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We have 6 molecular docking PhD Projects, Programmes & Scholarships
molecular docking PhD Projects, Programmes & Scholarships
We have 6 molecular docking PhD Projects, Programmes & Scholarships
Funded PhD - Unlocking the secrets of fentanyl: exploring the anomalous pharmacology of fentanyl at the µ-opioid receptor
Fentanyl is a potent synthetic opioid that is fuelling an ongoing epidemic of drug overdose deaths in the US. Like other opioids, such as morphine, fentanyl and its derivatives act on the µ-opioid receptor (MOR), which is a key player in pain modulation. Read more
Computational and machine learning driven development of new polysialyltransferase (ST8SiaII) inhibitors against metastatic cancer
Research Group:
Institute of Cancer Therapeutics
Polysialic acid (polySia) is a carbohydrate polymer important for embryonic development. PolySia is absent in healthy adult tissues whereas overexpressed in several tumours. Read more
Exploring the TMEM206 proton-gated chloride channel as a new therapeutic target in ischaemic-mediated capillary disfunction
Commercial partner: Novo Nordisk Research Centre Oxford (NNRCO). Mammalian cells respond to alterations in extracellular pH (pHe) with mechanisms that are aimed at re-establishing cellular homeostasis. Read more
Sweet disposition: combatting bacterial infections and antimicrobial resistance with designer proteins that target biofilm matrix carbohydrates
Microorganisms grow as biofilms on surfaces, from teeth to surgical implants or even the lining of the lungs. Biofilms are dense cell aggregates embedded in a complex matrix of molecules that surrounds and protect the cells. Read more
Therapeutic resolution of coronavirus (COVID-19) diseases by natural products
Research Group:
Pharmacology and Experimental Therapeutics
Coronavirus now labelled as Covid-19 has become a global pandemic affecting around 200 countries. Currently neither any cure nor any vaccine for Covid-19 has been established. Read more
What is the interrelationship between cell mitosis and cell polarity during apical-basal polarisation of epithelial organs?
My group strives to uncover how mechanics and biochemical signalling work together to shape epithelial organs during development. Read more
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