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microglia PhD Projects, Programs & Scholarships

We have 12 microglia PhD Projects, Programs & Scholarships

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  Understanding Neuroinflammation through advanced in vitro 3D modelling using human Pluripotent Stem Cells
University of Oxford BBSRC Interdisciplinary Bioscience DTP
  Dr S Cowley, Prof W S James
Application Deadline: 25 January 2019
Microglia - brain-resident macrophages - carry out homeostatic surveillance functions in the brain, clearing dying cells, extracellular debris, and pruning synapses during development.
Details
Type/Funding
  Modulatory functions of microglia on medium spiny neuron function and degeneration in stem cell models of Huntington’ Disease
Cardiff University Cardiff School of Biosciences
  Prof N Allen, Prof A Rosser
Application Deadline: 15 December 2018
Studentship Summary. This studentship is part of a SCTN-Training network of 14 studentships, funded by the European Union Horizon 2020 Programme (H2020-MSCA-ITN-2018) under the Marie Skłodowska-Curie Initial Training Network and Grant Agreement No.
Details
Type/Funding
  MRC DiMeN Doctoral Training Partnership: How interferon defends the brain against viral invasion
Newcastle University MRC DiMeN Doctoral Training Partnership
  Dr C Duncan, Prof S Hambleton, Dr D Rico, Prof W S James
Application Deadline: 21 January 2019
Contrary to the perception of the brain as an ‘immune-privileged’ organ, it is now clear that the brain engages a potent immune signalling network to defend itself against viral infection (encephalitis).
Details
Type/Funding
  Identifying the role of glycosaminoglycans and microglia in early pathology of mucopolysaccharide diseases
University of Manchester Faculty of Biology, Medicine and Health
  Dr B BIgger, Dr R Holley, Prof S Flitsch
Applications accepted all year round
Mucopolysaccharidoses (MPS) are inherited metabolic disorders caused by the deficiency of specific lysosomal enzymes required for the catabolism of glycosaminoglycans (GAGs) where each MPS type lacks a specific enzyme resulting in the build-up of GAGs in all cells of the body.
Details
Type/Funding
  Using biomaterials and 3D bioprinting to model the neurovascular unit in dementia
University of Manchester Faculty of Biology, Medicine and Health
  Prof N Hooper, Dr M Domingos, Dr T Wang
Applications accepted all year round
Neurovascular dysfunction is a central process in the pathogenesis of Alzheimer’s disease and other dementias. In the brain, cerebrovasculature and neuronal structures are tightly integrated forming the multicellular neurovascular unit comprising endothelial cells, astrocytes, microglia and neurons.
Details
Type/Funding
  Investigation of the anti-inflammatory effect of curcumin in a mouse model of chronic neuroinflammation – a route for a cure for Alzheimer’s disease?
Western Sydney University School of Medicine
  Dr E Gyengesi, Prof GM Muench
Applications accepted all year round
This project will investigate the effect of chronic glial activation on brain structure and function, and test the efficacy of two cytokine-suppressive anti-inflammatory drugs (CSAIDs) against chronic glial activation and the resulting neuronal damage.
Details
Type/Funding
  Role of vitamin D in neuroinflammation
University of Edinburgh College of Medicine and Veterinary Medicine
  Research Group: Centre for Clinical Brain Sciences
  Dr D Sieger, Dr A Astier
Application Deadline: 7 February 2019
T cells play a central role in the inflammation occurring in multiple sclerosis (MS), and migration of activated T cells into the CNS is key to MS pathogenesis.
Details
Type/Funding
  Simons Initiative for the Developing Brain (SIDB) PhD Studentships 2019
University of Edinburgh
Simons Initiative for the Developing Brain (SIDB). PhD Studentships 2019. Applications are invited for four 3.5 year full-time fully funded PhD studentships spanning basic and translational brain sciences in the biological mechanisms underlying autism.
Details
Type/Funding
  Investigating the link between amyloid-β oligomers, neuroinflammation and cognitive deficits in preclinical models for Alzheimer’s Disease
University of Manchester Faculty of Biology, Medicine and Health
  Dr M Harte, Prof J Neill
Applications accepted all year round
Currently four out of the five pharmacological treatments used for Alzheimer’s disease (AD) are acetylcholinesterase inhibitors aimed at boosting the amount of acetylcholine in the brain, with the fifth being an N-methyl-D-aspartate (NMDA) receptor antagonist.
Details
Type/Funding
  Understanding how inflammation affects brain disease
University of Manchester Faculty of Biology, Medicine and Health
  Dr D Brough, Dr C Lawrence
Applications accepted all year round
We know that both peripheral and central inflammation influence neurological disease. This influence progresses and worsens diverse brain diseases, but the mechanisms involved are poorly understood.
Details
Type/Funding
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