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  Harnessing stem cells to develop regenerative therapies for childhood heart disease.
University of Melbourne Department of Physiology
  Dr E Porrello, Dr D Elliott
Applications accepted all year round
LABORATORY OVERVIEW. The Cardiac Regeneration Laboratory is seeking highly motivated PhD students to work on a project related to understanding the underlying causes of congenital heart disease and developing novel regenerative therapies.
Details
Type/Funding
  Using CRISPR in iPS cells to modify platelet function
University of Reading School of Biological Sciences
  Dr C.E. Hughes
Applications accepted all year round
"Platelets are the small cells in the blood whose job it is to prevent bleeding. Under normal conditions, when they encounter a damaged blood vessel they become activated and form a thrombus.
Details
Type/Funding
  Efficacy testing of biomaterial delivered iPS cells in in vitro cultures systems to mimic the degenerate niche
Sheffield Hallam University Biomolecular Sciences Research Centre
  Prof C Le Maitre, Prof C Sammon
Application Deadline: 31 May 2019
Low back pain (LBP) is a leading cause of disability and morbidity worldwide. It is widely accepted that a major contributor to LBP is intervertebral disc degeneration (IDD).
Details
Type/Funding
  Understanding transcription mediated methylation of intragenic CpG islands in health and disease
University of Leicester Department of Genetics and Genome Biology
  Dr C Tufarelli, Prof S Cowley
Application Deadline: 5 May 2019
1. Project outline describing the scientific rationale of the project (max 4,000 characters incl. spaces and returns). DNA methylation is an epigenetic modification that affects gene expression without altering gene sequences.
Details
Type/Funding
  The importance of the DNA damage response in neurodegeneration
University of Birmingham Institute of Cancer and Genomic Sciences
  Dr R Tuxworth
Applications accepted all year round
DNA damage occurs in early-stage neurodegenerative diseases. The response of neurons to the damage may contribute to disease progression by inducing senescence, cell-cycle and apoptosis.
Details
Type/Funding
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
University of Cambridge Department of Biochemistry
  Prof E D Laue
Applications accepted all year round
The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
Details
Type/Funding
  Chromatin remodelling in health and disease: determining the role of ATRX in the maintenance of chromatin and how mutations perturb disparate nuclear nuclear processes and lead to human disease
University of Oxford Radcliffe Department of Medicine
  Dr R Gibbons, Prof D Higgs
Application Deadline: 26 July 2019
It has become apparent that the regulation of chromatin structure is of paramount importance in a wide variety of fundamental nuclear processes including gene expression, DNA replication, repair and recombination.
Details
Type/Funding
  Genomics of Diabetes: Functional characterisation of T2D GWAS
University of Oxford Radcliffe Department of Medicine
  Dr A Gloyn
Application Deadline: 26 July 2019
Diabetes already affects 415 million people worldwide. In the UK, there will be 5M people with type 2 diabetes (T2D) by 2025, accounting for 1 in 30 prescriptions and £25 billion in annual NHS costs.
Details
Type/Funding
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