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missile PhD Projects, Programmes & Scholarships
We have 3 missile PhD Projects, Programmes & Scholarships
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Expanding the ligandable E3 ubiquitin ligases for targeted protein degradation
Out of more than 600 E3 ubiquitin ligases in cells, currently only a handful have small molecule binders that can be used for PROteolysis Targeting Chimeras (PROTACs) and harnessed for targeted protein degradation. Read more
Bifunctional small molecules beyond PROTACs: Proximity-inducing new downstream chemistries to rewire cell signalling
Proteolysis targeting chimeras (PROTACs) are a popular class of bifunctional molecules that simultaneously engage a target protein on one end and an E3 ubiquitin ligase on the other end, forming a ternary complex that facilitates the rapid ubiquitylation and subsequent degradation of the target protein. Read more
Leveraging reversible phosphorylation and ubiquitylation pathways for innovative drug discovery approaches
Reversible ubiquitylation and phosphorylation are fundamental processes that control cellular signalling through regulation of protein stability and function. Read more
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