Background. A long-standing fundamental challenge in cross-coupling chemistry is the formation of stereodefined carbon-carbon bonds using Csp3-Csp2 Suzuki-Miyaura cross-coupling. Read more
Background. Fragment-based methods are established for the identification of lead compounds in drug discovery.[1] Fragments are small molecules (molecular weight ~150-300) which bind weakly to proteins. Read more
Nucleoside analogues (NAs) are an important class of antiviral and anticancer agents commonly used in the therapy of many different viral infections and cancer conditions. Read more
Research Group:
Astbury Centre for Structural Molecular Biology
Antibiotics make possible the treatment and cure of life-threatening bacterial infections and have added over a decade to average human lifespan. Read more
Summary. Macrocycles (12+ membered rings) and medium-sized rings (8–11-membered) are cyclic molecules with great potential in many scientific fields and technologies – especially in medicinal chemistry. Read more
Background. Coronaviruses (CoVs) are important human pathogens and SARS-CoV-2 is responsible for the COVID-19 pandemic. Notwithstanding progress in available vaccines for COVID-19, there remains a need to develop small molecule drug candidates for treating COVID-19. Read more
Research project. We are seeking a highly motivated PhD candidate to join an interdisciplinary team at the University of Otago, to undertake research developing chemical probes for the cannabinoid receptor, a type of G protein-coupled receptor (GPCR). Read more
We are seeking strongly motivated and competitive candidates to conduct PhD research as part of an internationally-recognised research team involved in drug discovery and chemical probe design based on the element boron. Read more
Discover the art of developing life-changing pharmaceuticals through our Medicinal Chemistry program. The aim of this programme is to prepare qualified experts who will work professionally in scientific activities in the field of development and analysis of drugs and its application to other scientific fields. Read more
Saarland University (UdS) is located in the Saarbrücken, Germany. The city is a state capital with 180.000 inhabitants, located between and well connected to Frankfurt, Paris, and Luxembourg. Read more
Background. Oligonucleotide (ON) therapeutics is an exciting clinically approved platform for the treatment of a range of diseases not readily accessible by small molecule drugs. Read more
Platelets (small circulating blood cells) are involved in blood clotting to prevent excessive bleeding, however, their inappropriate activation under pathological conditions leads to thrombosis resulting in major cardiovascular diseases such as heart attack and stroke. Read more
In the UK alone, neurodegenerative diseases will affect 2 million people by 2051, have very limited effective treatments and cost the economy £26.3Bn annually. Read more
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