Development of novel nano-agents to target DNA replication forks and modulate cell cycle and activity
Prof M Hannon, Dr N J Hodges, Prof G Stewart
6 January 2019
We have developed a novel class of metal-based cylinders that bind to DNA Y-shaped junctions. These cylinders show an exciting activity to push rapidly dividing cells into cytostasis (in cell line studies) but we want to further understand the basic cell and molecular biology of these agents in more detail specifically.