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mutagenesis PhD Projects, Programmes & Scholarships
We have 27 mutagenesis PhD Projects, Programmes & Scholarships
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Mutagenesis and DNA repair in persistent cells
Antimicrobial resistance is a global health problem and we need new approaches to mitigate it. When the microbial community is treated with a lethal concentration of the antibiotic, the surviving cells are either genetically resistant or antibiotic tolerant. Read more
Self-funded PhD Project: Plastics degradation by novel Lipase
Plastics in the environment are a pressing matter. There is a need for methods to hasten the degradation of persistent plastics, even bioplastics. Read more
Functional food ingredients from the oleaginous yeast Metschnikowia pulcherrima
The department of Chemical Engineering at the University of Bath is inviting applications for the following fully funded PhD project, expected to commence January 2023. Read more
Drug discovery for P2X receptors: molecular basis of ligand-receptor interaction (FOUNTAINS_U23SF)
EP2X receptors are a family of ligand-gated ion channels activated by the neurotransmitter extracellular ATP (Illes et al., 2021). Read more
Structure and function of Batten disease proteins
The neuronal ceroid lipofucscinoses are a group of inherited neurodegenerative disorders with primarily childhood onset. The most common form, also known as Batten disease or CLN3 disease, is caused by recessively inherited mutation in the CLN3 gene. Read more
Investigating the molecular mechanisms underlying the cellular decision to initiate inflammation.
The ability of the innate immune system to discriminate between stimuli that pose little danger and those that threaten the host is a key determinant of human health. Read more
Macrophage-bacteria interactions in Cystic Fibrosis: The Cellular microbiology of the novel opportunistic bacterium achromobacter species
Chronic infection and persistent inflammation in people with cystic fibrosis (PWCF) lead to progressive lung damage. Read more
Allosteric targeting of the prostaglandin receptor EP2 to promote neuroprotection against excitoxicity
Research Group:
Wellcome-Wolfson Institute for Experimental Medicine
Excitotoxicity occurs upon brain injury or neurodegenerative diseases and exacerbates associated neuronal damages. The prostaglandin E2 receptor (EP2) has neuroprotective properties against excitotoxicity and novel molecules increasing EP2 activity have been recently discovered. Read more
Leveraging localised mutations to expand the host range of phage cocktails against Pseudomonas aeruginosa
Bacteriophages are enigmatic biological entities that have co-existed with bacteria for millions of years. The therapeutic potential of phages is enormous but is often limited by their very high host specificity. Read more
Allosteric targeting of the prostaglandin receptor EP2 to promote neuroprotection against excitoxicity
Excitotoxicity occurs upon brain injury or neurodegenerative diseases and exacerbates associated neuronal damages. The prostaglandin E2 receptor (EP2) has neuroprotective properties against excitotoxicity and novel molecules increasing EP2 activity have been recently discovered. Read more
MSc by Research: Mechanisms underlying aphid effector virulence activity
Pests and diseases are a major threat to food security with losses ranging between 20-40%. Aphids are one of the most devastating insect pests, globally. Read more
Last chance to apply
PhD position in genome stability and Cancer –Sept 2022
All organisms can suffer DNA double-strand breaks (DSBs), during meiosis, during DNA replication as elongating forks stall or collapse, or as a consequence of treatment with DNA damaging agents such as ionizing radiation. Read more
Studies of complex biomolecular systems using advanced biochemical and biophysical techniques
The project, led by. Associate Professors Mehdi Mobli. and. Jeffrey Harmer. , aims to develop new tools to reveal the structure and dynamics of complex protein systems within their native environment by combining innovative biochemistry, new magnetic resonance spectroscopy and high performance computing. Read more
4-year PhD Studentship: Nanoparticle Gene Therapy for Autosomal Dominant Polycystic Kidney Disease
Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent Mendelian inherited kidney disease (prevalence 1/1000). Read more
Investigating the Roles for deSUMOylation Enzyme SENP3 in Autophagy Impaired by α-synuclein
Aggregation of α-synuclein protein in neuronal cells has been strongly implicated in the pathogenesis of neurodegenerative disorders (Synucleinopathies) including Parkinson's disease and dementia with Lewy bodies. Read more
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