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integrin PhD Projects, Programmes & Scholarships

We have 6 integrin PhD Projects, Programmes & Scholarships

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We have 6 integrin PhD Projects, Programmes & Scholarships

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Investigation of antagonism of multiple RGD-binding integrins as a therapeutic strategy in advanced head and neck cancer

  Research Group: Institute of Cancer Therapeutics
Background. The integrins are a family of transmembrane receptors which mediate cell-cell and cell-ECM adhesion, and signalling across the cell membrane involved in pathways controlling cell migration, proliferation, differentiation, cell survival and apoptosis. Read more

SELF-FUNDING MSc BY RESEARCH PROJECT: Underlying mechanism of thrombogenesis in patients with severe coronavirus disease 19 (COVID-19)

Severe coronavirus disease 19 (COVID-19) is a disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). Patients with COVID-19 are at significantly increased risk of thrombosis, which can be a challenge to manage and is associated with elevated mortality and morbidity. Read more

Cancer cells ‘feed’ on extracellular matrix components under starvation conditions: how can they do it?

Background. The tumour microenvironment (TME) has a key role in promoting tumour formation and progression. In breast and pancreatic cancers, this accompanied by the accumulation of extracellular matrix (ECM) in the TME. Read more

Develop single-molecule and super-resolution microscopy imaging technologies in the cardiovascular disease

This project will focus on development, improvement, and application of single-molecule tracking and super-resolution imaging, such as TIRF, HiLo, PALM, STORM, Lattice Light-Sheet Microscopy and other technologies, for the analysis of key proteins in the process of thrombosis and platelet activation, dynamic processes such as molecular conformational changes (i.e. Read more

Cell/extracellular matrix interaction during cell cycle progression: a novel role in controlling nucleotide metabolism?

The deregulation of cell cycle progression is a common feature of cancer formation and progression. Cell/extracellular matrix (ECM) interaction is widely known to support the progression of the cells through the cell cycle. Read more

Cell biology and evolution of cancer metastasis

We are interested in the spread of cancer, a process called metastasis. Metastasis is responsible for the majority of cancer deaths and there are currently no effective treatments to stop this process. Read more
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