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neuromuscular PhD Projects, Programs & Scholarships

We have 14 neuromuscular PhD Projects, Programs & Scholarships

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  An exciting opportunity to examine lower limb neuromuscular control in patients with diabetes and to develop prehabilitation strategies to improve function and quality of life in this population
  Dr A Mitchell, Dr L Charalambous
Application Deadline: 24 January 2019
Ref. ISPAR-LLN1. Department. Institute of Sport and Physical Activity Research (ISPAR). Please note. Actual location of study will be at the Bedford Campus.
  The role of neuromuscular junction (NMJ) degeneration in age-related loss of skeletal muscle mass and function
  Prof MJ Jackson, Prof A McArdle, Dr A Vasilaki
Applications accepted all year round
The NMJ (or motor endplate) is a highly specialised chemical synapse that transmits action potentials from motor neurons to muscle fibres.
  Linking neural development and the DNA damage response
  Dr R Tuxworth, Prof C P Kyriacou
Application Deadline: 6 January 2019
The growth of neurons and synapses during the development is closely regulated to match pre-synaptic inputs with the requirements of post-synaptic cells.
  Developing the next generation of therapies for the childhood motor neuron disease, spinal muscular atrophy (SMA)
  Research Group: The Euan MacDonald Centre for Motor Neurone disease
  Prof T Gillingwater, Prof S Parson
Application Deadline: 7 January 2019
Spinal muscular atrophy (SMA) is a motor neuron disease caused by mutations in the SMN1 gene. Excitingly, SMA has recently moved into a therapeutic era, with an approved SMN genetargeted therapy (nusinersen/Spinraza™) that improves many aspects of disease, including motor function and survival.
  Developing the next generation of therapies for the childhood motor neuron disease, spinal muscular atrophy (SMA)
  Prof T Gillingwater, Prof S Parson
Application Deadline: 7 January 2019
Spinal muscular atrophy (SMA) is a motor neuron disease caused by mutations in the SMN1 gene. Excitingly, SMA has recently moved into a therapeutic era, with an approved SMN gene-targeted therapy (nusinersen/Spinraza™) that improves many aspects of disease, including motor function and survival.
  MRC Precision Medicine DTP: Investigating modifier transcripts in mouse models of motor neuron disease
  Dr L Murray, Dr E Hudlund
Application Deadline: 7 January 2019
The term “motor neuron disease” encompasses a spectrum of disorders in which motor neurons are the primary pathological target.
  Force platform assessment of vertical jumping: application to monitoring professional team sport athletes
  Dr P Comfort, Dr J McMahon, Dr P Jones
Applications accepted all year round
Vertical jumping (namely squat, countermovement, and drop vertical jumping) is widely used as a method for monitoring athletes’ neuromuscular function in a range of professional team sports.
  The mechanism, function, and medically-relevant dysfunction of mitochondrial complex I (NADH:ubiquinone oxidoreductase) (On the University’s application portal, please select "PhD in Medical Science at the MRC Mitochondrial Biology Unit").
  Prof J Hirst
Application Deadline: 30 June 2019
Complex I (NADH:ubiquinone oxidoreductase) catalyses the first step in the respiratory chain and oxidative phosphorylation. NADH oxidation and quinone reduction, coupled to proton translocation across the inner membrane.
  Development of gene therapies for muscular dystrophies
  Dr L Popplewell
Applications accepted all year round
The activities in the Popplewell lab focus on the development of pre-clinical gene therapies for neuromuscular diseases, in particular muscular dystrophies based on gene replacement, endonuclease-mediated gene editing, antisense oligonucleotide (AO)-induced exon skipping and gene sliencing.
  Therapeutic models for Spinal muscular atrophy
  Prof R Yáñez-Muñoz
Applications accepted all year round
Our laboratory works on Gene Therapy in the Central Nervous System and Gene Repair, using novel viral vectors, gene targeting and induced pluripotent stem cells (iPSCs) as core technologies.
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