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We have 45 molecular pharmacology PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships



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molecular pharmacology PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships

We have 45 molecular pharmacology PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships

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Funded MSc by Research: Uncovering the Pharmacology of GPR75: a Promising G Protein-Coupled Receptor Target for Metabolic Syndrome

G protein-coupled receptors (GPCRs), due to their cell surface expression, their tissue-selective distribution and role in amplifying signalling events make them excellent pharmacological targets, hence over 30% of current approved drugs target GPCRs (1). Read more

PHD / MSCR PROJECT: How neurones engage astrocytes in network activity

It is now firmly established that in the mammalian brain neuronal networks cannot successfully perform their functions without concomitant metabolic and signalling support from the adjacent glial cells, called astrocytes. Read more

Structure-based design of allosteric modulators for G protein-coupled receptors using molecular modelling and pharmacology experiments

Almost all physiological processes are regulated through the activation of G protein-coupled receptors (GPCRs). It has become widely accepted that most GPCRs possess binding sites spatially distinct from their natural ligand binding site (orthosteric site), termed as allosteric sites. Read more

MSC BY RESEARCH - Preserving t-tubule function in adult cardiac myocytes in short-term culture

Invaginations of the sarcolemma of adult cardiac myocytes known as transverse (or t-) tubules account for up to 65% of the total sarcolemma surface and play a key role in excitation-contraction (EC) coupling and cell signalling (Hong & Shaw, 2017). Read more

MScR - Determining the genetic and circadian basis of bipolar disorder using Drosophila

Circadian rhythms and sleep are evolutionarily conserved from fruit flies (Drosophila) and are fundamental as well as vital to biology and health (Jagannath et al., 2017; Menet and Rosbash, 2011). Read more

MScR - Astrocyte mechanisms in depression

Depression is the most common mental health illness affecting about 20% of the population at least once in their lifetime. Depression has been proposed to be a result of a decreased level of brain monoamines such as serotonin. Read more

Investigation of aortic remodelling in obesity and role of mitochondrial dysfunction

Obesity is a global healthcare and economic burden with currently more than 650 million adults classified as obese (WHO, 2017). Obesity is a common precursor to type 2 diabetes (T2DM), and both are risk factors for developing cardiovascular disease. Read more

The epigenomic, transcriptional and diagnostic architecture of neurodevelopmental disorders caused by exposure to maternal infection

A fundamental unknown in understanding mechanisms of disease, and therefore improving therapy, is how stressors experienced during critical developmental periods influence the genesis or ‘programming’ of adult disease (Estes & McAllister 2016). Read more

Assessment of matrix metalloproteinase 9 inhibitor for the treatment of severe skin-blistering adverse drug reactions using in vitro and ex vivo skin models.

Stevens-Johnson syndrome and toxic epidermal necrolysis are rare, immune-related, severe skin-blistering reactions which can be caused by a wide range of commonly administered drugs. SJS/TEN is characterised by wide-spread skin (epidermal) detachment and recent work in our lab has identified a number of potential molecular mechanism by which this could occur. Read more

Modulation of neuronal circuits using non-invasive ultrasound stimulation

The research project is based on recent functional studies that conclusively demonstrated the capacity of transcranial low-intensity ultrasound stimulation to reversibly activate or suppress neural activity with high spatial specificity in vivo. Read more

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