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kinase PhD Projects, Programs & Scholarships

We have 43 kinase PhD Projects, Programs & Scholarships

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  (BBSRC DTP) Developing new computer-based technologies for designing protein kinase inhibitors by quantifying peptide-protein binding.
  Dr A Almond, Dr A Golovanov
Application Deadline: 31 January 2019
This PhD studentship will apply computational and mathematical techniques to one the most fundamental, important and complex of biological problems – that of protein-protein interactions.
  Elucidating the protein interaction network of serum- and glucocorticoid-regulated kinase 1 (SGK1)
  Dr K Brown
Applications accepted all year round
The phosphoinositide 3-kinase (PI3K) pathway is a master regulator of numerous cellular phenotypes associated with cancer including cell survival, proliferation, growth, altered metabolism and malignant transformation.
  Cardiac energetics and integrative physiology: Studying key components of the creatine kinase system to understand how they contribute to the pathophysiology of ischaemic heart disease and chronic heart failure.
  Prof C Lygate, Dr S Zervou
Application Deadline: 26 July 2019
Studying key components of the creatine kinase system to understand how they contribute to the pathophysiology of ischaemic heart disease and chronic heart failure.
  Molecular role of Bruton's Tyrosine Kinase (BTK) in the NLRP3 Inflammasome
  Prof A Weber
Application Deadline: 30 January 2019
Topic. The NLRP3 inflammasome is a multi-protein complex driving inflammation upon exogenous and endogenous (sterile) insults during infection, tissue damage or cellular stress and its assembly has been considered a key process in initiating inflammation.
  The role of hnRNPUL proteins in the DNA damage response.
  Dr R J A Grand, Dr G Stewart
Applications accepted all year round
Applications Open to. Someone who is very highly committed to scientific research with a 2.1 or equivalent degree in a science subject and can provide their own funding.
  Cardiotoxicity of cancer drugs targeting the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade
  Prof A Clerk
Applications accepted all year round
"Heart failure is a leading cause of morbidity and mortality worldwide. The contractile cells of the heart, cardiomyocytes, possess many protective mechanisms, allowing them to withstand pathophysiological stresses.
  Structure guided inhibitors design of human Mitochondrial Thymidine Kinase (TK2)
  Dr Y Jin
Application Deadline: 15 March 2019
Background. Mitochondrial Thymidine Kinase 2 (TK2) catalyses transfer of a γ-phosphate group from ATP to the 5′-hydroxyl group of thymidine, deoxycytidine, or deoxyuridine to form their 5’-mono-phosphates.
  Characterization of cyclin-dependent kinase 12 (CDK12) substrates and their roles in regulation of transcription and tumorigenesis
  Dr D Blažek, Prof Z Zdrahal
Application Deadline: 3 February 2019
Cdk12 is transcriptional cyclin-dependent kinase (Cdk) found mutated in various cancers. In previous studies we found that Cdk12 maintains genome stability via optimal transcription of key homologous recombination repair pathway genes including BRCA1.
  Functions of cyclin-dependent kinase 11 (CDK11) in regulation of gene expression
  Dr D Blažek, Assoc Prof Z Zdráhal, Dr P Alexiou
Application Deadline: 15 March 2019
CDK11 is ubiquitously expressed in all tissues and the CDK11 null mouse is lethal at an early stage of development indicating an important role for Cdk11 in the adult as well as during development.
  (BBSRC DTP) Inhibition of SR protein kinase 1 with designer peptides
  Dr A Golovanov, Dr A Almond
Application Deadline: 31 January 2019
This PhD project addresses BBSRC’s ENWW in that the student will be trained in. Biophysical techniques - ITC, SPR, CD; Structural biology techniques - solution state NMR and X-ray crystallography; Computational techniques - molecular dynamics simulations and computer modelling and analysis.
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