Masaryk University
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medicinal chemistry PhD Projects, Programmes & Scholarships
We have 52 medicinal chemistry PhD Projects, Programmes & Scholarships
We have 52 medicinal chemistry PhD Projects, Programmes & Scholarships
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Two PhD Fellowships in Organic Synthesis and Medicinal Chemistry
Two PhD Fellowships in Organic Synthesis and Medicinal Chemistry. Workplace. Laboratory of Organic Synthesis and Medicinal Chemistry, Department of Chemistry, Faculty of Science, Masaryk University in Brno, Czech Republic. Read more
Medicinal Chemistry Project: Synthesis of novel small molecules for the potential treatment of the asbestos induced lung cancer mesothelioma
The Project. In developing a new therapeutic agent, there are two questions to address. how to get the potential drug to the specific site in the body where it is needed and second, does it do what we want it to do at the target site and without undesirable side effects. Read more
PhD in Chemistry: Medicinal Chemistry of Nucleotide Analogues
Nucleoside analogues (NAs) are an important class of antiviral and anticancer agents commonly used in the therapy of many different viral infections and cancer conditions. Read more
Fragment-Based Lead Generation of Small Molecule Inhibitors of the Nsp3 Macrodomain in SARS-CoV-2 – Towards New Antivirals for the Treatment of COVID-19
Fragment-Based Lead Generation of Small Molecule Inhibitors of the Nsp3 Macrodomain in SARS-CoV-2 – Towards New Antivirals for the Treatment of COVID-19. Read more
Medicinal Chemistry project, Faculty of Medical Sciences
The threat to human health due to the emergence of antibiotic-resistant microorganisms is estimated to reach 10 million deaths per year by 2050 according to a recent report from the . Read more
Self Funded BMS Project: Fragment-Based Lead Generation of Small Molecule Inhibitors of the Nsp3 Macrodomain in SARS-CoV-2 – Towards New Antivirals for the Treatment of COVID-19
Applications accepted for PhD Only. Background. Coronaviruses (CoVs) are important human pathogens and SARS-CoV-2 is responsible for the current COVID-19 pandemic (>260m cases, 5.2m deaths). Read more
Modular Synthetic Platform for the Optimisation of Fragment Hits Using Bifunctional 3-D Building Blocks
Modular Synthetic Platform for the Optimisation of Fragment Hits Using Bifunctional 3-D Building Blocks. Supervisor. Peter O’Brien. Read more
Stereospecific Csp3-Csp2 Cross-Coupling of Saturated Heterocyclic Boronates
Stereospecific Csp3-Csp2 Cross-Coupling of Saturated Heterocyclic Boronates. Main supervisor. Peter O’Brien. Co-supervisor. Ian J S Fairlamb. Read more
Design and synthesis of chemical tools to interrogate G protein-coupled receptors
Research project. We are seeking a highly motivated PhD candidate to join an interdisciplinary team at the University of Otago, to undertake research developing chemical probes for G protein-coupled receptors (GPCRs). Read more
Development of Positive Allosteric Modulators of P2X4 for the Treatment of Multiple Sclerosis
Development of Positive Allosteric Modulators of P2X4 for the Treatment of Multiple Sclerosis. The Project. Multiple sclerosis (MS) affects millions of people world-wide. Read more
Neuropeptide Research – PhD Position at a World Class Institution
Neuropeptides are key mediators in many biological functions and understanding their interaction with target proteins is fundamental to unravel the underlying mechanism of diseases. Read more
Development of antiviral peptidomimetic enzyme inhibitors against SARS-CoV-2
Coronaviruses are a large group of viruses that circulate and evolve among various animals. They can cause mild human illnesses such as the common cold or more serious respiratory diseases as seen in the recent outbreaks of SARS (2002), MERS (2012), and the COVID-19 pandemic (2019). Read more
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An approach to synthetic oligonucleotide aptamers with modified properties (SEARCEYM_USCIPVC)
In the development of new drugs for the treatment of cancer, targeting of specific pathways is a key element of design. Non-targeted agents, the classical chemotherapeutics such as cisplatin and doxorubicin, have off target effects that lead to debilitating side effects in patients. Read more
Investigation of the critical roles of platelets at the interface between thrombosis and inflammation in order to develop improved therapeutic strategies for the treatment and/or prevention of cardiovascular/inflammatory diseases
"Platelets (small circulating blood cells) are involved in blood clotting to prevent excessive bleeding, however, their inappropriate activation under pathological conditions leads to thrombosis resulting in major cardiovascular diseases such as heart attack and stroke. Read more
MSc by Research: Discovery of targeted protein degrader probes for central nervous system disease research
There are currently believed to be over 40 million people living with dementia globally, with no disease modifying treatments yet approved (Nichols, 2019). Read more