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neurodegenerative PhD Projects, Programmes & Scholarships

We have 66 neurodegenerative PhD Projects, Programmes & Scholarships

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We have 66 neurodegenerative PhD Projects, Programmes & Scholarships

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MSc by Research: ADP-ribosylation in dementia and motor neuron disease

ADP-ribosylation is a fundamental posttranslational modification where ADP-ribose is linked on to target proteins by ADP-ribose transferases and removed by the ADP-ribose hydrolases. Read more

Allosteric targeting of the prostaglandin receptor EP2 to promote neuroprotection against excitoxicity

  Research Group: Wellcome-Wolfson Institute for Experimental Medicine
Excitotoxicity occurs upon brain injury or neurodegenerative diseases and exacerbates associated neuronal damages. The prostaglandin E2 receptor (EP2) has neuroprotective properties against excitotoxicity and novel molecules increasing EP2 activity have been recently discovered. Read more

Understanding the heterogeneity of pathology in dementia with Lewy bodies to aid the interpretation of biomarkers

The primary pathology of dementia with Lewy bodies (DLB) is alpha-synuclein, however multiple studies have demonstrated that Alzheimer’s disease (AD) related pathologies (tau and beta amyloid) play an important role in disease progression driving spread of pathology and accelerating cognitive decline. Read more

Self-Navigating Nanocarriers for Intracellular Protein Delivery

Protein-based therapeutics have shown remarkable success in modulating extracellular targets; however, effective intracellular delivery remains a key challenge in biotherapeutics. Read more

Peptide-based nanoparticles for brain targeted gene delivery

Gene therapy has the potential to provide therapeutic benefit to millions of people with neurodegenerative diseases and cancer. Delivery into the brain is hampered by the blood-brain barrier (BBB), which limits the efficacy of both conventional and novel therapies at the target site. Read more

Investigating the oligogenic model of Amyotrophic Lateral Sclerosis (ALS; motor neuron disease, MND)

  Research Group: Neuroscience
Applications are invited for a multidisciplinary PhD studentship funded by the Motor Neurone Disease Association to study the cumulative contribution of coinherited subthreshold amyotrophic lateral sclerosis (ALS) risk gene variants in the development of cellular hallmarks of ALS pathology. Read more

Role of the endosomal pathway in regulating sleep and circadian rhythms

Ageing and many neurodegenerative disorders are characterized by a progressive loss of neurons in particular brain regions leading to behavioural changes including cognitive decline, sleep disruption and circadian dysregulation. Read more
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PhD Studentship in Motor Neuron Disease – Using a Primate Model to Test Novel Therapies

Overview. Interested in neurodegenerative disorders? This PhD project will use a new primate model of motor neuron disease (MND) to explore disease mechanisms and test novel therapies and biomarkers of disease progression. Read more

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