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ion channel PhD Projects, Programs & Scholarships

We have 19 ion channel PhD Projects, Programs & Scholarships

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  Ion channel gating kinetics and structure implication for drug delivery
  Research Group: Chemistry and Biosciences
  Dr L Shang, Dr Z Hughes
Applications accepted all year round
Ion channels are proteins which sit in the membrane of every cell in the body and control the flow of positively charged ions such as sodium and potassium into and out of the cell.
  Development and characterisation of synthetic ion channel binding proteins.
  Research Group: School of Biomedical Sciences
  Dr J D Lippiat, Dr D Tomlinson
Applications accepted all year round
We are developing methods to identify novel proteins, Affimers, that recognise extracellular domains of ion channels. These have applications in various aspects of biology, from tools to visualise the location and distribution of ion channels in native tissue, to novel modulators of ion channel function.
  Ion channel regulation in models of neurodegeneration
  Dr M Dallas, Prof G J Stephens, Dr A Bithell
Applications accepted all year round
Ion channels are important regulators of cellular physiology. There is now growing awareness that these proteins are invovled in pathological states, with relation to neurodegeneration voltage-gated potassium and voltage-gated calicum channels have been implicated.
  Ion channel clustering in neuronal membranes
  Dr S M Prince, Prof R Ford
Applications accepted all year round
The aim of the study is to investigate the organization of ion channels in the membranes of excitable cells by scaffold proteins, and to discover how the properties of the channels are modified by these interactions.
  Investigating the mechanism of venom toxins as a potential therapeutic option for acute myeloid leukaemia (AML)
  Research Group: Centre for Cancer Research and Cell Biology
  Prof K Mills, Dr K McCloskey
Application Deadline: 20 January 2019
Acute myeloid leukaemia (AML) is characterised by an excess of immature haematopoietic cells which molecular analysis has identified many acquired genetic mutations and chromosomal translocations.
  Tissue Engineering of Functional Cardiac Tissue using a Newly Characterised Cardiac Stem Cell Population
  Dr R Oldershaw, Dr R Barrett-Jolley, Dr A P Meeson
Applications accepted all year round
We will develop a novel route to create and test stem cell-derived engineered cardiac tissue for use in heart infarct repair or in vitro drug screening.
  The mechanism of gating and transport of pentameric Magnesium ion channels
  Dr S M Prince, Prof R Ford
Applications accepted all year round
Magnesium ions are a co-factor in many important biological processes particularly because of the requirement for Mg2+ in the hydrolysis of Adenosine tri-phosphate, the ubiquitous cellular energy source.
  Electrophysiological changes in ion channels in human haploid and diploid (spermatozoa and lymphocytes) after nanoparticle exposure
  Research Group: Chemistry and Biosciences
  Dr L Shang, Dr M H Brinkworth, Prof D Anderson
Applications accepted all year round
Nanomaterial-mediated delivery represents a promising technique for repro- and geno- toxicology with a potential to improve the safety and efficacy of existing methodologies, including experimental gene therapy and sperm-mediated gene transfer.
  Two pore channel segment 2: a new partner in crime for mTORC1 in pulmonary hypertension
  Prof A M Evans
Applications accepted all year round
Mechanistic target of Rapamycin (mTOR) and regulatory protein of TOR (Raptor) complexes (mTORC1) promote idiopathic- and hypoxic pulmonary hypertension (PH), facilitating pulmonary arterial smooth muscle cell (PASMC) growth, proliferation, and thus pulmonary vascular remodelling.
  Investigation into the molecular function and pain profile of genetic variation in the irritant sensor TRPA1
  Prof A E Pickering
Application Deadline: 31 January 2019
Main Supervisor. Prof. Tony Pickering (University of Bristol). Second supervisors. Dr Jim Dunham (University of Bristol), Dr Laura Addis (Eli Lilly & Co.), Dr Keith Phillips (Eli Lilly & Co.).
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