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lungs PhD Projects, Programmes & Scholarships
We have 26 lungs PhD Projects, Programmes & Scholarships
How do bacteria adapt survive in the lungs of patients with chronic lung infections like bronchiectasis?
Haemophilus influenzae and Pseudomonas aeruginosa are key pathogens in bronchiectasis and other chronic lung diseases like COPD. Chronic infections are associated with decreased quality of life and increased disease severity in patients and antibiotic treatments often fail to clear infections. Read more
Development of lung in vitro model to assess antimicrobial activity
When developing new inhaled antibiotics to treat lung infections, they will need to be tested before being given to humans. Current methods to test inhaled antibiotics are based on animals which are both inhumane and lack efficacy. Read more
Using innovative microfluid technology to study infection dynamics in human lungs
Lung infections and diseases pose significant challenges to global health, impacting millions of individuals worldwide. Aspergillus, Cryptococcus, Pneumocystis, and endemic fungi are major pulmonary fungal pathogens that can result in life-threatening invasive diseases in immuno-compromised patients. Read more
Impact of the alarmin Il-33 on neutrophilic inflammation in chronic lung disease
Blockade of the epithelial alarmin IL-33 is a novel treatment strategy in development for people with asthma, COPD and other chronic lung conditions like bronchiectasis. Read more
Resident memory B cell responses in the lung; immunity against pulmonary pathogens
Immunological memory of antibody responses is critical for the ability of the host to cope with secondary infections and is the basis for the development of most current vaccines. Read more
Functional effects of variable number tandem repeat expansions in idiopathic pulmonary fibrosis
Research Group:
Human & Medical Genetics
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease characterized by the formation of scar tissue in the lungs. Read more
Selective targeting of furin for the treatment of fibrotic lung disease.
Furin, a proprotein convertase has been established as a therapeutic target across several disease areas to include chronic airways diseases and infectious disease, such as COVID-19 (reviewed in our recent publication, Douglas et al, 2023). Read more
Investigating the cardio-pulmonary impact of airborne nanoplastics
There is growing evidence that humans are exposed to incidental microplastics and nanoplastics (MNPL) particles through inhalation and that the small size of these particles may allow for bioaccumulation and retention in the body. Read more
Nanoparticle delivery of antibiotics for treatment of pulmonary infection
Antimicrobial resistance (AMR) poses a major global risk to human health by causing death, disability, longer hospitalisations, and increased healthcare costs. Read more
(BRC) Investigating neutrophil activation and altered epithelial structure in chronic obstructive pulmonary disease
The National Institute of Health and Care Research (NIHR) funds Biomedical Research Centres (BRCs) as experimental medicine centres of excellence via competitive application every five years. Read more
(MRC DTP) Exploring steroid chronotherapy in allergic airways disease
Asthma is a common, inflammatory disease of the airways. The cornerstone of treatment for asthma is long term inhaled corticosteroids (ICS) with systemic corticosteroids for exacerbations. Read more
(MRC DTP) Unravelling the tissue signals controlling immune memory formation during nematode infections
Complex multicellular organisms evolved to ensure that each tissue or organ responds appropriately to challenge with an infectious agent. Read more
(MRC DTP) Identifying cellular and molecular mechanisms during coinfection with respiratory pathogens
Aspergillus fumigatus (Af), a critical human fungal pathogen according to the WHO, annually causes >20 million pulmonary infections with four million having life threatening disease. Read more
(MRC DTP) Identifying the molecular interactions that drive mucosal responses to the fungal pathogen Aspergillus fumigatus
Spores of the mould Aspergillus fumigatus cause >3,000,000 chronic and >300,000 invasive diseases annually worldwide. Invasive aspergillosis is the most fatal, with a 50% mortality rate. Read more
Identifying the molecular interactions that drive mucosal responses to the fungal pathogen Aspergillus fumigatus
Spores of the mould Aspergillus fumigatus cause >3,000,000 chronic and >300,000 invasive diseases annually worldwide. Invasive aspergillosis is the most fatal, with a 50% mortality rate. Read more
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