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insulin PhD Projects, Programmes & Scholarships
We have 15 insulin PhD Projects, Programmes & Scholarships
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Investigating the epigenetic component of insulin secretion disorders. MRC GW4 BioMed DTP PhD studentship 2024/25 Entry, PhD in Clinical and Biomedical Sciences
About the GW4 BioMed2 Doctoral Training Partnership. The partnership brings together the Universities of Bath, Bristol, Cardiff (lead) and Exeter to develop the next generation of biomedical researchers. Read more
Insulin-related intracellular trafficking: role of AGAP2
Insulin is a key hormone regulating glucose metabolism and the intracellular pathways activated by this hormone are still an area of intensive study. . Read more
White Rose BBSRC DTP: Mind over body: the role of astrocytic Hedgehog signalling in mitochondrial dysfunction and insulin resistance
Insulin sensing in the brain regulates metabolic functions including food intake, body weight, energy expenditure, and glucose levels. Read more
How GABA neurones in the DVC control glucose metabolism
The Dorsal Vagal Complex (DVC) of the brain is an important regulator of glucose metabolism and food intake. The Nucleus of the Solitary Tract (NTS) in the DVC senses insulin and triggers a neuronal relay to decrease hepatic glucose production (HPG) in rodents. Read more
The crosstalk between the duodenum and the pancreas: Profiling the immune system to identify the role of the gut in the pathogenesis of type 1 diabetes. MRC GW4 BioMed DTP PhD studentship 2024/25 Entry, PhD in Clinical and Biomedical Sciences
About the GW4 BioMed2 Doctoral Training Partnership. The partnership brings together the Universities of Bath, Bristol, Cardiff (lead) and Exeter to develop the next generation of biomedical researchers. Read more
Interdisciplinary investigation of a large effect of sulfasalazine on HbA1c
The anti-inflammatory drug sulfasalazine, which is used in rheumatoid arthritis and inflammatory bowel disease, was reported earlier to suppress HbA1c in a small cohort of patients [1]. Read more
Metabolic programming: Role of micronutrient (B12) deficiency and associated epigenetic marks
The global epidemic of childhood obesity is a major public health issue. Although current adverse lifestyle (nutrition and physical inactivity) contributes to obesity, a growing body of evidence links early life nutritional adversity to the development of obesity and metabolic disorders in children. Read more
Exploring the relationship between gut microbes, phages, metabolites and cardiometabolic health using computational methods
Metabolomics and the gut microbiome are intricately involved in the risk of metabolic diseases. Read more
Effect of adipokines on placental function in metabolic syndrome
Maternal obesity is associated with increased risk of pregnancy-related cardio-metabolic complications such as gestational diabetes mellitus (GDM) and preeclampsia, that increase the risk of adverse outcomes for both the mother and offspring throughout gestation, labour and even into later life. Read more
Circadian mechanisms in psoriasis: therapeutic opportunities
Hallmark features of psoriasis symptoms vary through time, suggesting an important role for circadian circuits in driving disease expression, and offering the potential of chronotherapy. Read more
Finding the cause for chronic headaches in patients living with acromegaly
Severe headache is a symptom of acromegaly, where patients can manifest the whole range of headache disorders, which cannot be relieved by over-the-counter pain relief. Read more
The role of RNA-binding proteins in determining pancreatic beta-cell fate and diabetes
Endoplasmic reticulum (ER) stress is a significant determinant in the development of type-1 and type-2 diabetes as it has been shown to promote the dysfunction and death of insulin secreting pancreatic beta cells. Read more
Circadian clock control of adipocyte metabolism
Obesity is a major public health issue affecting one third of UK adults, and an estimated 2.1 billion individuals worldwide. The role of circadian clock dysfunction in the development of obesity is becoming clear, with disruptive lifestyles (e.g. Read more
Engineering Biology and its Place in Sensing
One of the key attributes of life is the ability to respond to stimuli. Nature has evolved a wide array of molecules, tissues and organs that sense stimuli as diverse as light, taste, pressure, odour, pheromones, and drugs. Read more
Biological role of neuropeptides and their receptors
Cell signalling is critical to the co-ordination and functioning of all cells. Cell signalling allows cells to co-ordinate activities within the intracellular environment as well as ensuring cells know how to correctly respond to other cells and to an ever-changing extracellular environment as well. Read more
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