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leukaemia PhD Projects, Programmes & Scholarships
We have 24 leukaemia PhD Projects, Programmes & Scholarships
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Exploiting metabolic vulnerabilities induced by dietary restriction as novel therapies for infant leukaemia
TO APPLY, CLICK 'INSTITUTION WEBSITE'. Infant leukaemia is an aggressive malignancy with cure rates of less than 50%. Importantly, despite large international trials, there has been no improvement in survival over the last 2 decades. Read more
Investigating the role of the microenvironment in paediatric and adult acute myeloid leukaemia
The incidence of acute myeloid leukaemia (AML) increases with age, and in childhood accounts for 20% of all leukaemia. The current overall survival rate in children is only 60-70%, and thereafter falls progressively with age to 5-15% in the elderly. Read more
Gene correlation network showing differences in gene expression of effector T cells derived from the bone marrow or peripheral tissues affected by GVHD.
Our group is interested in developing novel immunotherapeutic approaches for leukaemia. Clinical approaches currently used include allogeneic haematopoietic stem cell transplantation, chimeric antigen receptor T cell therapy and immune checkpoint inhibitors. Read more
Gene correlation network showing differences in gene expression of effector T cells derived from the bone marrow or peripheral tissues affected by GVHD.
Our group is interested in developing novel immunotherapeutic approaches for leukaemia. Clinical approaches currently used include allogeneic haematopoietic stem cell transplantation, chimeric antigen receptor T cell therapy and immune checkpoint inhibitors. Read more
Evaluation of combination therapies targeting DNA damage repair signalling pathways in acute myeloid leukaemia
Acute myeloid leukaemia (AML) is an aggressive cancer affecting mostly adult and elderly patients. It has a very poor 5-year survival of <20% in the UK. Read more
The role of PHF6 during haematopoietic differentiation
PHD finger protein 6 (PHF6) is a protein, consisting of two atypical plant homeodomains (aPHD1/2) with nuclear and nucleolar localization sequences. Read more
Institute of Cancer Sciences
The Institute of Cancer Sciences is part of a national centre of excellence in the fight against cancer. We carry out a programme of world-class science directed at understanding the molecular changes that cause cancer. Read more
Transcription factor complexes in Acute Myeloid Leukaemia
Acute Myeloid Leukaemia (AML) is a group of blood cancers, resulting from uncontrolled cellular proliferation of cells belonging to the myeloid lineage. Read more
Single Cell Biology of Hematopoietic Stem- and Progenitor Cells in Blood Cancer and Ageing
The focus of the Nerlov laboratory is combining single cell biology (single cell RNAseq, ATACseq and functional analysis) with advanced mouse genetics to study hematopoietic stem– and progenitor cells in normal development and during ageing. Read more
Single Cell Biology of Hematopoietic Stem- and Progenitor Cells in Blood Cancer and Ageing
The focus of the Nerlov laboratory is combining single cell biology (single cell RNAseq, ATACseq and functional analysis) with advanced mouse genetics to study hematopoietic stem– and progenitor cells in normal development and during ageing. Read more
4-year PhD Studentship: The bone marrow-derived stromal cells – a therapeutic target in haematological malignancy
Bone marrow consists of blood stem cells known as haematopoietic stem cells (HSC) embedded in a matrix of diverse cell populations referred to as the bone microenvironment or ‘niche’. Read more
Normal and leukaemic stem/progenitor cell biology and immune responses to blood cancer cells.
Blood cell differentiation is one of the best characterised models to study how normal tissue-specific stem cells give rise to diverse cell types. Read more
Normal and leukaemic stem/progenitor cell biology and immune responses to blood cancer cells.
Blood cell differentiation is one of the best characterised models to study how normal tissue-specific stem cells give rise to diverse cell types. Read more
Macrophage driven therapy resistance in AML: from macrophage subset characterisation to therapeutic targeting.
Research Group:
Molecular Mechanisms and Long Term Conditions
Reference. SHLS20065. Background. Acute Myeloid Leukaemia (AML) is a common blood cancer in adults; with its incidence increasing with age, AML cases are predicted to double by 2030. Read more
Investigating the role of autophagy and mitochondrial function in leukaemic stem cells
Our lab is interested in biological processes that contribute to drug resistance in myeloid leukaemias, with particular focus on leukaemic stem cells (LSCs). Read more
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