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We have 35 mitochondrial PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
mitochondrial PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 35 mitochondrial PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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Investigation of aortic remodelling in obesity and role of mitochondrial dysfunction
Obesity is a global healthcare and economic burden with currently more than 650 million adults classified as obese (WHO, 2017). Obesity is a common precursor to type 2 diabetes (T2DM), and both are risk factors for developing cardiovascular disease. Read more
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Identification and functional analysis of human mitochondrial mRNA regulatory factors
Laboratory of RNA Biology IBB PAS. seeks a highly motivated PhD Student candidate who would like to join a mitochondrial research group working under the supervision of Dr Roman Szczesny. Read more
Translational potential of novel mitochondrial-targeted nanoparticles encapsulating hydrogen sulphide as modulators of neurological disease.
Neurodegenerative disorders such as Parkinson’s disease occur due to the progressive and irreversible degeneration of nerve cells. Read more
Assessing the Impact of Aggregation-Prone Proteins on the Mitochondrial-Metallome Interplay in a Novel 3D Spheroid Cholinergic Cell Model of Neurodegenerative Disease
Although showing diverse symptoms affecting cognition and movement, the brains of patients with neurodegenerative disorders (NDs) display similar neuropathological features namely protein aggregation within the brain. Read more
Determining the role of mitochondrial DNA variation in hepatic pathways and its impact on physiology, pharmacology and toxicology: a combined in vitro and bioinformatic approach.
Project Background and Aims. It is widely known that differences in the nuclear genome contribute to aspects of us as individuals, from hair colour to lifespan. Read more
Understanding the interaction and functional mechanism of mitochondrial MIA pathway
Mitochondria are vitally important organelles of living cells, which generate the primary energy for all biological activities. Mitochondrial dysfunction leads to life threatening diseases, such as cancer, diabetes, stroke, and various neurodegenerative diseases (e.g. Read more
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Probe mechanisms underlying the maternal inheritance of mitochondrial DNA in Drosophila
We seek a highly motivated PhD student to join our dynamic group investigating mitochondrial genetics and function (. http://themalab.co.uk. Read more
MSc by Research: Investigation of mitochondrial biology and neurodegeneration
Phosphorylation and ubiquitylation are reversible signalling events and there is significant interest in in their interplay in the regulation of normal biological processes and disruption in human diseases. Read more
Investigating the Mitotoxicity of Fluoroquinolone Antibiotics
Applications are invited for a self-funded, 3 year full-time or 6 year part-time PhD project. The PhD will be based in the School of Pharmacy and Biomedical Science and will be supervised by Dr Robert Baldock. Read more
Structure and function of the mitochondrial DNA network in trypanosomatid parasites
Research Group:
Edinburgh Infectious Diseases
Project offered for Ker Memorial PhD Studentship in Infectious Diseases at the University of Edinburgh. Trypanosomatid parasites cause devastating diseases in humans and their livestock, and these diseases predominantly affect low- and middle-income countries. Read more
Bioenergetic connectivity brain mapping in Parkinson’s disease
Background. Mitochondrial dysfunction is a key mechanism leading to neuronal cell loss in Parkinson’s disease (PD) but tools are currently lacking to identify those patients most likely to respond to mitochondrial rescue therapy to enable Precision Medicine approaches or provide evidence of target engagement. Read more
Mechanisms of metabolic remodelling in obesogenic/diabetic cardiomyopathy
Obesity is a worldwide public health concern and is one of the co-morbidities associated with the development of type 2 diabetes. Read more
Understanding apoptotic heterogeneity in cell populations
Apoptosis is a form of programmed cell death that occurs in response to stress such as genomic damage. The decision to initiate apoptosis is taken at the outer mitochondrial membrane (OMM) by members of the Bcl-2 family of proteins. Read more
TARGETING MITOPHAGY TO REDUCE CHEMOTHERAPY-INDUCED PAIN
"Background. Chemotherapy-induced peripheral neuropathy (CIPN) is the most commonly reported side effect of chemotherapeutic drugs, affecting quality of life in many cancer patients. Read more
Development of individualised approaches for the treatment of Hereditary Spastic Paraplegia caused by spastin mutations
Hereditary spastic paraplegia (HSP) is an inherited neurological disease primarily affecting upper motor neurons (UMNs), but with a range of other pathologies dependent on the underlying genetic mutation. Read more