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We have 11 microglia PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
microglia PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 11 microglia PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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Computational and cell biological studies to understand the regulation of microglia by a novel Alzheimer’s disease risk gene
Advances have been made through large-scale study of patients genetic make-up, which have pointed to a number of genes, particularly those of the immune system, being involved in the development of Alzheimer’s disease. Read more
Early life perturbations and neurological disorders in later life
The formation of the brain involves a complex choreography of events and players during development. While this process is continuous, there are however critical periods in which this process is particularly susceptible to perturbations. Read more
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Lipid droplets and the regulation of inflammation by macrophages
Lipid droplets are important intracellular particles that comprise neutral lipids surrounded by a phospholipid monolayer. They are a major reservoir for lipids that are then provided for energy, membrane biosynthesis and for signalling intermediates. Read more
Neuroimmunology of concussion
Concussion, or mild traumatic brain injury, affects millions world-wide each year. It is now appreciated that a history of concussion increases the risk of developing long-term emotional and neurocognitive disorders. Read more
Cancer Neuroscience: Investigating the impact of non-CNS tumours on neuronal plasticity in the brain
Cancer is one of the leading causes of death worldwide, resulting in approximately 18 million new cases and 10 million deaths each year. Read more
MScR - Early-life stress, susceptibility to mental health disorders and glia: central immune response in a rat model of pre-term birth
Depression and anxiety are the most prevalent mental health disorders affecting 1 in 4 people in the UK. Depression is the second most common cause of disability and together with other mental health disorders costs the UK economy an estimated £105 billion per year. Read more
Investigating the link between amyloid-β oligomers, neuroinflammation and cognitive deficits in preclinical models for Alzheimer’s Disease
Currently four out of the five pharmacological treatments used for Alzheimer’s disease (AD) are acetylcholinesterase inhibitors aimed at boosting the amount of acetylcholine in the brain, with the fifth being an N-methyl-D-aspartate (NMDA) receptor antagonist. Read more
Exploring the effect of hypoxia upon glioblastoma progression and response to treatments using a dynamic 3D iPSC-brain organoid
Background. Glioblastoma (GBM) is the most aggressive brain tumour, displaying considerable resistance to drug-/radiation-therapies. Read more
Investigate neuron-glia interactions in MND using advanced molecular and microscopy techniques
This project aims to characterise some of the fundamental interactions between motor neurons and glial cells (microglia, astrocytes, and oligodendrocytes) in the CNS. Read more
Understanding how inflammation affects brain disease
We know that both peripheral and central inflammation influence neurological disease. This influence progresses and worsens diverse brain diseases, but the mechanisms involved are poorly understood. Read more
Molecular mechanism of innate immunity mediated by the Toll/IL1 receptor signalling pathways
Our research aims to elucidate the molecular and cellular regulation of innate immune signal transduction in the context of infectious, inflammatory and autoimmune disease. Read more
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