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mitochondria PhD Projects, Programmes & Scholarships
We have 32 mitochondria PhD Projects, Programmes & Scholarships
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Mitochondria in ischaemia-reperfusion injury
Mitochondrial production of free radicals and subsequent oxidative damage has long been known to contribute to damage in conditions such as ischaemia-reperfusion (IR) injury in stroke and heart attack. Read more
Mitochondria in ischaemia-reperfusion injury
Mitochondrial production of free radicals and subsequent oxidative damage has long been known to contribute to damage in conditions such as ischaemia-reperfusion (IR) injury in stroke and heart attack. Read more
Unravelling the effects of mitochondrial replacement therapy on mtDNA transmission
Commercial partner: Juno Genetics. Normal oocytes contain ~100,000 copies of mtDNA, which are effectively identical. Patients with mtDNA disease may harbour both mutant and normal mtDNA (heteroplasmy). Read more
Translational potential of novel mitochondrial-targeted nanoparticles encapsulating hydrogen sulphide as modulators of neurological disease.
Neurodegenerative disorders such as Parkinson’s disease occur due to the progressive and irreversible degeneration of nerve cells. Read more
Finding the eat-me signals
The Ganley lab is interested in unravelling the molecular mechanism of autophagy (which literally translates from the Greek meaning to eat oneself). Read more
The role of mitochondrial membrane remodelling in controlling mtDNA levels and heteroplasmy
Mitochondria are dynamic organelles generating a specific network by membrane remodeling events according to cellular needs1. Mitochondria contain multiple copies of their own genome, mtDNA, a circular molecule that encodes for 13 proteins involved in energy production through oxidative phosphorylation. Read more
The role of mitochondrial membrane remodelling in controlling mtDNA levels and heteroplasmy
Mitochondria are dynamic organelles generating a specific network by membrane remodeling events according to cellular needs1. Mitochondria contain multiple copies of their own genome, mtDNA, a circular molecule that encodes for 13 proteins involved in energy production through oxidative phosphorylation. Read more
Structure and mechanism of the human mitochondrial ADP/ATP carrier
The mitochondrial ADP/ATP carrier, also called the adenine nucleotide translocase, imports ADP into the mitochondrial matrix and exports ATP, which are key steps in oxidative phosphorylation. Read more
Structure and mechanism of the human mitochondrial ADP/ATP carrier
The mitochondrial ADP/ATP carrier, also called the adenine nucleotide translocase, imports ADP into the mitochondrial matrix and exports ATP, which are key steps in oxidative phosphorylation. Read more
The Survivin Interactome in Health and Disease
Survivin is a small protein that is essential for life but that also contributes to disease, most notably cancer, in which its abnormal overexpression is linked to therapeutic resistance and metastasis. Read more
Understanding the interaction and functional mechanism of mitochondrial MIA pathway
Mitochondria are vitally important organelles of living cells, which generate the primary energy for all biological activities. Mitochondrial dysfunction leads to life threatening diseases, such as cancer, diabetes, stroke, and various neurodegenerative diseases (e.g. Read more
Understanding apoptotic heterogeneity in cell populations
Apoptosis is a form of programmed cell death that occurs in response to stress such as genomic damage. The decision to initiate apoptosis is taken at the outer mitochondrial membrane (OMM) by members of the Bcl-2 family of proteins. Read more
Multimodal imaging of brain metabolism in humans in vivo
The overall goal of this PhD thesis is the development and implementation of metabolic imaging techniques, including arterial spin labelling (ASL) perfusion MRI1 and quantitative BOLD MRI2 , for a comprehensive assessment of oxygen metabolism in the healthy brain at baseline. Read more
White Rose BBSRC DTP: Molecular mechanism of organellar replication initiation in Plasmodium falciparum
We invite applications for a BBSRC funded White Rose Doctoral Training Program (DTP) studentship to study how organellar replication functions in Plasmodium, the pathogen responsible for causing malaria. Read more
Genetic approaches for rational development of animal models of complex I-linked mitochondrial disease
Mutations in mitochondrial complex I genes are common causes of primary mitochondrial neuromuscular diseases such as Leigh syndrome. Read more
