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mitosis PhD Projects, Programmes & Scholarships
We have 8 mitosis PhD Projects, Programmes & Scholarships
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Role of APC/C subunit post-translational modifications on the function of the APC/C in mitosis
The APC/C is a large macromolecular E3 ubiquitin ligase, that, through targeting protein substrates for polyubiquitylation and 26S proteasome-mediated degradation coordinates the progression of cells through mitosis (1, 2). Read more
Medical Research Council (MRC) Cancer and Genome Integrity PhD Programme 2023
Defects in DNA replication or DNA repair can lead to mutations and other genomic alterations that give rise to cancers, and consequently tumours tend to have a high degree of genome instability. Read more
How does the TRAIP ubiquitin ligase guard the mammalian genome from damage?
The TRAIP ubiquitin ligase is a key regulator of genome integrity in mammalian cells. The importance of TRAIP is highlighted by the fact that mutation leads to a human disease syndrome, whilst over-expression of TRAIP can be associated with human cancer. Read more
MSc by Research: Molecular Analysis of Nuclear Bodies and RNP Trafficking Pathways in the Cell Nucleus
Many important processes within mammalian cells are compartmentalised within specific subcellular structures. In the cell nucleus, Nuclear Bodies (NBs), such as nucleoli, provide specialised compartments that are not surrounded by membranes, but still concentrate specific proteins and RNAs. Read more
MSc by Research: Investigation of the interplay between the cell cycle and Notch intracellular domain levels in presomitic mesoderm cells in somitogenesis
One of the key processes in embryo development is somitogenesis. This is the formation of segments, known as somites, that go on to develop into bone and skeletal muscle. Read more
MSc by Research: Identification of PP2A substrates during oocyte meiosis
Female meiosis is particularly error-prone, leading to chromosomally abnormal embryos that account for >10% of human pregnancies and, for women nearing menopause, the incidence may exceed 50%. Read more
How does paclitaxel kill cells and why do some cells evade it?
Paclitaxel (Taxol) is a microtubule-stabilizing drug widely used for the treatment of breast, ovarian and lung cancers. For many years, it was thought to kill cancer cells by inducing mitotic arrest, thus preventing proliferation. Read more
Deciphering a novel anti-ageing epigenetic programme
Over two decades of intense research in the field of epigenetics have produced compelling evidence that chromatin modifications are crucial for processes such as DNA repair, transcription, splicing, mitosis, meiosis, and in the preservation of the epigenetic memory of cells. Read more
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