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We have 45 molecular pharmacology PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
molecular pharmacology PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 45 molecular pharmacology PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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Funded MSc by Research: Uncovering the Pharmacology of GPR75: a Promising G Protein-Coupled Receptor Target for Metabolic Syndrome
G protein-coupled receptors (GPCRs), due to their cell surface expression, their tissue-selective distribution and role in amplifying signalling events make them excellent pharmacological targets, hence over 30% of current approved drugs target GPCRs (1). Read more
PHD / MSCR PROJECT: How neurones engage astrocytes in network activity
It is now firmly established that in the mammalian brain neuronal networks cannot successfully perform their functions without concomitant metabolic and signalling support from the adjacent glial cells, called astrocytes. Read more
Structure-based design of allosteric modulators for G protein-coupled receptors using molecular modelling and pharmacology experiments
Almost all physiological processes are regulated through the activation of G protein-coupled receptors (GPCRs). It has become widely accepted that most GPCRs possess binding sites spatially distinct from their natural ligand binding site (orthosteric site), termed as allosteric sites. Read more
Determining the role of mitochondrial DNA variation in hepatic pathways and its impact on physiology, pharmacology and toxicology: a combined in vitro and bioinformatic approach.
Project Background and Aims. It is widely known that differences in the nuclear genome contribute to aspects of us as individuals, from hair colour to lifespan. Read more
SELF-FUNDED MSC BY RESEARCH: ABCC9 mutations and risk of sudden cardiac death
Sudden cardiac death (SCD) is an important clinical problem and has a lasting impact on relatives of the deceased, particularly when sudden death occurs… Read more
SELF-FUNDING MSc BY RESEARCH PROJECT: Circadian Oscillators in Drinking and Feeding Brain Circuits.
Daily or circadian rhythms pervade all aspects of our physiology and behaviour (Hastings et al., 2018). By convention, these rhythms are attributed to the activity of the brain’s suprachiasmatic nuclei (SCN). Read more
MSC BY RESEARCH - Preserving t-tubule function in adult cardiac myocytes in short-term culture
Invaginations of the sarcolemma of adult cardiac myocytes known as transverse (or t-) tubules account for up to 65% of the total sarcolemma surface and play a key role in excitation-contraction (EC) coupling and cell signalling (Hong & Shaw, 2017). Read more
MSC BY RESEARCH: Involvement of astrocytes in neurological manifestations of Long COVID syndrome
A significant fraction of patients affected by Long COVID, long-term consequences following acute SARS-CoV-2 infection, suffer from mental fatigue and cognitive deficits (1-3). Read more
SELF-FUNDED MSC BY RESEARCH: Modulation of Brain Energy Metabolism by Astrocytic G-protein-coupled Receptors
It has become increasingly clear that ‘neuro’science research must consider the roles of non-neuronal cells in the central nervous system if integrated brain function is to be ultimately understood. Read more
MScR - Determining the genetic and circadian basis of bipolar disorder using Drosophila
Circadian rhythms and sleep are evolutionarily conserved from fruit flies (Drosophila) and are fundamental as well as vital to biology and health (Jagannath et al., 2017; Menet and Rosbash, 2011). Read more
MScR - Astrocyte mechanisms in depression
Depression is the most common mental health illness affecting about 20% of the population at least once in their lifetime. Depression has been proposed to be a result of a decreased level of brain monoamines such as serotonin. Read more
Investigation of aortic remodelling in obesity and role of mitochondrial dysfunction
Obesity is a global healthcare and economic burden with currently more than 650 million adults classified as obese (WHO, 2017). Obesity is a common precursor to type 2 diabetes (T2DM), and both are risk factors for developing cardiovascular disease. Read more
The epigenomic, transcriptional and diagnostic architecture of neurodevelopmental disorders caused by exposure to maternal infection
A fundamental unknown in understanding mechanisms of disease, and therefore improving therapy, is how stressors experienced during critical developmental periods influence the genesis or ‘programming’ of adult disease (Estes & McAllister 2016). Read more
Assessment of matrix metalloproteinase 9 inhibitor for the treatment of severe skin-blistering adverse drug reactions using in vitro and ex vivo skin models.
Stevens-Johnson syndrome and toxic epidermal necrolysis are rare, immune-related, severe skin-blistering reactions which can be caused by a wide range of commonly administered drugs. SJS/TEN is characterised by wide-spread skin (epidermal) detachment and recent work in our lab has identified a number of potential molecular mechanism by which this could occur. Read more
Modulation of neuronal circuits using non-invasive ultrasound stimulation
The research project is based on recent functional studies that conclusively demonstrated the capacity of transcranial low-intensity ultrasound stimulation to reversibly activate or suppress neural activity with high spatial specificity in vivo. Read more