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ips PhD Projects, Programs & Scholarships

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  Harnessing stem cells to develop regenerative therapies for childhood heart disease.
University of Melbourne Department of Physiology
  Dr E Porrello, Dr D Elliott
Applications accepted all year round
LABORATORY OVERVIEW. The Cardiac Regeneration Laboratory is seeking highly motivated PhD students to work on a project related to understanding the underlying causes of congenital heart disease and developing novel regenerative therapies.
Details
Type/Funding
  Using CRISPR in iPS cells to modify platelet function
University of Reading School of Biological Sciences
  Dr C.E. Hughes
Applications accepted all year round
"Platelets are the small cells in the blood whose job it is to prevent bleeding. Under normal conditions, when they encounter a damaged blood vessel they become activated and form a thrombus.
Details
Type/Funding
  MRC DiMeN Doctoral Training Partnership: How interferon defends the brain against viral invasion
Newcastle University MRC DiMeN Doctoral Training Partnership
  Dr C Duncan, Prof S Hambleton, Dr D Rico, Prof W S James
Application Deadline: 21 January 2019
Contrary to the perception of the brain as an ‘immune-privileged’ organ, it is now clear that the brain engages a potent immune signalling network to defend itself against viral infection (encephalitis).
Details
Type/Funding
  Influence of underlying matrix on induced pluripotent stem cell differentiation and integration of trabecular meshwork cells
University of Liverpool Institute of Ageing and Chronic Disease
  Dr CM Sheridan, Dr R Oldershaw
Applications accepted all year round
There is an urgent need for further treatment options for the blinding condition of Glaucoma Unfortunately with age there is a progressive loss of cells (Trabecular meshwork) from the eye’s outflow pathway which is even more severe with patients with glaucoma.
Details
Type/Funding
  Understanding transcription mediated methylation of intragenic CpG islands in health and disease
University of Leicester Department of Genetics and Genome Biology
  Dr C Tufarelli, Prof S Cowley
Application Deadline: 6 January 2019
1. Project outline describing the scientific rationale of the project (max 4,000 characters incl. spaces and returns). DNA methylation is an epigenetic modification that affects gene expression without altering gene sequences.
Details
Type/Funding
  Understanding Neuroinflammation through advanced in vitro 3D modelling using human Pluripotent Stem Cells
University of Oxford BBSRC Interdisciplinary Bioscience DTP
  Dr S Cowley, Prof W S James
Application Deadline: 25 January 2019
Microglia - brain-resident macrophages - carry out homeostatic surveillance functions in the brain, clearing dying cells, extracellular debris, and pruning synapses during development.
Details
Type/Funding
  The importance of the DNA damage response in neurodegeneration
University of Birmingham Institute of Cancer and Genomic Sciences
  Dr R Tuxworth
Applications accepted all year round
DNA damage occurs in early-stage neurodegenerative diseases. The response of neurons to the damage may contribute to disease progression by inducing senescence, cell-cycle and apoptosis.
Details
Type/Funding
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
University of Cambridge Department of Biochemistry
  Prof E D Laue
Applications accepted all year round
The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
Details
Type/Funding
  4 Year Wellcome Trust PhD Programme: Functions & Applications of a Novel Embryonic Stem Cell Signalling Pathway
University of Dundee School of Life Sciences
  Dr GM Findlay
Application Deadline: 14 December 2018
The Findlay lab employs cutting-edge technologies to unravel Embryonic Stem (ES) cell signalling networks (Williams et al, Cell Rep 2016, Fernandez-Alonso et al, EMBO Rep 2017; Bustos et al, Cell Rep 2018), culminating in our recent discovery of the ERK5 pathway as an exciting new regulator of ES cell pluripotency.
Details
Type/Funding
  MRC DTP 4 Year PhD Programme: Functions & Applications of a Novel Stem Cell Signalling Pathway
University of Dundee School of Life Sciences
  Dr GM Findlay, Dr M Stavridis
Application Deadline: 18 January 2019
This project is part of our exciting and challenging University of Dundee 4-year MRC DTP Programme in Quantitative and Interdisciplinary approaches to biomedical science.
Details
Type/Funding
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