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ipsc PhD Projects, Programs & Scholarships
We have 15 ipsc PhD Projects, Programs & Scholarships
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RVC PhD Studentship - Fibrosis: the forgotten villain in feline hypertrophic cardiomyopathy
RVC Supervisor(s). Professor David Connolly. Non RVC Supervisor. Professor Cesare Terracciano. Department. Clinical Science and Services. Read more
Genetics of inherited cardiovascular disease
My group uses molecular genetic analysis of cardiovascular disease as a tool to define disease mechanisms and therapeutic targets. Read more
Elucidating the role of disease modifying gene variants in inherited cardiomyopathies using induced pluripotent stem cell derived cardiomyocytes and CRISPR/Cas-9.
Our group is interested in uncovering and understanding key mechanisms of disease that affect cardiac muscle function. We have a particular interest in understanding how regulation of cardiac muscle contraction is altered in common acquired and inherited cardiovascular diseases. Read more
Understanding the role of impairment in the autophagy-lysosomal pathway in order to develop medications for post-viral neurological dysfunction
Several viruses require interaction with lysosomal proteins or autophagosomes in order to either facilitate infection of the host cell or ensure maturation and release. Read more
PhD: Human stem cell models of de novo tumorigenesis to replace the use of animals for the study of cancer initiation
Human stem cell models of de novo tumorigenesis to replace the use of animals for the study of cancer initiation. A PhD studentship in stem cell biology and disease modelling is available in Dr Allegrucci’s group (. Read more
Last chance to apply
Modelling and making bespoke scaffolds for applications in regenerative medicine
Research Group:
Institute of Quantitative Biology, Biochemistry and Biotechnology
**PLEASE NOTE – the deadline for requesting a funding pack from Darwin Trust has now passed and completed funding applications must be submitted to Darwin Trust by 19th January. Read more
Reverse engineering a human blood-brain barrier platform for studying neurovascular diseases
ABM CDT Dysregulation of the blood-brain barrier (BBB) is an early and critical event in the pathogenesis of neurovascular diseases, such as Alzheimer’s disease, vascular dementia and stroke. Read more
Characterisation of the neuronal receptor for soluble amyloid precursor protein: a route to new therapeutic targets for Alzheimers disease
Alzheimer’s disease (AD) is the commonest form of dementia for which currently there is no means of stopping or even slowing the disease. Read more
Fishing for clues: using zebrafish and human brain organoids to elucidate the pathology of a novel white matter disease
This project is part of a new UK network for research on white matter diseases. LEUKOLABS.UK, a collaboration established by the supervisory team including researchers and clinicians from the Universities of Sheffield, Leeds and York. Read more
An omics approach to understand and treat KMT2C-related neurodevelopmental disorder using induced pluripotent stem cells and CRISPR-Cas9
Background. We recently identified a novel human syndrome caused by mutations in a gene called KMT2C1. Patients with this condition predominantly have developmental delay and intellectual disability indicating the important function of this gene in brain’s normal development and function. Read more
A role for cholesterol metabolism in neurodevelopmental disorder
Microdeletions and duplications of the chromosome 15q11.2 region have been identified as a high penetrant risk copy number variance (CNV) to autism and schizophrenia. CYFIP1 (Cytoplasmic FMR1-interacting protein 1) is generally believed to be the causal risk gene in this CNV. Read more
The generation of RBCs in vitro from stem cell sources and the molecular regulation of erythropoiesis in health and disease: towards new therapeutic approaches
Development of systems for the generation of red blood cells (RBCs) from stem cell sources (adult peripheral blood, cord blood and induced pluripotent stem… Read more
Growth factor isoforms in neural and pancreatic beta cell differentiation
Disorders in which specific cells malfunction and degenerate, such as diabetes and neurodegenerative disease, are a huge unmet health need for which there are currently no curative treatments. Read more
PhD Student Position – Gene Regulation in Stem Cell Biology and Brain Development
A PhD student position is available for highly motivated individuals with an interest in studying stem cell biology and brain development using a combination of molecular, cellular, genetic, and bioinformatics approaches. Read more
Stem Cells: Developing pluripotent stem cell models of inherited retinal diseases
Inherited retinal dystrophies are a leading cause of blindness and visual loss in the UK working age population. However, despite the widespread diagnostic use of next-generation sequencing, a molecular genetic diagnosis is unavailable for many patients world-wide. Read more
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