MRC Mitochondrial Biology Unit. The key objective of this PhD project is to study nuclear-encoded proteins involved in mitochondrial (mt-) RNA metabolism, in order to understand how their dysfunction is linked to human mitochondrial pathologies.
Complex I (NADH:ubiquinone oxidoreductase) catalyses the first step in the respiratory chain and oxidative phosphorylation. NADH oxidation and quinone reduction, coupled to proton translocation across the inner membrane.
The Industrial Doctorate Centre (IDC) in Machining Science is a unique collaboration between industry, the University of Sheffield's Advanced Manufacturing Research Centre (AMRC) and the Faculty of Engineering.
The Engineering and Physical Sciences Research Council (EPSRC) is the main UK government agency for funding research and training in engineering and the physical sciences, investing more than £850m a year, http://www.epsrc.ac.uk.