Microtubule associated protein 2c (MAP2c) is a key factor regulating microtubule dynamics in developing brain neurons, and an example of an intrinsically disordered proteins with an important physiological function and detectable structure-function relationship.
Lung cancer is the leading cause of cancer-related mortality worldwide. Approximately 5% of patients express the EML4-ALK oncogenic fusion that joins the EML4 microtubule-associated protein to the tyrosine kinase domain of ALK.
Autophagy is an essential catabolic process that promotes cell survival during episodes of nutrient/growth factor stress. Autophagy is involved in many human diseases, so complete understanding of this process is needed.