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kinase PhD Projects, Programs & Scholarships

We have 37 kinase PhD Projects, Programs & Scholarships

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  Probing Conformational Change in Protein Kinases Using Single Molecule Fluorescence Spectroscopy and Unnatural Amino Acids
  Dr C Dodson, Dr I M Eggleston
Applications accepted all year round

Funding Type

PhD Type

This project will be a collaboration between Dr Charlotte Dodson (lead), Department of Pharmacy & Pharmacology, University of Bath;.
  Using single molecule spectroscopy to determine the drivers of conformational change in protein kinases
  Dr C Dodson
Applications accepted all year round

Funding Type

PhD Type

Protein kinases are central to many cellular processes (eg cell division and the response to external signals) and are current drug targets in cancer, cardiac and inflammatory disease.
  Unravelling the oncogenic activities of serum- and glucocorticoid-regulated kinase 1 (SGK1)
  Dr K Brown
Applications accepted all year round

Funding Type

PhD Type

The phosphoinositide 3-kinase (PI3K) pathway is a master regulator of numerous cellular phenotypes associated with cancer including cell survival, proliferation, growth, altered metabolism and malignant transformation.
  Mechanisms of regulation of the phosphoinositide 3-kinase family of enzymes
  Dr R Williams
Application Deadline: 3 December 2019

Funding Type

PhD Type

Our research programme aims at establishing mechanisms of regulation of an ancient family of giant kinases involved in cellular homeostasis.
  Cardiotoxicity of cancer drugs targeting the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade
  Prof A Clerk
Applications accepted all year round

Funding Type

PhD Type

"Heart failure is a leading cause of morbidity and mortality worldwide. The contractile cells of the heart, cardiomyocytes, possess many protective mechanisms, allowing them to withstand pathophysiological stresses.
  Characterization of cyclin-dependent kinase 12 (CDK12) substrates and their roles in regulation of transcription and tumorigenesis
  Dr D Blažek, Prof Z Zdrahal
Application Deadline: 31 October 2019

Funding Type

PhD Type

Cdk12 is transcriptional cyclin-dependent kinase (Cdk) found mutated in various cancers. In previous studies we found that Cdk12 maintains genome stability via optimal transcription of key homologous recombination repair pathway genes including BRCA1.
  Functions of cyclin-dependent kinase 11 (CDK11) in regulation of gene expression
  Dr D Blažek, Assoc Prof Z Zdráhal, Dr P Alexiou
Application Deadline: 31 October 2019

Funding Type

PhD Type

CDK11 is ubiquitously expressed in all tissues and the CDK11 null mouse is lethal at an early stage of development indicating an important role for Cdk11 in the adult as well as during development.
  Functional and structural characterization of a putative atypical kinase in Mycobacteria
  Dr B Tefsen, Dr D Ruiz, Dr M Horsburgh
Applications accepted all year round

Funding Type

PhD Type

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a major burden for global healthcare. Increasing multi-drug resistance in Mtb makes treatment of TB harder every year.
  The functions of the Class II Pi3-kinase signals in vivo
  Dr L MacDougall, Dr M Baron
Applications accepted all year round

Funding Type

PhD Type

Phosphoinositide lipids (PIPs) play critical roles in development and the homeostasis of adult tissues and their dysfunction has been linked to major human diseases such as cancer, diabetes, myopathies and neuropathies.
  Polo-like kinase inhibitors for targeted therapy in adrenocortical carcinoma
  Dr C L Ronchi, Dr P Foster
Applications accepted all year round

Funding Type

PhD Type

Adrenocortical carcinoma (ACC) is a rare cancer with a generally poor prognosis and partially unknown pathogenesis.
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