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microglia PhD Projects, Programs & Scholarships

We have 9 microglia PhD Projects, Programs & Scholarships

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  PhD in Dementia Research - Alzheimer’s disease: Understanding the interaction of microglia risk genes
  Prof P Taylor, Dr E Lloyd-Evans
Application Deadline: 31 March 2019
Microglia, the immune cells of the brain, may be protective in Alzheimer’s disease, encircling amyloid plaques, clearing debris and limiting further inflammatory damage.
  TREM2 regulation of microglial dynamics
  Prof J Kittler
Application Deadline: 8 April 2019
This studentship is focused on understanding the cellular basis of microglial function through the study of TREM2, with the aim of opening up new avenues for intervention in disease.
  Identifying the role of glycosaminoglycans and microglia in early pathology of mucopolysaccharide diseases
  Dr B BIgger, Dr R Holley, Prof S Flitsch
Applications accepted all year round
Mucopolysaccharidoses (MPS) are inherited metabolic disorders caused by the deficiency of specific lysosomal enzymes required for the catabolism of glycosaminoglycans (GAGs) where each MPS type lacks a specific enzyme resulting in the build-up of GAGs in all cells of the body.
  PhD in Dementia Research - Microglial NFAT signalling and Alzheimer’s disease genetic risk networks
  Dr M Hill
Application Deadline: 31 March 2019
Genome-wide association studies (GWAS) have identified robust risk loci for Alzheimer’s disease (AD). These findings serve as a starting point for novel biological investigation and treatment strategies.
  Using biomaterials and 3D bioprinting to model the neurovascular unit in dementia
  Prof N Hooper, Dr M Domingos, Dr T Wang
Applications accepted all year round
Neurovascular dysfunction is a central process in the pathogenesis of Alzheimer’s disease and other dementias. In the brain, cerebrovasculature and neuronal structures are tightly integrated forming the multicellular neurovascular unit comprising endothelial cells, astrocytes, microglia and neurons.
  Investigation of the anti-inflammatory effect of curcumin in a mouse model of chronic neuroinflammation – a route for a cure for Alzheimer’s disease?
  Dr E Gyengesi, Prof GM Muench
Applications accepted all year round
This project will investigate the effect of chronic glial activation on brain structure and function, and test the efficacy of two cytokine-suppressive anti-inflammatory drugs (CSAIDs) against chronic glial activation and the resulting neuronal damage.
  A novel approach to manage neuroinflammation-driven central neuropathic pain after spinal cord injury
  Dr W Huang, Prof C McCaig, Prof R Pertwee
Application Deadline: 29 March 2019
Worldwide, spinal cord injury (SCI) affects around 2.5 million people with estimated additional 500,000 new cases annually. About 50% of SCI patients suffer from central neuropathic pain (CNP), which has a major impact on daily functioning, affect rehabilitation, and often leads to depressive and suicidal states.
  Investigating the link between amyloid-β oligomers, neuroinflammation and cognitive deficits in preclinical models for Alzheimer’s Disease
  Dr M Harte, Prof J Neill
Applications accepted all year round
Currently four out of the five pharmacological treatments used for Alzheimer’s disease (AD) are acetylcholinesterase inhibitors aimed at boosting the amount of acetylcholine in the brain, with the fifth being an N-methyl-D-aspartate (NMDA) receptor antagonist.
  Understanding how inflammation affects brain disease
  Dr D Brough, Dr C Lawrence
Applications accepted all year round
We know that both peripheral and central inflammation influence neurological disease. This influence progresses and worsens diverse brain diseases, but the mechanisms involved are poorly understood.
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