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ion channel PhD Projects, Programs & Scholarships

We have 14 ion channel PhD Projects, Programs & Scholarships

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  Ion channel signalling in cancer cells
  Dr W Brackenbury
Application Deadline: 30 June 2020

Funding Type

PhD Type

Our cells constantly sense and transport ions present in their environment. From embryonic development to epilepsy to heart disease to cancer, our cells’ ability to respond to changes in the ionic microenvironment is essential for healthy ageing.
  Molecular Mechanisms of Receptor and Ion Channel Regulation in Pain and Inflammation
  Dr G Cottrell, Dr D Widera, Dr S Amadesi, Dr A McNeish
Applications accepted all year round

Funding Type

PhD Type

"Receptors and ion channels are responsible for the transmission of signals across cellular membranes that regulate a plethora of biological and cellular functions.
  Structural, kinetic and functional characterisation of ion channel function in the gal-3-fibrosome
  Prof B Gooptu, Prof G Vuister
Application Deadline: 7 June 2020

Funding Type

PhD Type

4 Year PhD Studentship available to start September 2020. Fibrosis is a common ageing-associated process that affects all organs.
  Ion channel regulation in models of neurodegeneration
  Dr M Dallas, Prof G J Stephens, Dr A Bithell
Applications accepted all year round

Funding Type

PhD Type

Ion channels are important regulators of cellular physiology. There is now growing awareness that these proteins are invovled in pathological states, with relation to neurodegeneration voltage-gated potassium and voltage-gated calicum channels have been implicated.
  Ion channel clustering in neuronal membranes
  Dr S M Prince, Prof R Ford
Applications accepted all year round

Funding Type

PhD Type

The aim of the study is to investigate the organization of ion channels in the membranes of excitable cells by scaffold proteins, and to discover how the properties of the channels are modified by these interactions.
  Ca2+ signalling in neurodegeneration and Alzheimer’s disease
  Research Group: School of Biology
  Prof I A Hope
Applications accepted all year round

Funding Type

PhD Type

Human variants of the ryanodine receptor, the main intracellular calcium ion channel, could be responsible for Alzheimer’s disease.
  The mechanism of gating and transport of pentameric Magnesium ion channels
  Dr S M Prince, Prof R Ford
Applications accepted all year round

Funding Type

PhD Type

Magnesium ions are a co-factor in many important biological processes particularly because of the requirement for Mg2+ in the hydrolysis of Adenosine tri-phosphate, the ubiquitous cellular energy source.
  Structural insights into ligand binding and channel gating in ATP-gated P2X7 receptor
  Research Group: School of Biomedical Sciences
  Dr L H Jiang, Dr S Muench
Applications accepted all year round

Funding Type

PhD Type

P2X7 receptor, belonging to the ATP-gated ion channel P2X receptor family, exhibits distinct functional and pharmacological properties that are crucial for its role in innate immunity and inflammatory diseases and cancers (Jiang et al., 2013; Caseley et al., 2014; Roger et al., 2014; Wei et al., 2018).
  Targeting mitochondrial dynamics to prevent Parkinson’s disease
  Prof A Sivaprasadarao, Dr R.S. Bon
Application Deadline: 1 June 2020

Funding Type

PhD Type

A common feature of Parkinson’s disease (PD) is the presence of alpha-synuclein protein aggregates in the brains of affected patients.
  Unravelling the dynamics of lipid bilayers and membrane proteins and their reaction to toxins and viral infection on the single molecule level using label-free microscopy.
  Prof W W Langbein, Prof P Borri, Dr MY Young, Dr O Castell
Application Deadline: 5 June 2020

Funding Type

PhD Type

Approximately 30% of the proteins in a cell are membrane proteins, which represent more than 60% of all known drug targets and play a critical role in both infection and immunity.
  Direct characterisation of TRPC channel dynamics triggered by drug-like modulators using high-speed atomic force microscopy
  Research Group: Molecular and Nanoscale Phsyics
  Dr G Heath
Applications accepted all year round

Funding Type

PhD Type

The rapid expansion in the structural understanding of membrane proteins through recent progress in electron microscopy and X-ray crystallography is leading to an ever greater need for techniques which provide high temporal resolution dynamics.
  Molecular Modelling of P2X receptor agonism and antagonism
  Dr R Schmid
Application Deadline: 7 June 2020

Funding Type

PhD Type

P2X receptors (P2XRs) form a family of ligand-gated ion channels activated upon binding of extracellular ATP (for review see [1]).
  Myocardial biology with a specific focus on the mechanisms underlying cardiac fibrosis and atrial fibrillation
  Dr S Reilly, Prof C Redwood, Assoc Prof M Lei
Application Deadline: 24 July 2020

Funding Type

PhD Type

Cardiac fibrosis is a hallmark histological feature of structural changes in the myocardium associated with virtually all cardiac diseases (e.g., heart failure, hypertension, atrial fibrillation and myocarditis).
  Development of Spin based Transistors with 2D Materials
  Research Group: Intelligent Systems and Nanoscience
  Prof Y Xu
Applications accepted all year round

Funding Type

PhD Type

Over the past few decades, size of transistors has been tremendously reduced from a few centimetres to a few tens of nanometres. This trend in down scaling the device size has almost reached its ultimate physical limitation, challenging Moore’s Law which has been valid for almost half a century.
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