Masaryk University
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We have 52 medicinal chemistry PhD Projects, Programmes & Scholarships
medicinal chemistry PhD Projects, Programmes & Scholarships
We have 52 medicinal chemistry PhD Projects, Programmes & Scholarships
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Stereospecific Csp3-Csp2 Cross-Coupling of Saturated Heterocyclic Boronates: Application to a Modular Synthetic Platform for the Optimisation of Fragment Hits to 3-D Lead Compounds for Medicinal Chemistry
Background. A long-standing fundamental challenge in cross-coupling chemistry is the formation of stereodefined carbon-carbon bonds using Csp3-Csp2 Suzuki-Miyaura cross-coupling. Read more
Modular Synthetic Platform for the Optimisation of Fragment Hits to 3-D Lead Compounds for Medicinal Chemistry
Background. Fragment-based methods are established for the identification of lead compounds in drug discovery.[1] Fragments are small molecules (molecular weight ~150-300) which bind weakly to proteins. Read more
PhD in Chemistry: Medicinal Chemistry of Nucleotide Analogues
Nucleoside analogues (NAs) are an important class of antiviral and anticancer agents commonly used in the therapy of many different viral infections and cancer conditions. Read more
Fragment-Based Lead Generation of Small Molecule Inhibitors of the Nsp3 Macrodomain in SARS-CoV-2
Background. Coronaviruses (CoVs) are important human pathogens and SARS-CoV-2 is responsible for the current COVID-19 pandemic. Read more
Broadening the spectrum of antibacterial drugs to tackle multi-drug resistant Gram-negative pathogens
Research Group:
Astbury Centre for Structural Molecular Biology
Antibiotics make possible the treatment and cure of life-threatening bacterial infections and have added over a decade to average human lifespan. Read more
Synthesis of macrocycles and medium-sized rings via new ring expansion approaches
Summary. Macrocycles (12+ membered rings) and medium-sized rings (8–11-membered) are cyclic molecules with great potential in many scientific fields and technologies – especially in medicinal chemistry. Read more
Towards New Antivirals for the Treatment of COVID-19: Fragment-Based Lead Generation of Small Molecule Inhibitors of the Nsp3 Macrodomain in SARS-CoV-2
Background. Coronaviruses (CoVs) are important human pathogens and SARS-CoV-2 is responsible for the COVID-19 pandemic. Notwithstanding progress in available vaccines for COVID-19, there remains a need to develop small molecule drug candidates for treating COVID-19. Read more
Design and synthesis of chemical tools to interrogate cannabinoid receptors
Research project. We are seeking a highly motivated PhD candidate to join an interdisciplinary team at the University of Otago, to undertake research developing chemical probes for the cannabinoid receptor, a type of G protein-coupled receptor (GPCR). Read more
Boron in drug and chemical probe discovery
We are seeking strongly motivated and competitive candidates to conduct PhD research as part of an internationally-recognised research team involved in drug discovery and chemical probe design based on the element boron. Read more
Faculty of Pharmacy, Masaryk University
Discover the art of developing life-changing pharmaceuticals through our Medicinal Chemistry program. The aim of this programme is to prepare qualified experts who will work professionally in scientific activities in the field of development and analysis of drugs and its application to other scientific fields. Read more
PhD student Organic Synthesis of Glycomimetics & Antivirals
Helmholtz Centre for Infection Research
Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
Saarland University (UdS) is located in the Saarbrücken, Germany. The city is a state capital with 180.000 inhabitants, located between and well connected to Frankfurt, Paris, and Luxembourg. Read more
Synthesis of next-generation oligonucleotide therapeutics: fine tuning 2’ modification to enhance efficacy and cell uptake
Background. Oligonucleotide (ON) therapeutics is an exciting clinically approved platform for the treatment of a range of diseases not readily accessible by small molecule drugs. Read more
Investigation of the critical roles of platelets at the interface between thrombosis and inflammation in order to develop improved therapeutic strategies for the treatment and/or prevention of cardiovascular/inflammatory diseases
Platelets (small circulating blood cells) are involved in blood clotting to prevent excessive bleeding, however, their inappropriate activation under pathological conditions leads to thrombosis resulting in major cardiovascular diseases such as heart attack and stroke. Read more
MSc by Research: Discovery and evaluation of targeted protein degrader probes for central nervous system disease research
In the UK alone, neurodegenerative diseases will affect 2 million people by 2051, have very limited effective treatments and cost the economy £26.3Bn annually. Read more
Virology: Unique Antiviral Therapy targeting Zika and Related Viruses
Zika Virus (ZIKV) has emerged as a new mosquito-borne threat to public health after the devastating South American outbreak. Read more
