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We have 98 mouse PhD Projects, Programmes & Scholarships

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mouse PhD Projects, Programmes & Scholarships

We have 98 mouse PhD Projects, Programmes & Scholarships

Driving phenotypic plasticity and metastasis in small cell lung cancer

Small cell lung cancer (SCLC) is an aggressive malignancy with poor prognosis. Underlying this aggressiveness is intra-tumoural heterogeneity driven by phenotypic plasticity wherein tumour cells transition from a neuroendocrine (NE) to a non-neuroendocrine (non-NE) phenotype. Read more

The use of life course epidemiology to support the experimental characterisation of genetic variation

Project Background. There has been a rapid expansion in the generation of genetic sequence data over the last decade. Understanding the potential relevance of genetic mutations to human health remains challenging. Read more

Novel mechanisms of skeletogenesis

Affiliation. Masaryk University, Faculty of Medicine. Study program. PhD program Biomedical Sciences. Specialization. Biochemistry and Molecular Biology . Read more

Functions of cyclin-dependent kinase 11 (CDK11) in regulation of gene expression and tumorigenesis

Doctoral study program. Life Sciences. Research area. RNA/nucleic acids research in health, cancer biology. CDK11 is ubiquitously expressed in all tissues and the CDK11 null mouse is lethal at an early stage of development indicating an important role for Cdk11 in the adult as well as during development. Read more

Retrotransposons in immunity

Only about 1-2% of our genome is made up of protein coding genes, the rest is non-coding and at least half of that is made up of repetitive DNA sequences known as transposable elements (TEs). Read more

Feeding microbes to protect the brain: does the gut microbiota mediate the risk-reducing effects of a healthy diet on Alzheimer’s disease?

Background. Ways of reducing the risk of developing Alzheimer’s disease (AD) and other dementias are critically needed, given the almost total lack of truly effective therapeutic options, even despite newer anti-amyloid drugs1. Read more

Understanding transcription factor complexes controlling endothelial cell quiescence and escape from quiescence

Endothelial cell proliferation and lymphatic cell proliferation is initiated during angiogenesis and lymphangiogenesis respectively and are both regulated by the VEGF signalling pathway. With some exceptions, endothelial and lymphatic cells in healthy individuals are quiescent and do not proliferate. Read more

Investigating the communication between cancer cells and cells in the tumour microenvironment to improve our understanding of epigenetic regulatory mechanisms and identify new targets for cancer therapy

It is well-established that the molecular mechanisms controlling gene expression are disrupted in cancer cells and work in this area has laid the foundations for targeted cancer therapies. We are interested in the regulatory pathways that control cell proliferation and cell migration and the events that disrupt this control in multiple types of cancer. Read more

Protecting Mum: how hormones act on neural circuitry to regulate postpartum mood and behaviour

Mammals give birth to dependent offspring and significant parental involvement is required to ensure offspring survive. During pregnancy and in the early postpartum period, hormones act on neural circuitry to bring about key changes in a mother's mood and behaviour. Read more

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