In the UK alone, neurodegenerative diseases will affect 2 million people by 2051, have very limited effective treatments and cost the economy £26.3Bn annually. Read more
One of the key processes in embryo development is somitogenesis. This is the formation of segments, known as somites, that go on to develop into bone and skeletal muscle. Read more
The Notch signalling pathway is one of the key pathways required for the developing embryo. It is especially important for the process of somitogenesis, the formation of body segments that develop into e.g. Read more
Notch is one of the major highly conserved signalling pathways that regulate cell-cell communication which involves gene regulation mechanisms that control multiple processes during development and adult life. Read more
Plants living on land face brutal threats from pests, dehydration and temperature. To survive and thrive, land plants evolved a waxy ‘cuticle’ and distinctive epidermal cells such as gas pores and defensive barbs. Read more
From the earliest farmers to modern plant breeders, humans have continually modified the body plan of cereals, sometimes drastically, to generate higher grain yields. Read more
Cereal grain provides more calories than any other source to our diet, making grain production vital to food security. We study grain development in barley, a globally important cereal, and a powerful genetic model system. Read more
Plant architecture, or body plan, plays a key role in determining grain yield of crop plants. However, we have little understanding of the molecular genetic basis of architecture in the temperate cereals such as barley (Hordeum vulgare L.), especially in comparison to the warm weather crops such as rice (Oryza sativa). Read more
The immune system plays important roles in both the response to infection and in tissue repair and homeostasis. It is a complex system made up of multiple specialised cell types, each of which must communicate with each other to coordinate an effective response. Read more
T cells play critical roles in the host response to viral infection. Activated cytotoxic CD8 T cells are able to kill virally infected cells while… Read more
We investigate the how the key cell behaviours that mediate gastrulation in the early chick embryo. The chick embryo is a model for amniote development including humans. Read more
Notch is one of the major highly conserved signalling pathways that regulate cell-cell communication which involves gene regulation mechanisms that control multiple processes during development and adult life, including cell fate specification within progenitors. Read more
One of the unanticipated outcomes of population based genome sequencing has been the finding that genes involved in the regulation of many genes are mutated at high frequency in tissue specific cancers. Read more
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