Background. Myeloid derived cell populations such as macrophages play a critical role in the early innate immune response, whilst dendritic cells are essential in bridging the progression to an adaptive immune response.
Our group is a world leader in targeting specific aspects of steroid metabolism to block cancer growth. Our research has been instrumental in the successful pre-clinical and clinical development of various novel anti-cancer compounds.
24-hour rhythms are present in virtually all aspects of our behaviour and physiology. These rhythms are underpinned by circadian clocks that run throughout the body, and act within each tissue to orchestrate many organ functions and rhythmic activities (e.g.
The gut epithelium is a complex setting of intestinal cells and epithelial cells filled with transporters, enzymes and channels; these cells are then populated by bacteria (microbiota) that help with the metabolism of nutrients and transport into the blood stream.
Our research is interdisciplinary and translational, combining magnetic resonance (MR) imaging and spectroscopy methods, immunohistochemistry and molecular biology to study cellular metabolism and blood flow regulation in health and disease.
Employing a range of approaches to address the physiological importance of the circadian:nuclear receptor system, ranging from population genetics, experimental medicine studies, CRISPR engineered mice, and cell biology.