Multiple sclerosis (MS) is a chronic inflammatory disease involving immune attack by autoreactive T cells and B cells. We have been studying the phenotype, frequency and antigen specificity of these adaptive immune cells in human MS.
1. Project outline describing the scientific rationale of the project (max 4,000 characters incl. spaces and returns). DNA methylation is an epigenetic modification that affects gene expression without altering gene sequences.
This is collaborative project between King’s Chemistry (Politis Lab) and OMass Therapeutics (Oxford). The primary aim of the project is to explore how lipids impact on the structure, dynamics and function of human integral membrane protein assemblies.