeloid leukaemia (AML) is an aggressive cancer affecting mostly adult and elderly patients. It has a very poor 5-year survival of <20% in the UK. Read more
Investigating novel molecular regulators of the brown adipocyte programme
Brown adipose tissue is an enigmatic tissue that plays an important role in energy metabolism. The increasing prevalence of obesity-related disorders has led to a growing need for therapeutic strategies to reverse diet-induced weight gain. Read more
Investigation of novel protease-antiprotease imbalances associated with chronic airways disease.
Chronic obstructive pulmonary disease (COPD) is a progressive airways diseases associated with cycles of infection and inflammation, lung tissue destruction and pulmonary decline. Read more
4-year PhD Studentship: Endothelial glycocalyx damage as a therapeutic target in cardiopulmonary bypass associated acute kidney injury
Patients undergoing cardiopulmonary bypass (CPB) often develop acute kidney injury (AKI) caused by myocardial ischemia reperfusion injury (MIRI). Read more
Using novel ferronucleosides to study and regulate DNA replication in cells
Background. Replication of nucleic acid polymers like DNA is an essential process for all known forms of life. Furthermore, dysregulation and errors in DNA-replication are strongly linked with human diseases including cancer, as well as the process of cellular ageing. Read more
Fungal biosynthesis of compounds for enteric methane mitigation
Thirty-five percent of New Zealand’s gross greenhouse gas emissions are a result of methane production in our grazing sheep and cattle. Read more
Fully funded PhD studentship - Misprogramming of mesenchymal progenitor cells in human lung fibrosis
Faculty of Medicine. Main Supervisor. Dr Mark Jones. Other members of the supervisory team. Prof Donna Davies, Dr Yihua Wang, Dr Rob Ewing. Read more
Model-informed development and dose rationale for combination therapy in oncology
The use of combination therapy in oncology, such as checkpoint inhibitor-based immunotherapy has revolutionized the treatment of cancer patients. Read more
Link between inflammation blood clots and the perturbed vessel wall
This project is one of 17 four year PhD Studentships funded by Medical Research Scotland (. https://www.medicalresearchscotland.org.uk. Read more
Validation of TRAF6/PD-L1 inhibition in pre-clinical models of multiple myeloma: implications for combinational immunotherapy
Programmed death-ligand 1(PD-L1), a negative regulator of the immune system, is highly expressed in newly-diagnosed and relapsed multiple myeloma patients, and its expression is associated with suppressed anti-tumour immunity. Read more
The generation of RBCs in vitro from stem cell sources and the molecular regulation of erythropoiesis in health and disease: towards new therapeutic approaches
Development of systems for the generation of red blood cells (RBCs) from stem cell sources (adult peripheral blood, cord blood and induced pluripotent stem… Read more
Investigating the cell biology of Neoparamoeba perurans, a causative agent of Amoebic Gill Disease, and its endosymbiont kinetoplastid, Perkinsela.
Amoebic gill disease (AGD), caused by the opportunistic amoebozoan parasite Neoparamoeba perurans, is a major disease in salmonid aquaculture [1-3] and there is an urgent need to mitigate the impact parasitic infections have on both fish welfare and sustainable growth in the sector. Read more
Investigating the role of autophagy and mitochondrial function in leukaemic stem cells
Our lab is interested in biological processes that contribute to drug resistance in myeloid leukaemias, with particular focus on leukaemic stem cells (LSCs). Read more
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