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integrin PhD Projects, Programs & Scholarships

We have 7 integrin PhD Projects, Programs & Scholarships

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  The role of tumour microenvironment interactions in melanoma therapy resistance
  Research Group: Institute of Cancer Therapeutics
  Dr H Sheldrake, Dr M Sutherland
Applications accepted all year round
The incidence of malignant melanoma has steadily increased over the past 30 years, and it is predicted that 76,250 new cases will be diagnosed in the US and over 10,000 in the UK this year.
  Mechanistic mathematical / computational modelling of integrin signalling
  Dr N Savage, Dr M Morgan
Applications accepted all year round
Regulation of adhesion dynamics and mechanosensation controls cell migration, microenvironment remodelling and global cell fate decisions.
  Synthesis and Characterisation of Proteolysis targeting chimeras (PROTACs), potential anticancer agents
  Research Group: Institute of Cancer Therapeutics
  Dr H Sheldrake
Applications accepted all year round
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules consisting of a small molecule which binds a desired protein target, a linker, and a ligand which binds to an E3 ubiquitin ligase.
  (BBSCR DTP) Design of allosteric small molecule probes of fibrosis using molecular dynamics simulations
  Dr R A Bryce, Dr K Piper Hanley, Dr R Whitehead
Application Deadline: 31 January 2019
Integrins are a family of protein receptors that play a major role in cell survival, growth and migration. Their function is to transmit signals across the cell membrane by undergoing an elegant large scale structural rearrangement.
  How does fibrillin regulate TGFβ latency and activation?
  Prof C Baldock, Dr A Roseman
Applications accepted all year round
Fibrillin microfibrils are an essential component of our connective tissues and they give tissues such as lung, skin and blood vessels their elasticity.
  Cell biology and evolution of cancer metastasis
  Dr P R Dash
Applications accepted all year round
We are interested in the spread of cancer, a process called metastasis. Metastasis is responsible for the majority of cancer deaths and there are currently no effective treatments to stop this process.
  The molecular mechanisms underpinning individual variation in platelet function and their effect on the progression and treatment of cardiovascular disease.
  Dr CI Jones
Applications accepted all year round
Platelets are small blood cells that play a vital role in the chronic and acute progression of Cardiovascular Disease (CVD). Platelets respond to a range of agonists, which are released when blood vessels are damaged, by aggregating together to form thrombi.
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