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We have 28 kinase PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
kinase PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 28 kinase PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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MSc by Research: Non-canonical functions of SRSF protein kinase (SRPK) in pluripotent stem cells
The overarching goal of our research is to identify and characterise the protein kinase signalling pathways that control stem cell pluripotency and differentiation and determine how protein kinase signalling is disrupted to cause human developmental disorders. . Read more
Role of PAS-domain coantaining protein kinase in the regulation of feeding behaviour
In this project, we will probe the role of the energy sensing protein kinase, PAS-domain protein kinase (PASK) in energy sensing in the ventromedial hypothalamus (VMH). Read more
MSc by Research: Monitoring and manipulating kinase activity in stem cells
Posttranslational modifications of proteins are important regulatory events that impact most if not all physiological functions of cells. Read more
The functions of the Class II Pi3-kinase signals in vivo
Phosphoinositide lipids (PIPs) play critical roles in development and the homeostasis of adult tissues and their dysfunction has been linked to major human diseases such as cancer, diabetes, myopathies and neuropathies. Read more
Is there a Role for Activated Akt in Palatogenesis?
Main Aim. The project will use a medial edge epithelial (MEE) cell line as an in vitro model. These cells will be used to investigate the effects of exogenous TGFβ-3 and activation of Akt on cell migration, epithelial to mesenchymal transition (EMT) and apoptosis. Read more
MSc by Research: Deciphering underlying pathways and impact on LRRK2 signalling network in hereditary Parkinson’s disease
Parkinson’s disease (PD) is a common neurodegenerative condition with no cure and complex aetiology. Around 5-10% a PD cases can be attributed to a monogenetic cause, including LRRK2, while for another ~ 10% of familial cases, the underlying genetic causes have yet to be identified. Read more
MSc by Research: Does CDK1 regulate NICD turnover in a cell cycle dependant manner in Drosophila Melanogaster?
Notch is one of the major highly conserved signalling pathways that regulate cell-cell communication which involves gene regulation mechanisms that control multiple processes during development and adult life, including cell fate specification within progenitors. Read more
Mechanisms of primary cilia formation
The primary cilium is an enigmatic, antenna-like organelle present on the surface of most cells. Whilst it was originally described as a vestigial organelle, recent years have indisputably proven its status as a seminal structure for sensing various extracellular stimuli. Read more
FGFR signalling in cancer
Growth factors are used during development to convey messages that tell cells to divide, survive, migrate, and adopt a particular fate. Read more
MSc By Research: Time and space of cell growth regulation
Keywords. Cell biology, Biochemistry, Signalling pathway. Background. Cell growth is dynamically regulated in response to external cues such as nutrient availability, growth factor signals, and stresses. Read more
Identification of mechanisms underlying atrial fibrillation and effective therapies
Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice with particular high prevalence in aged populations. Read more
Basal stem cells in the lung and their recognition of dying cells
Stem cell division and differentiation is critical for barrier repair following inflammation, but the initial trigger for this process is unknown. Read more
Effect of vitamin D in vascular and endocrine cells
Vitamin D3 deficiency is a common public health problem worldwide that is increasingly believed to contribute not only to decreased bone mineralisation but potentially to other serious medical conditions. Read more
Metabolic reprogramming in cancer: starving tumors of essential nutrients to promote cell death
All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow. Read more
Bifunctional small molecules beyond PROTACs: Proximity-inducing new downstream chemistries to rewire cell signalling
Proteolysis targeting chimeras (PROTACs) are a popular class of bifunctional molecules that simultaneously engage a target protein on one end and an E3 ubiquitin ligase on the other end, forming a ternary complex that facilitates the rapid ubiquitylation and subsequent degradation of the target protein. Read more
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