This is collaborative project between King’s Chemistry (Politis Lab) and OMass Therapeutics (Oxford). The primary aim of the project is to explore how lipids impact on the structure, dynamics and function of human integral membrane protein assemblies.
Background. A hallmark of cancer is aberrant cell cycle control leading to pathological cell proliferation. Cell cycle progression is controlled by key kinases, such as cyclin-dependent kinases (CDKs) and polo-like kinases (PLKs).
Campylobacter jejuni is the major causative agent of foodborne gastroenteritis across Europe. Contaminated chicken meat is the main source of infections and hence control of this pathogen is critical to food security in the poultry industry.