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mice PhD Projects, Programmes & Scholarships
We have 51 mice PhD Projects, Programmes & Scholarships
Delineating the IRF6 regulatory network driving periderm formation and function
During development, the ectoderm passes through a series of cell states to produce a self-replenishing, multi-layered epidermis. Initial stratification forms a single-cell layer of flattened periderm cells which act as a barrier to prevent pathological adhesions during embryogenesis. Read more
Urokinase-plasminogen activator as a target to block osteoarthritic cartilage destruction
Osteoarthritis (OA) is one of the major causes of disability globally, which is particularly significant in an ageing population. Read more
MSc By Research: Using hypomethylating agents to prevent respiratory infections in older adults
The MSc by Research programme at the University of Aberdeen is for students interested in a research-intensive master's degree. It is designed specifically to enhance your skills for a PhD or research career. Read more
The impact of early life adversity on synaptic plasticity and memory—a novel therapeutic approach
Adverse childhood experiences (ACEs) are increasingly recognised as key risk factors for several negative health outcomes in adulthood, including addiction, chronic pain, anxiety disorders, depression, and memory impairment, many of which are highly co-morbid. Read more
The effect of early-life stress on cardiac function in later life
Stressful experiences in early childhood can increase the risk of cardiovascular disease (CVD) in later life. How early-life stress (ELS) influences susceptibility to CVD onset remains largely unknown. Read more
Ageing and body clock rhythms: The importance of a social network
It is popularly accepted that maintaining an active social life is paramount for good health and longevity. In its absence, social isolation and loneliness can elevate risk of disease and shorten lifespan. Read more
Cellular actions of neurosteroids: implications for post-traumatic stress disorder
Post-traumatic stress disorder (PTSD) is a highly debilitating psychiatric disorder that can arise following exposure to at least one traumatic event. Read more
Relationship between Tumour microenvironment and atherosclerotic cardiovascular disease during immunotherapy
Tumours actively escape the immune system by inducing an immunosuppressive state where intra-tumoural CD8 T-cells are “exhausted”, expressing an array of checkpoint inhibitory receptors, which results in a lack of effector functions. Read more
Microbiome metabolites as immune checkpoints
The symbiotic relationship between the gut microbiota and host immune system promotes homeostasis and a balanced microbial ecosystem. Read more
Resident memory B cell responses in the lung; immunity against pulmonary pathogens
Immunological memory of antibody responses is critical for the ability of the host to cope with secondary infections and is the basis for the development of most current vaccines. Read more
How does ageing influence intrinsic cartilage repair in osteoarthritis?
Articular cartilage breakdown is a hallmark of osteoarthritis (OA), the highly prevalent joint disease of ageing. Although previously regarded as a tissue with little intrinsic repair, even severely damaged articular cartilage is able to regenerate, given the correct biomechanical joint environment. Read more
The mechanism of the therapeutic potential of stem cell-derived Dendrobium Officinale sprouts (DOS) for gastric mucosa wound healing
Dendrobium Officinale (DO) is a traditional Chinese medicine for repairing gastrointestinal mucosa injuries. Plant stem cell-derived DO sprouts (SDO) exhibits more significant mucosa wound-healing effects than DO. Read more
The effect of age on arterial remodelling: relevance to atherosclerotic plaque progression and aneurysm formation
Atherosclerosis is an inflammatory vascular disease involving plaques composed of lipid-dense cores filled with activated, apoptotic and necrotic inflammatory and vascular cells coated with a fibrous cap. Read more
Investigations into the protective actions of CBD in the early synaptic deficits in dementia.
Accumulation of hyper-phosphorylated tau is a key event in Alzheimer’s disease (AD). Aberrant changes in tau cause synaptic abnormalities and cognitive deficits in early AD. Read more
Endothelial glycocalyx damage as a therapeutic target in sepsis-associated Acute Kidney Injury
Sepsis is the leading cause of acute kidney injury (sAKI), associated with high morbidity and mortality.1,2 Unfortunately, there is no treatment for sAKI, current therapies are nonspecific and supportive of the vital organ systems in the hope the kidney will recover. Read more