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ipsc PhD Projects, Programmes & Scholarships
We have 17 ipsc PhD Projects, Programmes & Scholarships
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Do mutation in Sirt6 hold secrets to longevity? Epigenetic mechanisms of patient derived induced pluripotent stem cell (iPSC) differentiation into cardiomyocytes.
Background. Cardiovascular diseases (CVDs) are the leading cause of death globally, taking an estimated 17.9 million lives each year. Read more
Exploring the effect of hypoxia upon glioblastoma progression and response to treatments using a dynamic 3D iPSC-brain organoid
Background. Glioblastoma (GBM) is the most aggressive brain tumour, displaying considerable resistance to drug-/radiation-therapies. Read more
Human iPSC-derived Sensory Neurons to Interrogate the Molecular Interplay between mTORC1 and Histamine H3R in the Progression of Neuropathic Pain
Neuropathic pain is the pain caused by a lesion or disease of the somatosensory system. This system allows for the perception of touch, pressure, pain, temperature and movement. Read more
Mechanistic understanding of how Non-Alcoholic Fatty Liver disease (NAFLD) can lead to cardiovascular dysfunction using induced pluripotent stem cell (iPSC) derived cardiomyocytes and hepatocytes.
Background. Liver disease accounts for 3.5% of all global deaths/year (~2 million people) and is the third leading cause of premature death in the UK with some of the highest hospitalisations in the country seen in areas of socioeconomic deprivation. Read more
Using iPSC-derived neurons and CRISPR-Cas9 to model rare human neurodevelopmental and neuropsychiatric diseases
Research interests/description of main research theme. Applications are invited for a 3-year fully-funded PhD Studentship starting in October 2023 in the laboratory of Dr Martin Higgs at the University of Birmingham. Read more
Investigating the role of endothelial cells in myelin damage in Alzheimer's diseases using iPSC-derived model
Alzheimer’s disease (AD) affects around 50 million people globally with no cure. Apart from well-known neuronal loss, myelin abnormalities in brain have been recently detected from early stage of AD. Read more
Investigating the role of endothelial cells in myelin damage in Alzheimer's disease using iPSC-derived model
Supervisors. Dr. Dan Ma, Lecturer in Biomedical Sciences, Aston Medical School, Aston University. Dr. Irundika Dias, Lecturer in Biomedical Sciences, Aston Medical School, Aston University. Read more
Generating a disease model for Alzheimer's Disease in non-human primates
Our lab is interested in understanding and treating a devastating neurodegenerative disorder, Alzheimer’s Disease (AD), in particular aspects relating to develop appropriate disease models for AD. Read more
Understanding the molecular regulation of epithelial-to-mesenchymal transition (EMT) during heart development: novel targets for cardiac regeneration?
Application consists of completing an online application. To apply, please visit the King’s Apply website at. https://myapplication.kcl.ac.uk/. Read more
Assessing the pathogenesis of pulmonary fibrosis using patient-derived induced pluripotent stem cell models
Background / Overview. Idiopathic pulmonary fibrosis (IPF) is a complex, age-related lung disease that primarily affects people in their 60s and despite advances in research, survival rates remain low. Read more
Investigating the oligogenic model of Amyotrophic Lateral Sclerosis (ALS; motor neuron disease, MND)
Research Group:
Neuroscience
Applications are invited for a multidisciplinary PhD studentship funded by the Motor Neurone Disease Association to study the cumulative contribution of coinherited subthreshold amyotrophic lateral sclerosis (ALS) risk gene variants in the development of cellular hallmarks of ALS pathology. Read more
Fully Funded PhD studentships available for April 2023
We have FULLY FUNDED 3 year PhD studentships available for April 2023 (Home fees and UKRI stipend) within the College of Health & Life Sciences. Read more
Self-funded research projects in the College of Health & Life Sciences
An opportunity for self-funded students to choose one of 30 exciting 3 year projects in the College of Health & Life Sciences. Read more
Stem Cells: Developing pluripotent stem cell models of inherited retinal diseases
Inherited retinal dystrophies are a leading cause of blindness and visual loss in the UK working age population. However, despite the widespread diagnostic use of next-generation sequencing, a molecular genetic diagnosis is unavailable for many patients world-wide. Read more
Growth factor isoforms in neural and pancreatic beta cell differentiation
Disorders in which specific cells malfunction and degenerate, such as diabetes and neurodegenerative disease, are a huge unmet health need for which there are currently no curative treatments. Read more
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