This is an exciting project investigating neuronal circuits regulating feeding behaviour. Obesity has reached pandemic dimensions since the last several decades and is one of the leading agents behind the increased prevalence of Type 2 Diabetes and cardiovascular disease. Read more
How does the human brain work? As you read this text, the pixels on your screen are converted into a series of spike trains passing along the neural pathways in your brain, allowing you to understand the content. Read more
The importance of circadian rhythms in our physiology and behaviour, such as our sleep-wake cycle, feeding schedule, hormone production, etc, to maintain health and wellbeing is well established. Read more
Axons are the slender, often meter-long processes of neurons which electrically wire the brain. These delicate structures are up to a meter long and need to be maintained for decades. Read more
The Endoplasmic Reticulum (ER) is a multifunctional organelle, shaped as a contiguous network of membranous pipes extending throughout the cell periphery. Read more
Project Overview. Fractional order calculus (integro-differential equations that are of non-integral order) is an emerging methodology with wide applications across all areas of Physics and Engineering. Read more
Background. Chronic, low grade, inflammation plays a critical role in inflammatory and degenerative central nervous system (CNS) disorders characterised by an irreversible decline of cognitive functions. Read more
Palmitoylation (S-acylation), the only known reversible lipid modification of proteins, is an important regulator of protein localisation and function. Read more
ELAV/Hu proteins comprise a family of highly conserved neuronal RNA binding proteins important for the development of the nervous system and for neuronal functions. Read more
Neuronal injury or disease in humans often leads to disability and mortality. Neurons in humans regenerate poorly, and there are very few methods to encourage this regeneration. Read more
In the adult brain, new neurons are continuously generated in the hippocampal dentate gyrus (DG). This neurogenesis process is highly regulated and consists of cell proliferation, neuronal differentiation, neuronal maturation and survival. Read more
About 1200 people a year are left paralysed in the UK due to a Spinal Cord Injury (or SCI). This is because injuries involving the central nervous system (CNS) have very poor capacities to regenerate, thus resulting in a permanent loss of function. Read more
The research project is based on recent functional studies that conclusively demonstrated the capacity of transcranial low-intensity ultrasound stimulation to reversibly activate or suppress neural activity with high spatial specificity in vivo. Read more
After meal consumption, the brain evaluates the value of its contents and relays this information via neuronal circuits connecting the periphery with the brain (1,2). Read more
We are seeking talented, motivated students with a passion for research in understanding the causes of neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease. Read more
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