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medicinal chemistry PhD Projects, Programs & Scholarships

We have 79 medicinal chemistry PhD Projects, Programs & Scholarships

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  New Routes to Cyclic Sulfoximine 3-D Fragments for Medicinal Chemistry
  Prof P O'Brien
Applications accepted all year round

Funding Type

PhD Type

Background. The sulfoximine functional group is becoming increasingly popular within medicinal chemistry groups – notably, sulfoximines have featured in potential cancer treatments in clinical trials such as AZD6738 developed by AstraZeneca.
  Design and Synthesis of Bifunctional 3-D Building Blocks for Use in Medicinal Chemistry
  Prof P O'Brien
Applications accepted all year round

Funding Type

PhD Type

This project is in collaboration with Professor Mike Waring (Newcastle University). Background. Fragment-based methods are established for the identification of lead compounds in drug discovery.1 Fragments are small molecules (molecular weight ~150-300) which bind weakly to proteins.
  PhD Student in Organic/Medicinal Chemistry (New Antibiotics)
  Dr A Titz
Applications accepted all year round

Funding Type

PhD Type

The Helmholtz Association is the largest research organisation in Germany with over 40.000 employees. The Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) was founded between the Helmholtz Centre for Infection Research (HZI) and Saarland University in 2009.
  Exploiting druggability host spots in protein phosphatase targets
  Dr L Tabernero, Prof D Procter, Dr S Butterworth
Applications accepted all year round

Funding Type

PhD Type

In the past years the use of virtual screening or computer-based screening of compound libraries against selected targets has expanded exponentially the boundaries of drug discovery.
  PhD in Chemical Biology -- Neuropeptide Research -- University of Vienna
  Prof M Muttenthaler
Applications accepted all year round

Funding Type

PhD Type

Neuropeptides are key mediators in many biological functions and understanding their interaction with target proteins is fundamental to unravel the underlying mechanism of diseases.
  Development of antiviral peptidomimetic enzyme inhibitors
  Dr L Trembleau, Dr H Deng
Applications accepted all year round

Funding Type

PhD Type

Coronaviruses are a large group of viruses that circulate and evolve among various animals. They can cause mild human illnesses such as the common cold or more serious respiratory diseases as seen in the recent outbreaks of SARS (2002), MERS (2012), and COVID-19 (2019).
  Investigation of the critical roles of platelets at the interface between thrombosis and inflammation in order to develop improved therapeutic strategies for the treatment and/or prevention of cardiovascular/inflammatory diseases
  Dr S Vaiyapuri
Applications accepted all year round

Funding Type

PhD Type

"Platelets (small circulating blood cells) are involved in blood clotting to prevent excessive bleeding, however, their inappropriate activation under pathological conditions leads to thrombosis resulting in major cardiovascular diseases such as heart attack and stroke.
  Designing new molecules against Alzheimer’s disease using artificial intelligence techniques
  Dr A de la Vega de Leon, Prof B Chen
Application Deadline: 1 June 2020

Funding Type

PhD Type

The Sheffield Chemoinformatics Research Group is pleased to offer a fully-funded 3.5 year PhD studentship.
  Tyrosine kinase inhibitors conjugated tumour targeting dyes for the treatment of glioblastoma.
  Dr J Jose, Dr P Choi
Applications accepted all year round

Funding Type

PhD Type

Glioblastoma (GBM) remains a lethal and difficult to treat cancer with a dismal outcome. Although we have a better understanding of the disease progression, a concurrent increase in therapeutic intervention is lagging.
  Novel Cyclic Peptides for Biomedical Imaging and Therapeutic Targeting
  Prof M Zanda
Application Deadline: 1 September 2020

Funding Type

PhD Type

Cyclic Peptides have a wide range of applications as drugs and diagnostics, and have often higher receptor affinity, metabolic stability and better pharmacokinetic properties compared to their linear counterparts, but their synthesis still presents significant challenges.
  A chemical biology approach to identifying cyclic peptide protein-protein interaction inhibitors
  Prof A Tavassoli
Application Deadline: 31 August 2020

Funding Type

PhD Type

Supervisor. Ali Tavassoli. Project description. We are seeking a talented and motivated scientist to work on a 3.5 year interdisciplinary PhD project in the field of chemical biology, funded by a major US pharmaceutical company.
  Mapping the three dimensional structure of RNA
  Prof M Wills
Applications accepted all year round

Funding Type

PhD Type

We aim to combine organic synthetic chemistry, molecular biology, virology and computational biology tools to elucidate the 3D structure determinants behind RNA viruses such as dengue virus and coronaviruses.
  Bioorthogonal Chemistry and Fluorescent Post-Labeling for Real-Time Tracking of a Platinum-based Anticancer Drug
  Dr D Griffith, Dr D O’Shea
Applications accepted all year round

Funding Type

PhD Type

Metal-based drugs have a wide range of medicinal applications and are routinely used clinically as therapeutic and diagnostic agents.
  Identification of mlm receptor antagonists for treatment of cancer
  Dr R Foster
Applications accepted all year round

Funding Type

PhD Type

Recent high impact publications have identified antagonism of the mlm receptor as a possible target for treatment of cancer. The native ligand of the receptor has been linked to cell proliferation which has been proven to be as a result of increased nitric oxide (NO) concentration.
  Fostering development of ‘smart’, responsive therapeutics against cancer-related microRNAs.
  Dr E Bichenkova, Prof D Clarke, Dr H Aojula
Applications accepted all year round

Funding Type

PhD Type

Short functional non-coding microRNAs are implicated in many types of cancer, and thus can be used as biological targets for development of more selective and powerful anticancer therapies.
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