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ipsc PhD Projects, Programs & Scholarships

We have 15 ipsc PhD Projects, Programs & Scholarships

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We have 15 ipsc PhD Projects, Programs & Scholarships

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Elucidating the role of disease modifying gene variants in inherited cardiomyopathies using induced pluripotent stem cell derived cardiomyocytes and CRISPR/Cas-9.

Our group is interested in uncovering and understanding key mechanisms of disease that affect cardiac muscle function. We have a particular interest in understanding how regulation of cardiac muscle contraction is altered in common acquired and inherited cardiovascular diseases. Read more
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Modelling and making bespoke scaffolds for applications in regenerative medicine

  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
**PLEASE NOTE – the deadline for requesting a funding pack from Darwin Trust has now passed and completed funding applications must be submitted to Darwin Trust by 19th January. Read more

Reverse engineering a human blood-brain barrier platform for studying neurovascular diseases

ABM CDT Dysregulation of the blood-brain barrier (BBB) is an early and critical event in the pathogenesis of neurovascular diseases, such as Alzheimer’s disease, vascular dementia and stroke. Read more

An omics approach to understand and treat KMT2C-related neurodevelopmental disorder using induced pluripotent stem cells and CRISPR-Cas9

Background. We recently identified a novel human syndrome caused by mutations in a gene called KMT2C1. Patients with this condition predominantly have developmental delay and intellectual disability indicating the important function of this gene in brain’s normal development and function. Read more

A role for cholesterol metabolism in neurodevelopmental disorder

Microdeletions and duplications of the chromosome 15q11.2 region have been identified as a high penetrant risk copy number variance (CNV) to autism and schizophrenia. CYFIP1 (Cytoplasmic FMR1-interacting protein 1) is generally believed to be the causal risk gene in this CNV. Read more

Growth factor isoforms in neural and pancreatic beta cell differentiation

Disorders in which specific cells malfunction and degenerate, such as diabetes and neurodegenerative disease, are a huge unmet health need for which there are currently no curative treatments. Read more

PhD Student Position – Gene Regulation in Stem Cell Biology and Brain Development

A PhD student position is available for highly motivated individuals with an interest in studying stem cell biology and brain development using a combination of molecular, cellular, genetic, and bioinformatics approaches. Read more

Stem Cells: Developing pluripotent stem cell models of inherited retinal diseases

Inherited retinal dystrophies are a leading cause of blindness and visual loss in the UK working age population. However, despite the widespread diagnostic use of next-generation sequencing, a molecular genetic diagnosis is unavailable for many patients world-wide. Read more
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