Background. A hallmark of cancer is aberrant cell cycle control leading to pathological cell proliferation. Cell cycle progression is controlled by key kinases, such as cyclin-dependent kinases (CDKs) and polo-like kinases (PLKs).
This is collaborative project between King’s Chemistry (Politis Lab) and OMass Therapeutics (Oxford). The primary aim of the project is to explore how lipids impact on the structure, dynamics and function of human integral membrane protein assemblies.