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mechanism PhD Projects, Programmes & Scholarships
We have 319 mechanism PhD Projects, Programmes & Scholarships
MSc by Research: Sugar ubiquitylation, a new quality control mechanism for the recognition and elimination of unbranched glycogen?
The accumulation and precipitation of unbranched glycogen in human tissues as toxic polyglucosan bodies (PB) underlies four human diseases that cause cardiomyopathy and heart failure and/or fatal neurological disorders. Read more
Deciphering the non-homologous end joining (NHEJ) DNA-double strand break repair mechanism in Mycobacterium tuberculosis
In all kingdoms of life, DNA damaging agents can jeopardize the integrity of the cellular genome, resulting in a range of developmental defects. Read more
The mechanism of the therapeutic potential of stem cell-derived Dendrobium Officinale sprouts (DOS) for gastric mucosa wound healing
Dendrobium Officinale (DO) is a traditional Chinese medicine for repairing gastrointestinal mucosa injuries. Plant stem cell-derived DO sprouts (SDO) exhibits more significant mucosa wound-healing effects than DO. Read more
MSc by Research: Unravelling the molecular mechanism underpinning Ubiquitin-like fusion protein proteolysis
The Maniaci Lab tackles one of the big puzzles in cell biology. How can cells create a vast diversity of proteins from a limited genetic blueprint? This diversity is essential for life and is largely achieved through post-translational modifications (PTMs) – molecular “tags” added to proteins after they’re made. Read more
The Mechanism of Ammonia Accumulation-Induced Suppression on Urea Cycle Enzymes via Activating HIF Proteins
This research proposal aims to investigate the mechanism by which ammonia accumulation suppresses urea cycle enzymes through the activation of hypoxia-inducible factor (HIF) proteins. Read more
Investigate the molecular mechanism controlling FEME (Fast Endophilin Mediated Endocytosis) in directed cancer cell migration using CRISPR, biochemistry, and advanced microscopy methods.
Cancer is a devastating disease. more than one in three people in the UK will develop cancer in their lifetime. Metastasis is the primary cause of cancer related deaths. Read more
Novel flexibility mechanism for local energy markets and techno-economic framework for coordinated procurement of distributed flexibility in electricity distribution systems
Advances in low-carbon technologies trigger the evolution of electricity grids from passive networks to active systems, characterized by flexible networks, controllable loads and dispatchable generators. Read more
Investigation of white etching crack damage mechanism in wind turbine gearbox bearings
Modern wind turbine gearbox bearings are failing prematurely, by white structure flaking and axial cracking, which may be caused by the propagation of subsurface white etching cracks (WECs). Read more
Redefining DNA-double strand break repair in humans
Numerous DNA damaging agents constantly cause damage to cellular DNA. Read more
York YBDTP project: Elucidating the Mechanism of Hypoxic Reprogramming of the Estrogen Response.
Lead supervisor: Dr AN Holding. Co-supervisors: Dr William J Brackenbury. The student will be registered with the Department of Biology (University of York). Read more
Elucidating the Mechanism of Hypoxic Reprogramming of the Estrogen Response.
The Estrogen Receptor (ER) plays a central role in breast development, and when it goes wrong, in disease. A key question in tissue development is what causes different cells to show a coordinated response to the molecular messages and how is this regulation maintained. Read more
Last chance to apply
(BBSRC NWD) Investigating the mechanism of cell signalling by cytonemes in Drosophila ovarian germline stem cells
Cell signalling is essential to multicellular life and its misregulation causes a vast number of human diseases, including cancer and cardiovascular disorders. … Read more
[FSE Bicentenary PhD] From Nature to Mechanism: Optimizing Soft Robot Deformations via Neural Rendering Base Self-Modelling
This research investigates biomimicry-inspired kinematics in soft robotics through neural field based rendering pipelines, leveraging the existing differentiable simulation framework for soft robot kinematics developed in the Digital Manufacturing Lab at the University of Manchester. Read more
Draw down of volcanic CO2 as a mechanism of climate recovery following periods of enhanced volcanism in Earth’s geological past
Large igneous provinces (LIPs) have been linked with major disruptions of Earth’s climate system. These include four of the five major mass extinctions of the Phanerozoic and widespread episodes of environmental change during Ocean Anoxic Events (OAE). Read more
Last chance to apply
Molecular Mechanism for Initiation of DNA Replication in Bacteria
Primary Supervisor: Dr Aravinda Ilangovan. Co-Supervisor(s): Dr Vladimir Volkov. Funding: China Scholarship Council (CSC). Read more