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  Adaptive immunity in multiple sclerosis: studying the antigen specificity of autoreactive B cells in MS
  Dr S J Curnow
Applications accepted all year round
Multiple sclerosis (MS) is a chronic inflammatory disease involving immune attack by autoreactive T cells and B cells. We have been studying the phenotype, frequency and antigen specificity of these adaptive immune cells in human MS.
  MRC Precision Medicine DTP: Estrogenic profiling in lung in Pulmonary Arterial Hypertension by Mass Spectrometry Imaging
  Prof R Andrew, Prof M MacLean
Application Deadline: 8 April 2019
Background. Pulmonary Arterial Hypertension (PAH) is a progressive and deadly disease leading to right heart failure, lacking effective treatment.
  Development of analytical methods for analysis of antibody-drug conjugates (ADCs) from lysates
  Prof P Barran, Prof S Flitsch
Applications accepted all year round
Background – Native MS provides an approach for intact protein analysis1 with relevance to drug discovery2 and increasingly used to analyse mAbs as well…
  A proteomic study of serum from children with neurofibromatosis type 1 autism
  Prof J Green, Dr S Garg, Dr R Unwin
Applications accepted all year round
Proteomic approaches using mass spectrometric analysis have proved a valuable tool in understanding the molecular pathogenesis of complex disorders such as schizophrenia and ASD.
  The effects of High Intensity Interval Training for People with Multiple Sclerosis
  Dr E Coulter, Prof L Paul
Application Deadline: 14 April 2019
Background. High Intensity Interval Training (HIIT) is a format of exercise of short bursts at high intensities interspersed with similar intervals of low intensity.
  Understanding transcription mediated methylation of intragenic CpG islands in health and disease
  Dr C Tufarelli, Prof S Cowley
Application Deadline: 5 May 2019
1. Project outline describing the scientific rationale of the project (max 4,000 characters incl. spaces and returns). DNA methylation is an epigenetic modification that affects gene expression without altering gene sequences.
  Quantifying response to emotional stimuli of chemical emissions on human breath
  Dr T J Dillon, Dr M S Shaw
Applications accepted all year round
Human breath is a complex source of chemical emissions into air. Recent reports suggest these emissions vary in response to audiovisual stimuli (Fig.
  Nanoporous Materials for Sensors and Catalytic Applications
  Dr V L Zholobenko
Application Deadline: 1 May 2019
The aim of this project is to develop nanostructured materials based on zeolites and MOFs as. catalysts and sensors for environmental applications.
  Developing the hydrogen-deuterium exchange mass spectrometry technology to interrogate membrane protein dynamics
  Research Group: Inorganic Chemistry
  Dr A Politis
Application Deadline: 5 April 2019
This is collaborative project between King’s Chemistry (Politis Lab) and OMass Therapeutics (Oxford). The primary aim of the project is to explore how lipids impact on the structure, dynamics and function of human integral membrane protein assemblies.
  Application of advanced analytical methods to study key aspects of health and disease
  Prof D Naughton
Applications accepted all year round
Considerable advances in the analytical capabilities of modern techniques afford a new horizon in the study of health and disease.
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